Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Patrick G Bray"'
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58933 (2013)
The intraerythrocytic malaria parasite is susceptible to oxidative stress and this may play a role in the mechanism of action of some antimalarial agents. Here we show that exposure of the intraerythrocytic malaria parasite to the oxidising agent hyd
Externí odkaz:
https://doaj.org/article/3b54eb8918af47a9b6cb8964ba2b79fb
Autor:
Neill J. Liptrott, Usman Arshad, Shaun H. Pennington, Paul Curley, Andrew F. Hill, Paul M. O'Neill, Saye Khoo, Andrew Owen, Lee Tatham, Weiqian David Hong, Anthony Valentijn, Henry Pertinez, Ghaith Aljayyoussi, Steve A. Ward, Helen Box, Megan Neary, Christopher David, Rajith K. R. Rajoli, Patrick G. Bray, Steven Paul Rannard, Giancarlo A. Biagini, Joanne Sharp, Marta Boffito
Publikováno v:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
British Journal of Clinical Pharmacology
medRxiv
Authorea, Inc.
British Journal of Clinical Pharmacology
medRxiv
Authorea, Inc.
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a global pandemic by the World Health Organisation and urgent treatment and prevention strategies are needed. Many clinical trials have been initiated with exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc7778a73fd15536c6c10511e20bea7
Autor:
Andrew Owen, Neill J. Liptrott, Saye Khoo, Stephen A. Ward, Paul M. O'Neill, Steve P. Rannard, Helen Box, Usman Arshad, Henry Pertinez, Joanne Sharp, Rajith K. R. Rajoli, Ghaith Aljayyoussi, David Back, Shaun H. Pennington, Paul Curley, Megan Neary, Anthony Valentijn, Christopher David, Giancarlo A. Biagini, Lee Tatham, Patrick G. Bray
There is a rapidly expanding literature on thein vitroantiviral activity of drugs that may be repurposed for therapy or chemoprophylaxis against SARS-CoV-2. However, this has not been accompanied by a comprehensive evaluation of the ability of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ce5ef3e48b8d8621cba1cb40c1e0e1
Autor:
Sanjeev Krishna, David J. Johnson, Stephen A. Ward, Alexis Nzila, Edwin Ochong, Susan Beveridge, Paul M. O'Neill, J. Enrique Salcedo-Sora, Giancarlo A. Biagini, Patrick G. Bray, Paul A. Stocks
Publikováno v:
The Journal of Biological Chemistry
Background: Antifolates have been effective antimalarial drugs. Results: Two proteins of P. falciparum facilitate membrane transport of folates but also of pABA, a precursor of folates. Conclusion: At the concentration that pABA is in the human plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7f80a01aa15752a0f1024ae1e02f51
http://europepmc.org/articles/PMC3247980
http://europepmc.org/articles/PMC3247980
Autor:
Patrick G. Bray, Simon A. Cobbold, Adele M. Lehane, Giancarlo A. Biagini, Asif Khan, Roselani I. Henry, Kiaran Kirk, Richard J.W. Allen, Susan M. Howitt, Rhys Hayward, Kevin J. Saliba
Publikováno v:
Journal of Biological Chemistry. 285:18615-18626
The intraerythrocytic malaria parasite exerts tight control over its ionic composition. In this study, a combination of fluorescent ion indicators and (36)Cl(-) flux measurements was used to investigate the transport of Cl(-) and the Cl(-)-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566f39833585ec8ea2f5012857c84dea
https://doi.org/10.1074/jbc.m110.120980
https://doi.org/10.1074/jbc.m110.120980
Autor:
Christoph Wyen, Peter Chiba, Omar Janneh, Saye Khoo, Elizabeth Jones, David Back, Patrick G. Bray
Publikováno v:
Journal of Antimicrobial Chemotherapy. 65:906-916
BACKGROUND The intracellular and plasma concentrations of HIV protease inhibitors (HPIs) vary widely in vivo. It is unclear whether there is a concentration-dependent effect of HPIs such that at increasing concentration they may either block their ow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9060b1c85441bbc4b145dbe7b8eec579
https://doi.org/10.1093/jac/dkq082
https://doi.org/10.1093/jac/dkq082
Autor:
Narelle Cairns, Jeroen Nieuwland, James A. H. Murray, Anthony J. Miller, Christine H. Foyer, Spencer C. Maughan, Renee S Jarvis, Rüdiger Hell, Florian H. Haas, M. Pasternak, Christopher S. Cobbett, Cordula Kruse, Guy Kiddle, Benson Lim, Patrick G. Bray, Thorsten Brach, Christopher L. Muller, Mathilde Orsel, Andreas J. Meyer, Enrique Salcedo-Sora
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (5), pp.2331-2336. ⟨10.1073/pnas.0913689107⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (5), pp.2331-2336. ⟨10.1073/pnas.0913689107⟩
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (5), pp.2331-2336. ⟨10.1073/pnas.0913689107⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (5), pp.2331-2336. ⟨10.1073/pnas.0913689107⟩
In Arabidopsis thaliana , biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffeae86960e1cc10ce14f82549858291
https://doi.org/10.1073/pnas.0913689107
https://doi.org/10.1073/pnas.0913689107
Publikováno v:
British Journal of Pharmacology. 159:484-493
Background and purpose: Cultured pre-adipocytes accumulate and metabolize zidovudine (ZDV), but its mode of accumulation into these cells is unclear. We investigated the mode of accumulation of [3H]-ZDV, and the impact of changes in external pH and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bde82c5047f8d042531c88f1fbd9ab
https://doi.org/10.1111/j.1476-5381.2009.00552.x
https://doi.org/10.1111/j.1476-5381.2009.00552.x
Autor:
Jill Davies, Tafadzwa Charidza, Miriam E. Kennedy, B. Kevin Park, Amy E. Mercer, Ivo Piantanida, Michael Jones, Paul M. O'Neill, Jonathan Baird, Omar Janneh, Patrick G. Bray, Richard Cosstick, Paul A. Stocks, Sarah L. Rawe, Stephen A. Ward, Louise La Pensee
Publikováno v:
Articles
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity against HL60, MDA-MB-231 and MCF-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dfc301f102ae95bee6407f88e87303
https://doi.org/10.1016/j.bmcl.2009.02.028
https://doi.org/10.1016/j.bmcl.2009.02.028
Autor:
Stephen Hindley, Paul M. O'Neill, Eghbaleh Asadollahy, Karen Rimmer, Alison E. Shone, Gemma L. Nixon, James L. Maggs, Stephen A. Ward, Richard A. Brigandi, Martin Bates, Patrick G. Bray, P. A. Winstanley, Paul A. Stocks, Jill Davies, Silvia Parapini, Livia Vivas, Domingo Gargallo, Stephanie L. Gresham, Hollie Lander, Giancarlo A. Biagini, B. Kevin Park, Donatella Taramelli, Ramesh Bambal, Federico M. Gomez-de-las-Heras, Charles B. Davis, Charlotte Hall, Neil G. Berry, Phil Roberts, Deborah Stanford
Publikováno v:
Journal of Medicinal Chemistry. 52:1828-1844
On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-aminophenol "metabolic alert" has been modified by replacement of the 4'-hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d2075934bbaca76abf6a07eb93897a
https://doi.org/10.1021/jm8012757
https://doi.org/10.1021/jm8012757