Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Patrick G, Spinazze"'
Autor:
Kumiko, Takeuchi, Todd J, Kohn, Nicholas A, Honigschmidt, Vincent P, Rocco, Patrick G, Spinazze, Daniel J, Koch, Steven T, Atkinson, Larry W, Hertel, David L, Nelson, D Bradley, Wainscott, Laura J, Ahmad, Janice, Shaw, Penny G, Threlkeld, David T, Wong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2393-2397
Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an alpha-Me group in the piperidine ring with its specific s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2415887eb761a5e60b2f6c86c07d36ec
https://doi.org/10.1016/s0960-894x(03)00392-5
https://doi.org/10.1016/s0960-894x(03)00392-5
Autor:
Gideon Koren, Thomas Walter, Muzammil M. Mansuri, Simon Chen, Jean Bauer, Ricard P. Carlson, Jacek Ostrowski, Joyce Phelan Driscoll, Kuo-Long Yu, Neil H. Shear, Manuela G. Neuman, Joachim Barth, Patrick G. Spinazze, D. A. Hartman, Peter R. Reczek, Gary Whiting, Bodo Lehmann, S. Matschiner, Samuel Randor, John E. Starrett, Laura Hammer, Yimin Xiong, Dwora Klein, Mei-Li A. Sung., Kenneth M. Tramposch, Reinhard H.H. Neubert, Gottfried Wozel, Yeung W. Lock, Thor Roalsvig, Keith B. Glaser, Dierk Steinmann, Wolfgang Wohlrab, Charles S. Harmon, Izabella M. Malkiewicz
Publikováno v:
Skin Pharmacology and Physiology. 8:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5968fd863a16cb0c9a32b79a9825577
https://doi.org/10.1159/000211358
https://doi.org/10.1159/000211358
Autor:
Kuo-Long Yu, Laura Hammer, Jacek Ostrowski, Peter R. Reczek, John E. Starrett, Gary Whiting, Muzammil M. Mansuri, Simon Chen, Patrick G. Spinazze, Thor Roalsvig, Joyce Phelan Driscoll, Kenneth M. Tramposch
Publikováno v:
Skin Pharmacology and Physiology. 8:292-299
The three retinoic acid receptors (RARΑ, RARΒ and RARΓ) are known to modulate the transcription of target genes through interaction of the individual receptors with their naturally occurring ligand, retinoic acid (RA). Since RA has multiple effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d70bbdf308353faa01b35cad7b7e55
https://doi.org/10.1159/000211360
https://doi.org/10.1159/000211360
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:535-538
A facile synthesis of a series of potential pseudosymmetric HIV-protease inhibitors containing 1,3-diamino-2-hydroxypropane moiety is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71eedeb96bf1ce43bd08af6952b7e746
https://doi.org/10.1016/s0960-894x(01)81222-1
https://doi.org/10.1016/s0960-894x(01)81222-1
Autor:
Thor Roalsvig, David R. Tortolani, Kuo-Long Yu, Jomary A. Honeyman, Laura Hammer, Patrick G. Spinazze, Peter R. Reczek, Stephen J. Currier, Muzammil M. Mansuri, John E. Starrett, Jacek Ostrowski, Edward J. Pack
Publikováno v:
ChemInform. 27
In search for retinoic acid receptor (RAR) selective ligands, a series of 6-substituted 2-naphthoic acid retinoids were synthesized and evaluated in vitro in a transactivation assay and a competition binding assay for all RARs. These derivatives, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f71896cf838c02e0988bf39b26ac888
https://doi.org/10.1002/chin.199638128
https://doi.org/10.1002/chin.199638128
Autor:
Kumiko Takeuchi, Todd J. Kohn, Nicholas A. Honigschmidt, Vincent P. Rocco, Patrick G. Spinazze, Susan K. Hemrick-Luecke, Linda K. Thompson, David C. Evans, Kurt Rasmussen, Deanna Koger, David Lodge, Laura J. Martin, Janice Shaw, Penny G. Threlkeld, David T. Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61281b6574f3b8c2cceccbc47e8fd960
https://pubmed.ncbi.nlm.nih.gov/16298130
https://pubmed.ncbi.nlm.nih.gov/16298130
Autor:
Vincent P. Rocco, Patrick G. Spinazze, Todd J. Kohn, Nicholas A. Honigschmidt, David L. Nelson, D. Bradley Wainscott, Laura J. Ahmad, Janice Shaw, Penny G. Threlkeld, David T. Wong, Kumiko Takeuchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(10)
A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f10f6b1df59c3ece005d1af7091cdaa
https://pubmed.ncbi.nlm.nih.gov/15109671
https://pubmed.ncbi.nlm.nih.gov/15109671
Autor:
Kumiko Takeuchi, Todd J Kohn, Nicholas A Honigschmidt, Vincent P Rocco, Patrick G Spinazze, Steven T Atkinson, Larry W Hertel, David L Nelson, D.Bradley Wainscott, Laura J Ahmad, Janice Shaw, Penny G Threlkeld, David T Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(22)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470085d4b8c94794f86762633f5876c1
https://pubmed.ncbi.nlm.nih.gov/14592479
https://pubmed.ncbi.nlm.nih.gov/14592479
Autor:
Thor Roalsvig, John E. Starrett, Laura Hammer, Edward J. Pack, Stephen J. Currier, Jomary A. Honeyman, Kuo-Long Yu, David R. Tortolani, Muzammil M. Mansuri, Peter R. Reczek, Patrick G. Spinazze, Jacek Ostrowski
Publikováno v:
Journal of medicinal chemistry. 39(12)
In search for retinoic acid receptor (RAR) selective ligands, a series of 6-substituted 2-naphthoic acid retinoids were synthesized and evaluated in vitro in a transactivation assay and a competition binding assay for all RARs. These derivatives, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19238ada04770f2406763afd4574976d
https://pubmed.ncbi.nlm.nih.gov/8691435
https://pubmed.ncbi.nlm.nih.gov/8691435
Autor:
Laura Hammer, Samuel Randor, Jacek Ostrowski, Joyce Phelan Driscoll, Gideon Koren, Ricard P. Carlson, Kuo-Long Yu, Thomas Walter, Charles S. Harmon, D. A. Hartman, Neil H. Shear, Dwora Klein, Yeung W. Lock, Kenneth M. Tramposch, Gary Whiting, Manuela G. Neuman, Peter R. Reczek, John E. Starrett, Reinhard H.H. Neubert, Dierk Steinmann, Jean Bauer, Keith B. Glaser, Joachim Barth, Yimin Xiong, Muzammil M. Mansuri, Simon Chen, S. Matschiner, Bodo Lehmann, Wolfgang Wohlrab, Mei-Li A. Sung., Patrick G. Spinazze, Thor Roalsvig, Gottfried Wozel, Izabella M. Malkiewicz
Publikováno v:
Skin Pharmacology and Physiology. 8:337-338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9007f06cbf0354eb01a11d29ec7b7493
https://doi.org/10.1159/000211367
https://doi.org/10.1159/000211367