Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Patrick G. Hoggard"'
Autor:
Elaine Daniels, E Rhiannon Meaden, Saye Khoo, Jennifer Ford, Ian Williams, Patrick G. Hoggard, David Back, Margaret A. Johnson, Zoe Cuthbertson, Poe Hsyu, David Cornforth
Publikováno v:
Antiviral Therapy. 9:77-84
One of the targets of antiretroviral therapy is within cells infected with HIV. In order to improve therapeutic efficacy, it is therefore important that the intracellular pharmacokinetics of drugs, such as nelfinavir mesylate and its active metabolit
Autor:
Andrew Owen, Patrick G. Hoggard, David Back, Becky Chandler, Jennifer Ford, Saye Khoo, Lisa Almond
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 33:551-556
Several antiretroviral compounds have been shown to be substrates for the efflux protein P-glycoprotein (P-gp) although few studies have investigated the effects of drug on expression of this protein. Here, an in vitro system has been adopted to inve
Autor:
Andrew Owen, Patrick G. Hoggard
Publikováno v:
Journal of Antimicrobial Chemotherapy. 51:493-496
Autor:
Lisa Almond, David Back, Robin Wood, Corry De Vries, Patrick G. Hoggard, Stephen Kewn, Saye Khoo, Yu Lou, Jayne Gould, Anlie Maherbe, Sean D. Sales
Publikováno v:
AIDS. 16:2439-2446
Background: Nucleoside analogues are activated to their triphosphates, which compete with endogenous deoxynucleoside triphosphate (dNTP) pools to inhibit HIV reverse transcriptase. Hydroxyurea has been administered with nucleoside analogues to modula
Autor:
Nicholas J. Beeching, E Rhiannon Meaden, Ian Williams, Saye Khoo, David Back, J Lloyd, Edmund Wilkins, Patrick G. Hoggard, Kevin E. Jones, Barry Peters, Philippa Newton, Alan D. Smith, P B Carey, John Tjia
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3228-3235
Intracellular accumulation of the protease inhibitors (PIs) saquinavir (SQV), ritonavir (RTV), and indinavir (IDV) was determined in 50 human immunodeficiency virus-positive patients. Following extraction, PIs were quantified by mass spectrometry. Pa
Autor:
David Back, Saye Khoo, Philippa Newton, Ian S. Williams, E. R. Meaden, Patrick G. Hoggard, D. Aldam, John Tjia, David Cornforth, J Lloyd
Publikováno v:
Journal of Antimicrobial Chemotherapy. 50:583-588
Objectives: Efflux transporters may play a role in lowering intracellular drug concentrations. As the HIV protease inhibitors are substrates for the efflux transporters P-glycoprotein and MRP, we wished to investigate whether differences in expressio
Autor:
David Back, Helen Reynolds, Alessandro Sinicco, Giovanni Di Perri, Patrick G. Hoggard, E Rhiannon Meaden, Stefano Bonora, Marta Boffito
Publikováno v:
British Journal of Clinical Pharmacology. 54:262-268
Aims To measure the unbound plasma concentrations of saquinavir (SQV) and indinavir (IDV) and to relate them to the total plasma concentrations in order to establish the unbound percentage of protease inhibitors in vivo during a full dosage interval
Autor:
Bridget Maher, Munir Pirmohamed, Saye Khoo, John Tjia, Patrick G. Hoggard, Omar Janneh, David Back, Simon P Jones
Publikováno v:
Antiviral Therapy. 8:417-426
ObjectiveThe pathogenesis of lipodystrophy caused by the HIV protease inhibitors (PIs) and nucleoside reverse transcriptase inhibitors (NRTIs) is unclear. We have investigated the disposition of these drugs in adipocytes and the consequent effect on
Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells in vivo
Publikováno v:
Journal of Immunological Methods. 262:159-165
P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) mediate the efflux of many therapeutic agents and have been implicated in the treatment failure of many infectious diseases and cancers. The ability to characterise the expressio
Autor:
Patrick G. Hoggard, David Back
Publikováno v:
Current Opinion in Infectious Diseases. 15:3-8
Antiretroviral agents target HIV replication within infected cells. It is therefore important to focus on the pharmacology of these drugs at their site of action rather than just in plasma. Activation of nucleoside analogues to a triphosphate is esse