Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patrick G Dougherty"'
Autor:
Xiang Li, Mahboubeh Kheirabadi, Patrick G. Dougherty, Kimberli J. Kamer, Xiulong Shen, Nelsa L. Estrella, Suresh Peddigari, Anushree Pathak, Sara L. Blake, Emmanuelle Sizensky, Carmen del Genio, Arti B. Gaur, Mohanraj Dhanabal, Mahasweta Girgenrath, Natarajan Sethuraman, Ziqing Qian
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 273-285 (2023)
Biological therapeutic agents are highly targeted and potent but limited in their ability to reach intracellular targets. These limitations often necessitate high therapeutic doses and can be associated with less-than-optimal therapeutic activity. On
Externí odkaz:
https://doaj.org/article/c545362a9b934efa93a2eb6bb193eec3
Autor:
Amanda B. Hummon, Dehua Pei, Amritendu Koley, Jessica K Lukowski, Estelle Cormet-Boyaka, Jack Wellmerling, Patrick G Dougherty
Publikováno v:
J Med Chem
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, encoding for a chloride ion channel. Membrane expression of CFTR is negatively regulated by CFTR-associated ligand (CAL). We previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c9736ca5455a241d397e6d370d5c9b
https://doi.org/10.1021/acs.jmedchem.0c01528
https://doi.org/10.1021/acs.jmedchem.0c01528
Autor:
Manjula Karpurapu, Jessica K Lukowski, Amritendu Koley, John W. Christman, Sangwoon Chung, Patrick G Dougherty, Dehua Pei, Ziqing Qian, Amanda B. Hummon, Hao W Li, Teja Srinivas Nirujogi, Luiza Rusu
Publikováno v:
J Med Chem
Acute respiratory distress syndrome (ARDS) is an inflammatory lung disease with a high morbidity and mortality rate, for which no pharmacologic treatment is currently available. Our previous studies discovered that a pivotal step in the disease proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771fd508385612589b19f0ff97624616
https://doi.org/10.1021/acs.jmedchem.0c01236
https://doi.org/10.1021/acs.jmedchem.0c01236
Autor:
Ashweta Sahni, George Appiah Kubi, Ziqing Qian, Jian-Guo Ren, Amritendu Koley, Patrick G Dougherty, Jin Wen, Ruchira Basu, Xiaoyan Pan, Dehua Pei, Heba Salim
Publikováno v:
J Med Chem
Stapled peptides recapitulate the binding affinity and specificity of α-helices in proteins, resist proteolytic degradation, and may provide a novel modality against challenging drug targets such as protein-protein interactions. However, most of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8209ea802cefe2b26a8c964426c9034b
https://doi.org/10.1021/acs.jmedchem.9b00456
https://doi.org/10.1021/acs.jmedchem.9b00456
Autor:
Jahan K Cooper, Qi-En Wang, Dehua Pei, Ziqing Qian, Steffen Lindert, Curran A. Rhodes, Patrick G Dougherty
Publikováno v:
Journal of the American Chemical Society. 140:12102-12110
Macrocyclic peptides are capable of binding to flat protein surfaces such as the interfaces of protein–protein interactions with antibody-like affinity and specificity, but generally lack cell permeability in order to access intracellular targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e681d7c514c58ac9f52dd7d4939197
https://doi.org/10.1021/jacs.8b06738
https://doi.org/10.1021/jacs.8b06738
Publikováno v:
Current Opinion in Chemical Biology. 38:80-86
Intracellular protein-protein interactions (PPIs) are challenging targets for conventional drug modalities, because small molecules generally do not bind to their large, flat binding sites with high affinity, whereas monoclonal antibodies cannot cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e3ae6d0d6a1da55055b381926ce8f0
https://doi.org/10.1016/j.cbpa.2017.03.011
https://doi.org/10.1016/j.cbpa.2017.03.011
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781493995035
Methods in Molecular Biology ISBN: 9781493995035
Peptides provide an attractive modality for targeting challenging drug targets such as intracellular protein-protein interactions. Unfortunately, peptides are generally impermeable to the cell membrane and inherently susceptible to proteolytic degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910f97ad28d2b2af4501653034f8e57e
https://pubmed.ncbi.nlm.nih.gov/31134566
https://pubmed.ncbi.nlm.nih.gov/31134566
Publikováno v:
Chem Rev
Approximately 75% of all disease relevant human proteins including those involved in intracellular protein-protein interactions (PPIs) are undruggable with the current drug modalities (i.e., small molecules and biologics). Macrocyclic peptides provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9e9fbc8da6358aa254c2ddd47557e9
https://pubmed.ncbi.nlm.nih.gov/31083977
https://pubmed.ncbi.nlm.nih.gov/31083977
Publikováno v:
Practical Medicinal Chemistry with Macrocycles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e0001b32b7f8292cdd179f695731e3b
https://doi.org/10.1002/9781119092599.ch6
https://doi.org/10.1002/9781119092599.ch6
Macrocyclic compounds such as cyclic peptides have emerged as a new and exciting class of drug candidates for inhibition of intracellular protein–protein interactions, which are challenging targets for conventional drug modalities (i.e. small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899ae3718a0c61b6bb70cff12847cfdd
https://europepmc.org/articles/PMC6511976/
https://europepmc.org/articles/PMC6511976/