Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Patrick Fanelli"'
Autor:
Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
Publikováno v:
Toxicology and Applied Pharmacology
Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0f
http://europepmc.org/articles/PMC7322544
http://europepmc.org/articles/PMC7322544
Autor:
Frederick Sannajust, Jeffery J. Travis, Pierre Morissette, Christopher P. Regan, Patrick Fanelli, Kevin Fitzgerald, S. Wang, Pamela Gerenser
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:171-182
A negative electromechanical window (EMw) was recently proposed as a better preclinical tool than QTc interval to predict clinical pro-arrhythmic potential. As such, we utilized the ketamine/xylazine anesthetized guinea pig to characterize the EMw an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a055f517d381f67f504072d77e370210
https://doi.org/10.1016/j.vascn.2016.06.003
https://doi.org/10.1016/j.vascn.2016.06.003
Autor:
Sebastian Polak, Blanca Rodriguez, Elisa Passini, Patrick Fanelli, Jin Zhai, Kevin Fitzgerald, Jeffrey Travis, Pierre Morissette, Anne S. Y. Chain, Frederick Sannajust, Christopher P. Regan
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106804
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4e31eadcae91d227695d883498ef2d
https://doi.org/10.1016/j.vascn.2020.106804
https://doi.org/10.1016/j.vascn.2020.106804
Autor:
Kevin Fitzgerald, Hillary Regan, Patrick Fanelli, Jeffrey Travis, Pierre Morissette, Pamela Gerenser, Sylvain Bernasconi, Christopher P. Regan, Frederick Sannajust
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 75:52-61
The anesthetized guinea pig (ANES GP) has proven to be an effective small animal model to evaluate cardiac electrophysiologic effects of drug-candidate molecules during lead optimization. While heart rate (HR) corrected QT interval (QTc) is a key var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa07ed9bc4ab413d65a489995cdb9854
https://doi.org/10.1016/j.vascn.2015.05.007
https://doi.org/10.1016/j.vascn.2015.05.007
Autor:
Bharathi Balasubramanian, Pamela Gerenser, Frederick Sannajust, Blanca Rodriguez, Patrick Fanelli, Alfonso Bueno-Orovio, Elisa Passini, Pierre Morissette, Jeffrey Travis, Christopher P. Regan
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:144-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b1ff404975e2a3c35ba85a678e9719e
https://doi.org/10.1016/j.vascn.2018.01.479
https://doi.org/10.1016/j.vascn.2018.01.479
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f83729267dbf4723386e2dc28b7e7f
https://doi.org/10.1016/j.vascn.2019.05.052
https://doi.org/10.1016/j.vascn.2019.05.052
Autor:
Patrick Fanelli, Shaun Gruver, Robert V. Brockway, Theodore Detwiler, Gary Miller, Frederick Sannajust, Tom Delahanty, Christopher P. Regan, Hillary Regan
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b51d0914c224d42568baf14794f50905
https://doi.org/10.1016/j.vascn.2019.05.124
https://doi.org/10.1016/j.vascn.2019.05.124
Autor:
Shaun Gruver, Hillary Regan, Pierre Morissette, Patrick Fanelli, Frederick Sannajust, Theodore Detwiler, Christopher P. Regan
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff1f25a34af567cca0980fde60d9014
https://doi.org/10.1016/j.vascn.2019.05.123
https://doi.org/10.1016/j.vascn.2019.05.123
Autor:
Jin Zhai, Christopher P. Regan, Elisa Passini, Frederick Sannajust, Pierre Morissette, Patrick Fanelli, Blanca Rodriguez, Jeffrey Travis, Alfonso Bueno-Orovio, John Imredy, Spencer J. Dech
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fca4db2a3f96db80c76262b1872ad0b
https://doi.org/10.1016/j.vascn.2019.05.103
https://doi.org/10.1016/j.vascn.2019.05.103
Autor:
Christa M. Damkaoutis, Patrick Fanelli, Joel H. Greenberg, Daisuke Furuya, Steven Breslow, Peter J. Hand, John R. Hoffman, Shaun Sheehan, Rebecca L. Craik, Martin Reivich, Andrea Ketschek
Publikováno v:
Brain Research. 965:91-99
Rats use their vibrissae for a variety of exploratory tasks including location of objects and discrimination of texture. This study examines recovery in vibrissal function following a unilateral ischemic injury to the somatosensory cortex. Vibrissal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112d9b98b9a80a41b9ef65cba1212bce
https://doi.org/10.1016/s0006-8993(02)04141-0
https://doi.org/10.1016/s0006-8993(02)04141-0