Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Patrick Fier"'
Autor:
Patrick Fier, Kevin Maloney, Grant Murphy, Neil Strotman, William Morris, Jessica Hurtak, Anders Knight, Jonathan Vroom, Hsing-I Ho, Weilan Pan, Deeptak Verma, Mark Huffman, Hao Yang, Tetsuji Itoh, Peter Maligres, Jongrock Kong, Steven Silverman, John McIntosh, Tamas Benkovics
Molnupiravir (MK-4482) is an investigational direct-acting antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand for this compound, it was critical to develop a sustainable and efficient synthesis fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7442e47261142bf89b4b8dfe127586a9
https://doi.org/10.26434/chemrxiv.13472373
https://doi.org/10.26434/chemrxiv.13472373
We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site- and chemoselectivity. The novel reagent was prepared on 200 gram-scale in a single step, reacts in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12832cab23fe0833f737e83c7ed37fe8
https://doi.org/10.26434/chemrxiv.12049554.v1
https://doi.org/10.26434/chemrxiv.12049554.v1
Autor:
Patrick Fier
Publikováno v:
Organic Syntheses. 94:46-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa58dff6baa8da059b32658e0b1c2a5
https://doi.org/10.15227/orgsyn.094.0046
https://doi.org/10.15227/orgsyn.094.0046
Autor:
Jonathan Hughes, Patrick Fier
Herein we describe the development of the first reductive cross-electrophile coupling between alkyl sulfones and aryl bromides. The use of alkyl sulfones as coupling partners offers strategic advantages over other alkyl electrophiles used in reductiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1d9de5f3ea46c9f605de2838fe8a98
https://doi.org/10.26434/chemrxiv.8141993
https://doi.org/10.26434/chemrxiv.8141993
Autor:
Kevin M. Maloney, Patrick Fier
Herein we describe the development and application of a method for the mild, late-stage conversion of primary sulfonamides to several other other functional groups. These reactions occur via initial reductive deamination of sulfonamides to sulfinates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d5901f8345d693f31878370146625b7
https://doi.org/10.26434/chemrxiv.7550117
https://doi.org/10.26434/chemrxiv.7550117