Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Patrick G Burrola"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The receptor tyrosine kinase Mer (gene name Mertk) acts in vascular endothelial cells (ECs) to tighten the blood-brain barrier (BBB) subsequent to viral infection, but how this is achieved is poorly understood. We find that Mer controls the
Externí odkaz:
https://doaj.org/article/0e873262978d4c22b798149bd887dc1a
Autor:
Sheng Miao, Lawrence Fourgeaud, Patrick G. Burrola, Shani Stern, Yuhan Zhang, Kaisa E. Happonen, Sammy Weiser Novak, Fred H. Gage, Greg Lemke
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
The receptor tyrosine kinase Tyro3 is abundantly expressed in neurons of the neocortex, hippocampus, and striatum, but its role in these cells is unknown. We found that neuronal expression of this receptor was markedly up-regulated in the postnatal m
Externí odkaz:
https://doaj.org/article/9dfa132aca1f49d292b45beb70f65c78
The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages
Autor:
Lidia Jiménez-García, Christopher Mayer, Patrick G. Burrola, Youtong Huang, Maxim N. Shokhirev, Greg Lemke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Many apoptotic thymocytes are generated during the course of T cell selection in the thymus, yet the machinery through which these dead cells are recognized and phagocytically cleared is incompletely understood. We found that the TAM receptor tyrosin
Externí odkaz:
https://doaj.org/article/8260602afa754d16a92b4621e051de6a
Autor:
Erin D Lew, Jennifer Oh, Patrick G Burrola, Irit Lax, Anna Zagórska, Paqui G Través, Joseph Schlessinger, Greg Lemke
Publikováno v:
eLife, Vol 3 (2014)
The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineat
Externí odkaz:
https://doaj.org/article/5fea7649da76453ba6611429febbdc74
Autor:
Youtong, Huang, Kaisa E, Happonen, Patrick G, Burrola, Carolyn, O'Connor, Nasun, Hah, Ling, Huang, Axel, Nimmerjahn, Greg, Lemke
Publikováno v:
Nature immunology. 22(5)
Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer's disease and its mouse models, induced expression of Axl an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d47ebef4f7bd8be0818c80b02f863fe
https://pubmed.ncbi.nlm.nih.gov/33986528
https://pubmed.ncbi.nlm.nih.gov/33986528
Publikováno v:
Developmental Neuroscience. 15:423-432
Approximately one quarter of the AIDS patients have severe HIV encephalitis with diffuse neuronal damage that may be mediated by immune factors secreted by CNS macrophages. Based on an in vitro brain microsphere model, we developed an in vivo system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e5df6c4acd3ea012a029fc0bdb38dd
https://doi.org/10.1159/000111368
https://doi.org/10.1159/000111368
Autor:
Wolfgang Brysch, Veena Bijlani, Clayton A. Wiley, David A. DiLoreto, Coca del Cerro, Harris A. Gelbard, Jochen Herms, Cristian L. Achim, Stephen R. Dlouhy, R. Asher, Aijaz Ahmed Khan, Shashi Wadhwa, Karl-Hermann Schlingensiepen, Kirk A. Dzenko, Victoria M. Pratt, Fredricka C. Martin, Leon G. Epstein, Florianne Monnet-Tschudi, Don K. Miners, Marion E. Hodes, R.M. Pandey, Patrick G. Burrola, Uwe Zurmöhle, Manuel del Cerro, Marie-Gabrielle Zurich, Paul Honegger
Publikováno v:
Developmental Neuroscience. 15:437-440
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca28e1d206a4052ac70fccafa46dce9e
https://doi.org/10.1159/000111371
https://doi.org/10.1159/000111371
Publikováno v:
Journal of neuropathology and experimental neurology. 53(6)
Retroviral infection of the central nervous system (CNS) causes chronic functional and morphological damage in a wide variety of mammals. Neuropathological studies have focused on subcortical pathology, however, the neocortex is also affected. Becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c6d5315aa9b44417da3ebb13e85fa7
https://pubmed.ncbi.nlm.nih.gov/7964898
https://pubmed.ncbi.nlm.nih.gov/7964898
Autor:
Happonen, Kaisa E.1 (AUTHOR), Burrola, Patrick G.1 (AUTHOR), Lemke, Greg1 (AUTHOR) lemke@salk.edu
Publikováno v:
Communications Biology. 9/7/2023, Vol. 6 Issue 1, p1-14. 14p.
Publikováno v:
Pain & Central Nervous System Week; 2024, p1401-1401, 1p