Zobrazeno 1 - 10
of 988
pro vyhledávání: '"Patrick G. Johnston"'
Autor:
Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt, Mark Lawler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tumour expression profiling is currently used for prognostic and predictive purposes without taking into account the intra patient heterogeneity. Here the authors show that cancer cell specific signatures overcome the tumour heterogeneity effect and
Externí odkaz:
https://doaj.org/article/4cfe33bfecaf449b9233c78e1aecfd67
Autor:
Daniel B. Longley, Kevin M. Prise, Karl T. Butterworth, Gerard G. Hanna, Timothy Harrison, Patrick G. Johnston, Caitriona Holohan, Nyree Crawford, Catherine Higgins, Joanna Majkut, Catherine Fenning, Izabela Stasik, Luke Humphreys, Conor A. Bradley, Zsuzsanna Nemeth, Kylie A. McLaughlin
Figure legends for Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e283045617eeb7207cfd83637a6fd7
https://doi.org/10.1158/1535-7163.22503607.v1
https://doi.org/10.1158/1535-7163.22503607.v1
Autor:
Patrick G. Johnston, Daniel B. Longley, Sandra Van Schaeybroeck, Philip Dunne, Suzanne Hector, Vicky M. Coyle, Gail Carson, Leanne Stevenson, Richard C. Turkington, Wendy L. Allen
PDF file - 261K, List showing 1986 genes that are uniquely altered following SN38 treatment over time in HCT116 p53null cells only. Genes have been normalised and filtered as stated in the materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e5f692e6164e59aac2080c4a376a52
https://doi.org/10.1158/1535-7163.22498386.v1
https://doi.org/10.1158/1535-7163.22498386.v1
Autor:
Daniel B. Longley, Kevin M. Prise, Karl T. Butterworth, Gerard G. Hanna, Timothy Harrison, Patrick G. Johnston, Caitriona Holohan, Nyree Crawford, Catherine Higgins, Joanna Majkut, Catherine Fenning, Izabela Stasik, Luke Humphreys, Conor A. Bradley, Zsuzsanna Nemeth, Kylie A. McLaughlin
Caspase-8 dependent apoptosis induced by IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3b846ebd2384c791188a1352be1b9e
https://doi.org/10.1158/1535-7163.22503616
https://doi.org/10.1158/1535-7163.22503616
Autor:
Sandra Van Schaeybroeck, Patrick G. Johnston, Ian G. Mills, Melissa J. Labonte, Claudio Isella, Puthen V. Jithesh, Vlad Popovici, Frank Burkamp, Wendy L. Allen, Heba Emam, Jessica-Anne Weir, Hajrah Khawaja, Arman Javadi, Alaa Refaat, Nicholas Forsythe
BRAFV600E mutations occur in ∼10% of colorectal cancer cases, are associated with poor survival, and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the biology of poor prognostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d6408b8cab0676bbd02a08487f75275
https://doi.org/10.1158/1535-7163.c.6538074.v1
https://doi.org/10.1158/1535-7163.c.6538074.v1
Autor:
Sandra Van Schaeybroeck, Patrick G. Johnston, Ian G. Mills, Melissa J. Labonte, Claudio Isella, Puthen V. Jithesh, Vlad Popovici, Frank Burkamp, Wendy L. Allen, Heba Emam, Jessica-Anne Weir, Hajrah Khawaja, Arman Javadi, Alaa Refaat, Nicholas Forsythe
Table S1: Top 20 pathways identified by IPA containing genes significantly upregulated between poor and good prognostic BRAFMT stage II/III CRC in GSE39582; Table S2: Top 20 pathways identified by IPA containing genes significantly downregulated betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b887ea2b5d55c1a80d85664426d65089
https://doi.org/10.1158/1535-7163.22505463
https://doi.org/10.1158/1535-7163.22505463
Autor:
Patrick G. Johnston, Daniel B. Longley, Sandra Van Schaeybroeck, Philip Dunne, Suzanne Hector, Vicky M. Coyle, Gail Carson, Leanne Stevenson, Richard C. Turkington, Wendy L. Allen
PDF file - 321K, List showing 2544 genes that are uniquely altered following SN38 treatment over time in HCT116 p53wild-type cells only. Genes have been normalised and filtered as stated in the materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9d0b68b7e9ec6cccc8e0ae2561b94c
https://doi.org/10.1158/1535-7163.22498389.v1
https://doi.org/10.1158/1535-7163.22498389.v1
Autor:
Patrick G. Johnston, Mark Lawler, Daniel B. Longley, Manuel Salto-Tellez, Simon McDade, Sandra Van Schaeybroeck, Maurice Loughrey, Wendy L. Allen, Helen G. Coleman, Paul G. O'Reilly, Darragh G. McArt, Philip D. Dunne
Supplementary figure 1: A +B. Hierarchical clustering of microdissected stromal and epithelial (A) and FACS sorted endothelial, fibroblast, epithelial and leukocyte (B) cell populations using previously published non-epithelial derived gene list conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a4cb37c81ec07b49d2bcc45e7bbdd5
https://doi.org/10.1158/2326-6066.22537445
https://doi.org/10.1158/2326-6066.22537445
Autor:
Sandra Van Schaeybroeck, Patrick G. Johnston, Ian G. Mills, Melissa J. Labonte, Claudio Isella, Puthen V. Jithesh, Vlad Popovici, Frank Burkamp, Wendy L. Allen, Heba Emam, Jessica-Anne Weir, Hajrah Khawaja, Arman Javadi, Alaa Refaat, Nicholas Forsythe
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31719381cc8c9646ee4cd28f7f8621c1
https://doi.org/10.1158/1535-7163.22505460
https://doi.org/10.1158/1535-7163.22505460
Autor:
Patrick G. Johnston, Daniel B. Longley, Sandra Van Schaeybroeck, Heinz-Josef D. Lenz, Michael A. Gordon, Gail Carson, Irina Proutski, Puthen V. Jithesh, Vicky M. Coyle, Leanne Stevenson, Wendy L. Allen
PDF file - 41K, QPCR validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e0dd115116b41036ab74f6f02e68d7
https://doi.org/10.1158/1535-7163.22498041.v1
https://doi.org/10.1158/1535-7163.22498041.v1