Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Patrick Fitzgerald"'
Autor:
Diego A. Rodriguez, Bart Tummers, Jeremy J.P. Shaw, Giovanni Quarato, Ricardo Weinlich, James Cripps, Patrick Fitzgerald, Laura J. Janke, Stephane Pelletier, Jeremy Chase Crawford, Douglas R. Green
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114335- (2024)
Summary: Perturbation of the apoptosis and necroptosis pathways critically influences embryogenesis. Receptor-associated protein kinase-1 (RIPK1) interacts with Fas-associated via death domain (FADD)-caspase-8-cellular Flice-like inhibitory protein l
Externí odkaz:
https://doaj.org/article/1e0db83b24f847f8b7f218099ee40210
Autor:
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2007 (2023)
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged
Externí odkaz:
https://doaj.org/article/52442aebd7684326868078bfe18e45e8
Autor:
Joana S. Cruz-Pereira, Gerard M. Moloney, Thomaz F.S. Bastiaanssen, Serena Boscaini, Gabriel Tofani, Julia Borras-Bisa, Marcel van de Wouw, Patrick Fitzgerald, Timothy G. Dinan, Gerard Clarke, John F. Cryan
Publikováno v:
Neurobiology of Stress, Vol 21, Iss , Pp 100501- (2022)
Aging has a significant impact on physiology with implications for central nervous system function coincident with increased vulnerability to stress exposures. A number of stress-sensitive molecular mechanisms are hypothesized to underpin age-related
Externí odkaz:
https://doaj.org/article/89034c3e2a264e25a9b460bc76b6cafa
Autor:
Mónica Tramullas, James M. Collins, Patrick Fitzgerald, Timothy G. Dinan, Siobhain M. O’ Mahony, John F. Cryan
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102850- (2021)
Summary: Visceral hypersensitivity (VH) is a hallmark of many functional gastrointestinal disorders including irritable bowel syndrome and is categorized by a dull, diffuse sensation of abdominal pain. Recently, the gut microbiota has been implicated
Externí odkaz:
https://doaj.org/article/d3747ee7787846bc9127a4810637f927
Autor:
Qingzhi Zhu, J. Kirk Cochran, Christina Heilbrun, Hang Yin, Huan Feng, Joseph J. Tamborski, Patrick Fitzgerald, Wen Cong
Publikováno v:
Frontiers in Earth Science, Vol 9 (2021)
Loss of tidal wetlands is a world-wide phenomenon. Many factors may contribute to such loss, but among them are geochemical stressors such as exposure of the marsh plants to elevated levels on hydrogen sulfide in the pore water of the marsh peat. Her
Externí odkaz:
https://doaj.org/article/ec345626309e41b1968a10367dbc10c3
Autor:
Dinesh K. Barupal, Ying Zhang, Tong Shen, Sili Fan, Bryan S. Roberts, Patrick Fitzgerald, Benjamin Wancewicz, Luis Valdiviez, Gert Wohlgemuth, Gregory Byram, Ying Yng Choy, Bennett Haffner, Megan R. Showalter, Arpana Vaniya, Clayton S. Bloszies, Jacob S. Folz, Tobias Kind, Ann M. Flenniken, Colin McKerlie, Lauryl M. J. Nutter, Kent C. Lloyd, Oliver Fiehn
Publikováno v:
Metabolites, Vol 9, Iss 5, p 101 (2019)
Mouse knockouts facilitate the study ofgene functions. Often, multiple abnormal phenotypes are induced when a gene is inactivated. The International Mouse Phenotyping Consortium (IMPC) has generated thousands of mouse knockouts and catalogued their p
Externí odkaz:
https://doaj.org/article/82bd7caeac484fafbefa4cf0cc55a23b
Autor:
Christopher J McDermott, Mike J Bradburn, Chin Maguire, Cindy L Cooper, Wendy O Baird, Susan K Baxter, Judith Cohen, Hannah Cantrill, Simon Dixon, Roger Ackroyd, Simon Baudouin, Andrew Bentley, Richard Berrisford, Stephen Bianchi, Stephen C Bourke, Roy Darlison, John Ealing, Mark Elliott, Patrick Fitzgerald, Simon Galloway, Hisham Hamdalla, C Oliver Hanemann, Philip Hughes, Ibrahim Imam, Dayalan Karat, Roger Leek, Nick Maynard, Richard W Orrell, Abeezar Sarela, John Stradling, Kevin Talbot, Lyn Taylor, Martin Turner, Anita K Simonds, Tim Williams, Wisia Wedzicha, Carolyn Young, Pamela J Shaw
Publikováno v:
Health Technology Assessment, Vol 20, Iss 45 (2016)
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in death, usually from respiratory failure, within 2–3 years of symptom onset. Non-invasive ventilation (NIV) is a treatment that when given to patients in res
Externí odkaz:
https://doaj.org/article/69ae3de3a3a84bfcbaa9492b27d7ef41
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70401 (2013)
ObjectiveChildren with Down syndrome, the most common genetic cause of intellectual disability, are prone to multiple and varied health-related problems. This study describes patterns of hospitalisations for children and young people with Down syndro
Externí odkaz:
https://doaj.org/article/64506bdd52314136a5bf2fb002fa99b7
Autor:
Eoin Barrett, Patrick Fitzgerald, Timothy G Dinan, John F Cryan, R Paul Ross, Eamonn M Quigley, Fergus Shanahan, Barry Kiely, Gerald F Fitzgerald, Paul W O'Toole, Catherine Stanton
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48159 (2012)
The aim of this study was to compare the impact of dietary supplementation with a Bifidobacterium breve strain together with linoleic acid & α-linolenic acid, for 7 weeks, on colonic sensitivity and fatty acid metabolism in rats. Maternally separate
Externí odkaz:
https://doaj.org/article/8512c822a96c4926bc4d9aeb896fa3af
Autor:
Susan Booysen, Gillian Godsell, Rekgotsofetse Chikane, Sizwe Mpofu-Walsh, Omhle Ntshingila, Refiloe Lepere, Swankie Mofoko, Ayabonga Nase, David Everatt, Lynn Hewlett, Nomagugu Masuku-Mukadah, Horácio Lucas Zandamela, Koffi Kouakou, William Gumede, Patrick Bond, Vishwas Satgar, Patrick Fitzgerald, Oliver Seale, Pundy Pillay, Darlene Miller, Thad Metz
#FeesMustFall, the student revolt that began in October 2015, was an uprising against lack of access to, and financial exclusion from, higher education in South Africa. More broadly, it radically questioned the socio-political dispensation resulting