Výsledky vyhledávání - "Patrick G, Hoggard"

Intracellular and Plasma Pharmacokinetics of Nelfinavir and M8 in HIV-Infected Patients: Relationship with P-Glycoprotein Expression

Autor: Elaine Daniels, E Rhiannon Meaden, Saye Khoo, Jennifer Ford, Ian Williams, Patrick G. Hoggard, David Back, Margaret A. Johnson, Zoe Cuthbertson, Poe Hsyu, David Cornforth

Publikováno v: Antiviral Therapy. 9:77-84

One of the targets of antiretroviral therapy is within cells infected with HIV. In order to improve therapeutic efficacy, it is therefore important that the intracellular pharmacokinetics of drugs, such as nelfinavir mesylate and its active metabolit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bfa5a90e30fee194745779463e67f29
https://doi.org/10.1177/135965350400900101

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The Effects of Protease Inhibitors and Nonnucleoside Reverse Transcriptase Inhibitors on P-Glycoprotein Expression in Peripheral Blood Mononuclear Cells In Vitro

Autor: Andrew Owen, Patrick G. Hoggard, David Back, Becky Chandler, Jennifer Ford, Saye Khoo, Lisa Almond

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 33:551-556

Several antiretroviral compounds have been shown to be substrates for the efflux protein P-glycoprotein (P-gp) although few studies have investigated the effects of drug on expression of this protein. Here, an in vitro system has been adopted to inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dd123cd905a3c39a6d754cd5cefb30
https://doi.org/10.1097/00126334-200308150-00001

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Time-dependent changes in HIV nucleoside analogue phosphorylation and the effect of hydroxyurea

Autor: Lisa Almond, David Back, Robin Wood, Corry De Vries, Patrick G. Hoggard, Stephen Kewn, Saye Khoo, Yu Lou, Jayne Gould, Anlie Maherbe, Sean D. Sales

Publikováno v: AIDS. 16:2439-2446

Background: Nucleoside analogues are activated to their triphosphates, which compete with endogenous deoxynucleoside triphosphate (dNTP) pools to inhibit HIV reverse transcriptase. Hydroxyurea has been administered with nucleoside analogues to modula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40e6c2042e7d0a0ec267428e3acc866
https://doi.org/10.1097/00002030-200212060-00009

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Intracellular Accumulation of Human Immunodeficiency Virus Protease Inhibitors

Autor: Nicholas J. Beeching, E Rhiannon Meaden, Ian Williams, Saye Khoo, David Back, J Lloyd, Edmund Wilkins, Patrick G. Hoggard, Kevin E. Jones, Barry Peters, Philippa Newton, Alan D. Smith, P B Carey, John Tjia

Publikováno v: Antimicrobial Agents and Chemotherapy. 46:3228-3235

Intracellular accumulation of the protease inhibitors (PIs) saquinavir (SQV), ritonavir (RTV), and indinavir (IDV) was determined in 50 human immunodeficiency virus-positive patients. Following extraction, PIs were quantified by mass spectrometry. Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0240f9dbd2bb688a08a91e9d952761
https://doi.org/10.1128/aac.46.10.3228-3235.2002

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P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals

Autor: David Back, Saye Khoo, Philippa Newton, Ian S. Williams, E. R. Meaden, Patrick G. Hoggard, D. Aldam, John Tjia, David Cornforth, J Lloyd

Publikováno v: Journal of Antimicrobial Chemotherapy. 50:583-588

Objectives: Efflux transporters may play a role in lowering intracellular drug concentrations. As the HIV protease inhibitors are substrates for the efflux transporters P-glycoprotein and MRP, we wished to investigate whether differences in expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9204008d465f9b8588be58bd021957
https://doi.org/10.1093/jac/dkf161

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The unbound percentage of saquinavir and indinavir remains constant throughout the dosing interval in HIV positive subjects

Autor: David Back, Helen Reynolds, Alessandro Sinicco, Giovanni Di Perri, Patrick G. Hoggard, E Rhiannon Meaden, Stefano Bonora, Marta Boffito

Publikováno v: British Journal of Clinical Pharmacology. 54:262-268

Aims To measure the unbound plasma concentrations of saquinavir (SQV) and indinavir (IDV) and to relate them to the total plasma concentrations in order to establish the unbound percentage of protease inhibitors in vivo during a full dosage interval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71fd536123a797959b00c18556658e0a
https://doi.org/10.1046/j.1365-2125.2002.01663.x

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Intracellular Disposition and Metabolic Effects of Zidovudine, Stavudine and Four Protease Inhibitors in Cultured Adipocytes

Autor: Bridget Maher, Munir Pirmohamed, Saye Khoo, John Tjia, Patrick G. Hoggard, Omar Janneh, David Back, Simon P Jones

Publikováno v: Antiviral Therapy. 8:417-426

ObjectiveThe pathogenesis of lipodystrophy caused by the HIV protease inhibitors (PIs) and nucleoside reverse transcriptase inhibitors (NRTIs) is unclear. We have investigated the disposition of these drugs in adipocytes and the consequent effect on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f75e3ed39e088eb9ac7886305488bad9
https://doi.org/10.1177/135965350300800509

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Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells in vivo

Autor: David Back, Patrick G. Hoggard, Saye Khoo, E. R. Meaden

Publikováno v: Journal of Immunological Methods. 262:159-165

P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) mediate the efflux of many therapeutic agents and have been implicated in the treatment failure of many infectious diseases and cancers. The ability to characterise the expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2a74dd1b6fb2e0dc314ba38c15156e
https://doi.org/10.1016/s0022-1759(02)00020-0

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Intracellular pharmacology of nucleoside analogues and protease inhibitors: role of transporter molecules

Autor: Patrick G. Hoggard, David Back

Publikováno v: Current Opinion in Infectious Diseases. 15:3-8

Antiretroviral agents target HIV replication within infected cells. It is therefore important to focus on the pharmacology of these drugs at their site of action rather than just in plasma. Activation of nucleoside analogues to a triphosphate is esse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d21b4229c522c43ee8adeef4e3d644
https://doi.org/10.1097/00001432-200202000-00002

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