Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Patrick F. Kiser"'
Autor:
Christine Tagliaferri Rael, Rebecca Giguere, Sara Sutton, Elizabeth Horn, Robert J. Schieffer, George J. Greene, Richard D'Aquila, Ewa Bryndza Tfaily, Patrick F. Kiser, Thomas J. Hope
Publikováno v:
AIDS Res Hum Retroviruses
A longer acting, removable implant for HIV prevention has the potential to improve uptake of HIV pre-exposure prophylaxis (PrEP) by removing the need for daily adherence to an oral tablet, reducing potential side effects, and eliminating concerns abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529768350d45555c9fd4e29fe3a59686
https://doi.org/10.1089/aid.2022.0035
https://doi.org/10.1089/aid.2022.0035
Autor:
Robert J. Schieffer, George J. Greene, Ewa Bryndza Tfaily, Patrick F. Kiser, Thomas J. Hope, Richard T. D'Aquila, Christine Tagliaferri Rael, Alex Carballo-Diéguez, Rebecca Giguere
Publikováno v:
AIDS Res Hum Retroviruses
Long-acting delivery modalities of HIV pre-exposure prophylaxis (PrEP), such as subdermal implants, are in development. To facilitate end-user uptake and sustained use, it is critical to understand potential consumers' and physician prescribers' pref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cdbc0c218e248d91d09d0a48675122
https://pubmed.ncbi.nlm.nih.gov/34779227
https://pubmed.ncbi.nlm.nih.gov/34779227
Autor:
Thomas J. Hope, Jorge E. Chacon, Jiang Qiu, Georgina L Dobek, Ewa Bryndza-Tfaily, David Watrous, Solange M. Simpson, Jonathan T. Su, Patrick F. Kiser, Dipu Karunakaran, Ronald S. Veazey, Samuel Sung
Publikováno v:
J Control Release
Long-acting antiretroviral implants could help protect high-risk individuals from HIV infection. We describe the design and testing of a long-acting reservoir subcutaneous implant capable of releasing cabotegravir for several months. We compressed ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58985dcaf5280e44108d724b2aab436f
https://doi.org/10.1016/j.jconrel.2020.12.024
https://doi.org/10.1016/j.jconrel.2020.12.024
Autor:
Ann M Carias, Shannon A Allen, Angela J Fought, Katarina Kotnik Halavaty, Meegan R Anderson, Maria L Jimenez, Michael D McRaven, Casey J Gioia, Tara R Henning, Ellen N Kersh, James M Smith, Lara E Pereira, Katherine Butler, S Janet M McNicholl, R Michael Hendry, Patrick F Kiser, Ronald S Veazey, Thomas J Hope
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005885 (2016)
Currently, there are mounting data suggesting that HIV-1 acquisition in women can be affected by the use of certain hormonal contraceptives. However, in non-human primate models, endogenous or exogenous progestin-dominant states are shown to increase
Externí odkaz:
https://doaj.org/article/80e89e6e2b914887bc6e62ce858014f7
Autor:
Kate Morrow Guthrie, Sara Vargas, Julia G Shaw, Rochelle K Rosen, Jacob J van den Berg, Patrick F Kiser, Karen Buckheit, Dana Bregman, Lara Thompson, Kathleen Jensen, Todd Johnson, Robert W Buckheit
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145642 (2015)
Intravaginal rings (IVRs) are currently under investigation as devices for the delivery of agents to protect against the sexual transmission of HIV and STIs, as well as pregnancy. To assist product developers in creating highly acceptable rings, we s
Externí odkaz:
https://doaj.org/article/849789a33d1a4eeda00630fb4e43eb6b
Autor:
Justin T Clark, Meredith R Clark, Namdev B Shelke, Todd J Johnson, Eric M Smith, Andrew K Andreasen, Joel S Nebeker, Judit Fabian, David R Friend, Patrick F Kiser
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e88509 (2014)
The HIV/AIDS pandemic and its impact on women prompt the investigation of prevention strategies to interrupt sexual transmission of HIV. Long-acting drug delivery systems that simultaneously protect womenfrom sexual transmission of HIV and unwanted p
Externí odkaz:
https://doaj.org/article/3f02cff4b85c4444ad40be1a69cc36d8
Autor:
Jining Zhang, Priya Srinivasan, Betsy C. Herold, Patrick F. Kiser, Chuong Dinh, James M. Smith, Ryan S. Teller, Janet M. McNicholl
Publikováno v:
Journal of Medical Primatology. 46:129-136
Background Intravaginal rings (IVR) for HIV prevention will likely be used by women on depot medroxyprogesterone acetate (DMPA) hormonal contraception. We used pigtailed macaques to evaluate the effects of DMPA on tenofovir disoproxil fumarate (TDF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cf5a66f5f19077060e6b33d8ab4ab67
https://doi.org/10.1111/jmp.12299
https://doi.org/10.1111/jmp.12299
Autor:
David Watrous, Jonathan T. Su, Mark A. Marzinke, Dipu Karunakaran, Georgina L Dobek, M. Melissa Peet, Ewa Bryndza Tfaily, Elizabeth Pearson, Jiang Qiu, Lakmini Widanapathirana, Ronald S. Veazey, Brooke Grasperge, Samuel Sung, Thomas J. Hope, Patrick F. Kiser, Solange M. Simpson, Charlette M. Cain
Publikováno v:
Antimicrobial Agents and Chemotherapy
We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d658c055dbaf0910c8864e01c2b040
https://pubmed.ncbi.nlm.nih.gov/31871073
https://pubmed.ncbi.nlm.nih.gov/31871073
Autor:
David Watrous, Solange M. Simpson, Lakmini Widanapathirana, Elizabeth Pearson, Jiang Qiu, Alex Evanoff, Jonathan T. Su, Patrick F. Kiser, Jorge E. Chacon, Dipu Karunakaran, Samuel Sung
Publikováno v:
Pharmaceutical Research
Purpose Sexual transmission of HIV has been clinically proven to be preventable with a once-daily oral tablet; however, missed doses dramatically increase the risk of HIV infection. Long-acting subcutaneous implants do not allow the user to miss a do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71904ec9ae0b0c1cdb4205475c901ae2
https://pubmed.ncbi.nlm.nih.gov/32296951
https://pubmed.ncbi.nlm.nih.gov/32296951
Autor:
Hendrik Streeck, Jeffrey R. Schneider, Kelly M. Fahrbach, Alison E. Mahan, Bronwyn M. Gunn, Thomas J. Hope, Shiv Pillai, Bruce D. Walker, Igal Szleifer, Anna Licht, Archer D. Smith, Neil L. Kelleher, Patrick F. Kiser, David C. Malaspina, Meegan R. Anderson, Ivan Zvonar, Anais Chapel, Marcus M. Karim, Todd J. Suscovich, Arthur Y. Kim, Galit Alter, Maryam Shansab, Marcus Altfeld, Jacquelynn Tedesco, Georg M. Lauer, Arangassery Rosemary Bastian
Publikováno v:
Mucosal immunology
Transmission of HIV across mucosal barriers accounts for the majority of HIV infections worldwide. Thus, efforts aimed at enhancing protective immunity at these sites are a top priority, including increasing virus-specific antibodies (Abs) and antivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1bb93c1fdafa0846489accf0e2c64
https://doi.org/10.1038/mi.2016.8
https://doi.org/10.1038/mi.2016.8