Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Patrick G Steel"'
Autor:
Nailma S A Dos Santos, Carlos F Estevez-Castro, Juan P Macedo, Daniela F Chame, Thiago Castro-Gomes, Mariana Santos-Cardoso, Gabriela A Burle-Caldas, Courtney N Covington, Patrick G Steel, Terry K Smith, Paul W Denny, Santuza M R Teixeira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 9, p e0011646 (2023)
Sphingolipids (SLs) are essential components of all eukaryotic cellular membranes. In fungi, plants and many protozoa, the primary SL is inositol-phosphorylceramide (IPC). Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD), a c
Externí odkaz:
https://doaj.org/article/59bb370ad8bb491b8ca365e30536662c
Autor:
Douglas O Escrivani, Rebecca L Charlton, Marjolly B Caruso, Gabriela A Burle-Caldas, Maria Paula G Borsodi, Russolina B Zingali, Natalia Arruda-Costa, Marcos V Palmeira-Mello, Jéssica B de Jesus, Alessandra M T Souza, Bárbara Abrahim-Vieira, Stefanie Freitag-Pohl, Ehmke Pohl, Paul W Denny, Bartira Rossi-Bergmann, Patrick G Steel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009951 (2021)
With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets. Inspired by activity of the natural chalcone 2',6'-dihydroxy-4'-met
Externí odkaz:
https://doaj.org/article/97dcebeea4914662b9ca60f477d72118
Autor:
Elizabeth C Pinneh, Rhea Stoppel, Heather Knight, Marc R Knight, Patrick G Steel, Paul W Denny
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217087 (2019)
This research was undertaken to investigate the global role of the plant inositol phosphorylceramide synthase (IPCS), a non-mammalian enzyme previously shown to be associated with the pathogen response. RNA-Seq analyses demonstrated that over-express
Externí odkaz:
https://doaj.org/article/6b3e9de53b0a41299e3fceab9a234dee
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of act
Externí odkaz:
https://doaj.org/article/29d3af68c270402ebd30e752d82407ba
Publikováno v:
European Journal of Organic Chemistry, 2022, Vol.2022(47) [Peer Reviewed Journal]
The iridium catalysed C−H borylation of polyfluorinated arenes and heteroarenes occurs rapidly and efficiently. As with other borylation reactions, whilst steric parameters dominate, an underlying electronic influence on reaction selectivity can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afb28e69ca3319cdc893c7f97414d14
https://doi.org/10.1002/ejoc.202201005
https://doi.org/10.1002/ejoc.202201005
Autor:
Amy V. Hall, Isobel E. F. Gostick, Dmitry S. Yufit, Gloria Y. Marchant, Preyanthiny Kirubakaran, Shadrack J. Madu, Mingzhong Li, Patrick G. Steel, Jonathan W. Steed
Publikováno v:
Crystal growth & design, 2022, Vol.22(10), pp.6262-6266 [Peer Reviewed Journal]
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Open access article open access article Miltefosine is a repurposed anticancer drug and currently the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307284f421656e488ff2d82a703cc3e5
https://hdl.handle.net/2086/22214
https://hdl.handle.net/2086/22214
Autor:
Alistair K. Brown, Ahmed K. B. Aljohani, Jason H. Gill, Patrick G. Steel, Jonathan D. Sellars
Publikováno v:
Molecules, Vol 24, Iss 4, p 811 (2019)
Discovery and development of new therapeutic options for the treatment of Mycobacterium tuberculosis (Mtb) infection are desperately needed to tackle the continuing global burden of this disease and the efficacy and cost limitations associated with c
Externí odkaz:
https://doaj.org/article/38ab9c03995546de90e93ad297aa20cd
Autor:
Melissa Brazier-Hicks, Maria Schwarz, Glynn Mitchell, Robert Edwards, Ian Cummins, David J. Wortley, Patrick G. Steel, Hannah E. Straker, David John Hughes, Rebecca Florence Mary Eno, Christopher R. Coxon, Ehmke Pohl, Jenny Moore, Nawaporn Onkokesung, Stefanie Freitag-Pohl
Publikováno v:
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2021, Vol.19(42), pp.9211-9222 [Peer Reviewed Journal]
Schwarz, M, Eno, R F M, Freitag-Pohl, S, Coxon, C R, Straker, H E, Wortley, D J, Hughes, D J, Mitchell, G, Moore, J, Cummins, I, Onkokesung, N, Brazier-Hicks, M, Edwards, R, Pohl, E & Steel, P G 2021, ' Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance ', Organic and Biomolecular Chemistry, vol. 19, no. 42, pp. 9211-9222 . https://doi.org/10.1039/d1ob01802g
Organic & Biomolecular Chemistry, 2021, Vol.19(42), pp.9211-9222 [Peer Reviewed Journal]
Schwarz, M, Eno, R F M, Freitag-Pohl, S, Coxon, C R, Straker, H E, Wortley, D J, Hughes, D J, Mitchell, G, Moore, J, Cummins, I, Onkokesung, N, Brazier-Hicks, M, Edwards, R, Pohl, E & Steel, P G 2021, ' Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance ', Organic and Biomolecular Chemistry, vol. 19, no. 42, pp. 9211-9222 . https://doi.org/10.1039/d1ob01802g
The evolution and growth of multiple-herbicide resistance (MHR) in grass weeds continues to threaten global cereal production. While various processes can contribute to resistance, earlier work has identified the phi class glutathione-S-transferase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8051da3d36f1de2ecdfeeb4677109416
https://doi.org/10.1039/d1ob01802g
https://doi.org/10.1039/d1ob01802g
Plant growth promotion by the interaction of a novel synthetic small molecule with GA‐DELLA function
Publikováno v:
Plant Direct, 2022, Vol.6(4), pp.e398 [Peer Reviewed Journal]
Plant Direct 6 (2022). doi:10.1002/pld3.398
info:cnr-pdr/source/autori:Sukiran N.A., Pollastri S., Steel P.G., Knight M.R./titolo:Plant growth promotion by the interaction of a novel synthetic small molecule with GA-DELLA function/doi:10.1002%2Fpld3.398/rivista:Plant Direct/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Plant Direct 6 (2022). doi:10.1002/pld3.398
info:cnr-pdr/source/autori:Sukiran N.A., Pollastri S., Steel P.G., Knight M.R./titolo:Plant growth promotion by the interaction of a novel synthetic small molecule with GA-DELLA function/doi:10.1002%2Fpld3.398/rivista:Plant Direct/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:6
Synthesized small molecules are useful as tools to investigate hormonal signaling involved in plant growth and development. They are also important as agrochemi- cals to promote beneficial properties of crops in the field. We describe here the synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28a0d98ddc8a1066bf90f1b3dd784a9
http://dro.dur.ac.uk/36358/1/36358.pdf
http://dro.dur.ac.uk/36358/1/36358.pdf