Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Patrick G Sullivan"'
Autor:
Wang-Xia Wang, Paresh Prajapati, Hemendra J Vekaria, Malinda Spry, Amber L Cloud, Patrick G Sullivan, Joe E Springer
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 3, Pp 514-522 (2021)
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular function. We previously reported that the activities of several mitochondria-enriched miRNAs regulating
Externí odkaz:
https://doaj.org/article/2942397e0bfa455292d0163fc9a85030
Autor:
Bruce A Berkowitz, Hailey K Olds, Collin Richards, Joydip Joy, Tilman Rosales, Robert H Podolsky, Karen Lins Childers, W Brad Hubbard, Patrick G Sullivan, Shasha Gao, Yichao Li, Haohua Qian, Robin Roberts
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0226840 (2020)
PurposeTo test the hypothesis that imaging biomarkers are useful for evaluating in vivo rod photoreceptor cell responses to a mitochondrial protonophore.MethodsIntraperitoneal injections of either the mitochondrial uncoupler 2,4 dinitrophenol (DNP) o
Externí odkaz:
https://doaj.org/article/d2e55ae9cde34035a82fb7d7686e1036
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 8, Pp 1338-1341 (2018)
The mitochondrion serves many functions in the central nervous system (CNS) and other organs beyond the well-recognized role of adenosine triphosphate (ATP) production. This includes calcium-dependent cell signaling, regulation of gene expression, sy
Externí odkaz:
https://doaj.org/article/2b48ecc758b245ff8fb60eeaa95d950e
Autor:
Sophiya L. Sims, Hilaree N. Frazier, Sami L. Case, Ruei-Lung Lin, James N. Trosper, Hemendra J. Vekaria, Patrick G. Sullivan, Olivier Thibault
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-13 (2024)
Abstract Energy flow within cellular elements of the brain is a well-orchestrated, tightly regulated process, however, details underlying these functions at the single-cell level are still poorly understood. Studying hypometabolism in aging and neuro
Externí odkaz:
https://doaj.org/article/59b63f3586d34508b0cc9f1d68c03cf7
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 11, Pp 1807-1808 (2017)
Externí odkaz:
https://doaj.org/article/64253b593b3e4f6db1438676750b5502
Autor:
Do Young Kim, Mohammed G Abdelwahab, Soo Han Lee, Derek O'Neill, Roger J Thompson, Henry J Duff, Patrick G Sullivan, Jong M Rho
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0119316 (2015)
Dietary and metabolic therapies are increasingly being considered for a variety of neurological disorders, based in part on growing evidence for the neuroprotective properties of the ketogenic diet (KD) and ketones. Earlier, we demonstrated that keto
Externí odkaz:
https://doaj.org/article/e11d710864e14fafa3d4d1273425670a
Autor:
Hemendra J. Vekaria, Olivia J. Kalimon, Paresh Prajapati, Gopal V. Velmurugan, Patrick G. Sullivan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Mitochondrial function analysis is a well-established method used in preclinical and clinical investigations to assess pathophysiological changes in various disease states, including traumatic brain injury (TBI). Although there are multiple approache
Externí odkaz:
https://doaj.org/article/37f7e14b817c4d12a5b5b40145968e8b
Autor:
Ravi S Akundi, Zhenyu Huang, Joshua Eason, Jignesh D Pandya, Lianteng Zhi, Wayne A Cass, Patrick G Sullivan, Hansruedi Büeler
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16038 (2011)
PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related dopam
Externí odkaz:
https://doaj.org/article/32effe2afdeb4ba387466e8ffa6afed5
Autor:
Dong-Young Choi, Mei Liu, Randy L Hunter, Wayne A Cass, Jignesh D Pandya, Patrick G Sullivan, Eun-Joo Shin, Hyoung-Chun Kim, Don M Gash, Guoying Bing
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5482 (2009)
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disorder with unknown cause, but it has been suggested that neuroinflammation may play a role in pathogenesis of the disease. Neuroinflammatory component in process of PD neurodegen
Externí odkaz:
https://doaj.org/article/249c1cd6a1f9436c85cc69b105218bfe
Autor:
Olivia J. Kalimon, Hemendra J. Vekaria, Gopal V. Velmurugan, W. Brad Hubbard, Patrick G. Sullivan
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 627-642 (2023)
Traumatic brain injury (TBI) is caused by an impact or penetrating injury to the head resulting in abnormal brain function. Mitochondrial dysfunction is an important hallmark of TBI and has been thoroughly studied in male rodent models of brain injur
Externí odkaz:
https://doaj.org/article/546dfda817774a33880b1afc465a2a50