Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Patrick F. McArdle"'
Autor:
Jia-Lu Qiao, Rebecca T. Levinson, Bowang Chen, Stefan T. Engelter, Philipp Erhart, Brady J. Gaynor, Patrick F. McArdle, Kristina Schlicht, Michael Krawczak, Martin Stenman, Arne G. Lindgren, John W. Cole, Caspar Grond-Ginsbach
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Objective: Most methods to detect copy number variation (CNV) have high false positive rates, especially for small CNVs and in real-life samples from clinical studies. In this study, we explored a novel scatterplot-based method to detect CNVs in micr
Externí odkaz:
https://doaj.org/article/7be1580509cb41f88911f69fde5cde78
Autor:
Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Sungmin Hong, Robert W. Regenhardt, Mikael Brudfors, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, Oscar R. Benavente, Stephen Bevan, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Martin Söderholm, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Christina Jern, Arne G. Lindgren, Jane Maguire, Danilo Bzdok, Ona Wu, MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium, Natalia S. Rost
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Acute ischemic stroke impacts men and women differently. Here, the authors show how different lesion patterns in men and women are linked to the extent of stroke severity.
Externí odkaz:
https://doaj.org/article/f7726bf0402c4666976e1614c8a746d5
Autor:
Anna K. Bonkhoff, Teresa Ullberg, Martin Bretzner, Sungmin Hong, Markus D. Schirmer, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian V. Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Christina Jern, Arne G. Lindgren, Jane Maguire, Ona Wu, Petrea Frid, Natalia S. Rost, Johan Wasselius
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Background purposeA substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort.Materials and methodsAnalyses relied upon im
Externí odkaz:
https://doaj.org/article/af8a65951b1f4d6398c01844d20de4ed
Autor:
Huichun Xu, Kevin Nguyen, Brady J. Gaynor, Hua Ling, Wei Zhao, Patrick F. McArdle, Timothy D. O’Connor, O. Colin Stine, Kathleen A. Ryan, Megan Lynch, Jennifer A. Smith, Jessica D. Faul, Yao Hu, Jeffrey W. Haessler, Myriam Fornage, Charles Kooperberg, on behalf of the Trans-Omics for Precision Medicine (TOPMed) Stroke Working Group, James A. Perry, Charles C. Hong, John W. Cole, Elizabeth Pugh, Kimberly Doheny, Sharon L. R. Kardia, David R. Weir, Steven J. Kittner, Braxton D. Mitchell
Publikováno v:
Genes, Vol 14, Iss 1, p 61 (2022)
Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare, we perform
Externí odkaz:
https://doaj.org/article/65874cd4b8db4245806a867e3399fb80
Autor:
Sungmin Hong, Anne-Katrin Giese, Markus D. Schirmer, Anna K. Bonkhoff, Martin Bretzner, Pamela Rist, Adrian V. Dalca, Robert W. Regenhardt, Mark R. Etherton, Kathleen L. Donahue, Marco Nardin, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, Oscar R. Benavente, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Jaume Roquer, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Christian Enzinger, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Ona Wu, Christina Jern, Arne G. Lindgren, Jane Maguire, Liisa Tomppo, Polina Golland, Natalia S. Rost, The MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditio
Externí odkaz:
https://doaj.org/article/ba9cea9aa419403ca81dc6c8c528dcc3
Autor:
Martin Bretzner, Anna K. Bonkhoff, Markus D. Schirmer, Sungmin Hong, Adrian V. Dalca, Kathleen L. Donahue, Anne-Katrin Giese, Mark R. Etherton, Pamela M. Rist, Marco Nardin, Razvan Marinescu, Clinton Wang, Robert W. Regenhardt, Xavier Leclerc, Renaud Lopes, Oscar R. Benavente, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Patrick F. McArdle, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ona Wu, Ramin Zand, Bradford B. Worrall, Jane M. Maguire, Arne Lindgren, Christina Jern, Polina Golland, Grégory Kuchcinski, Natalia S. Rost
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
ObjectiveNeuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic
Externí odkaz:
https://doaj.org/article/8aed34c84a7f4971a4a1b4072017c1b2
Autor:
Mattias Drake, Petrea Frid, Björn M. Hansen, Ona Wu, Anne-Katrin Giese, Markus D. Schirmer, Kathleen Donahue, Lisa Cloonan, Robert E. Irie, Mark J. R. J. Bouts, Elissa C. McIntosh, Steven J. T. Mocking, Adrian V. Dalca, Ramesh Sridharan, Huichun Xu, Eva Giralt-Steinhauer, Lukas Holmegaard, Katarina Jood, Jaume Roquer, John W. Cole, Patrick F. McArdle, Joseph P. Broderick, Jordi Jiménez-Conde, Christina Jern, Brett M. Kissela, Dawn O. Kleindorfer, Robin Lemmens, James F. Meschia, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Vincent Thijs, Daniel Woo, Bradford B. Worrall, Steven J. Kittner, Braxton D. Mitchell, Jonathan Rosand, Polina Golland, Arne Lindgren, Natalia S. Rost, Johan Wassélius
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke
Externí odkaz:
https://doaj.org/article/9bf9086498574e389988819cca8b36c3
Autor:
Christina G. Tise, Leslie E. Anforth, Albert E. Zhou, James A. Perry, Patrick F. McArdle, Elizabeth A. Streeten, Alan R. Shuldiner, Laura M. Yerges-Armstrong
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 10, Iss C, Pp 84-91 (2017)
Context: Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA). Sulfation reactions are thought to b
Externí odkaz:
https://doaj.org/article/c40e542d08524a63a4b719be6e38e592
Autor:
Markus D. Schirmer, Adrian V. Dalca, Ramesh Sridharan, Anne-Katrin Giese, Kathleen L. Donahue, Marco J. Nardin, Steven J.T. Mocking, Elissa C. McIntosh, Petrea Frid, Johan Wasselius, John W. Cole, Lukas Holmegaard, Christina Jern, Jordi Jimenez-Conde, Robin Lemmens, Arne G. Lindgren, James F. Meschia, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Vincent Thijs, Daniel Woo, Achala Vagal, Huichun Xu, Steven J. Kittner, Patrick F. McArdle, Braxton D. Mitchell, Jonathan Rosand, Bradford B. Worrall, Ona Wu, Polina Golland, Natalia S. Rost
Publikováno v:
NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)
White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS). However, current approaches to its quantification on clinic
Externí odkaz:
https://doaj.org/article/1f1b19db179a4f12b2de8cb741848607
Autor:
Braxton D Mitchell, Myriam eFornage, Patrick F. McArdle, Yu-Ching eCheng, Sara ePulit, Quenna eWong, Tushar eDave, Stephen R Williams, Roderick eCorriveau, Katrina eGwinn, Kimberly eDoheny, Cathy eLaurie, Stephen S Rich, Paul ede Bakker
Publikováno v:
Frontiers in Genetics, Vol 5 (2014)
Genome-wide association studies (GWAS) are widely applied to identify susceptibility loci for a variety of diseases using genotyping arrays that interrogate known polymorphisms throughout the genome. A particular strength of GWAS is that it is unbias
Externí odkaz:
https://doaj.org/article/b8f596e031e1470da5739e5e0f4d43d9