Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Patrick F. Dillon"'
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2014)
Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity. The mechanism by which insulin
Externí odkaz:
https://doaj.org/article/a0e1a9706b924aedae2f2eaab9fce71b
Autor:
Patrick F. Dillon
Specifically tailored to life science students, this textbook explains quantitative aspects of human biophysics with examples drawn from contemporary physiology, genetics and nanobiology. It outlines important physical ideas, equations and examples a
Autor:
Patrick F. Dillon, James P. Barger
Publikováno v:
ELECTROPHORESIS. 41:1170-1177
Water exchange between bulk water and water-ion complexes will be at equilibrium when the charge density of the complex surface equals the charge density of bulk water, producing a constant radius water-ion complex. This complex will migrate in an el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db87c7a20d039ef94f3dcba4bfe0343
https://doi.org/10.1002/elps.201900467
https://doi.org/10.1002/elps.201900467
Autor:
Patrick F Dillon, Robert Root-Bernstein, N Edward Robinson, William M Abraham, Catherine Berney
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15130 (2010)
RATIONALE: Previous in vitro research demonstrated that ascorbate enhances potency and duration of activity of agonists binding to alpha 1 adrenergic and histamine receptors. OBJECTIVES: Extending this work to beta 2 adrenergic systems in vitro and i
Externí odkaz:
https://doaj.org/article/f9ca3886e6854b52b0d76abf8c6b8319
Publikováno v:
Journal of Molecular Recognition. 29:296-302
The intracellular recycling of ascorbic acid from dehydroascorbic acid by the glutathione-glutathione reductase system has been well-characterized. We propose that extracellular recycling of ascorbic acid is performed in a similar manner by cysteine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0098b53d7757a5ff7ef441102455ecd
https://doi.org/10.1002/jmr.2530
https://doi.org/10.1002/jmr.2530
Publikováno v:
Current Drug Discovery Technologies. 11:293-307
Several different classes of compounds enhance the potency of aminergic receptor ligands three-fold or more and increase their duration of activity up to ten-fold. These enhancers include the vitamins ascorbic acid and folic acid, chelators such as e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c33fb59c800a919566b402c14cb834
https://doi.org/10.2174/157016381104150507121846
https://doi.org/10.2174/157016381104150507121846
Publikováno v:
Current Medicinal Chemistry
Several classes of compounds that have no intrinsic activity on aminergic systems nonetheless enhance the potency of aminergic receptor ligands three-fold or more while significantly increasing their duration of activity, preventing tachyphylaxis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9192bcb8ca4fb588b81d5fcd364e3f
https://doi.org/10.2174/0929867321666140826120604
https://doi.org/10.2174/0929867321666140826120604
Autor:
Patrick F. Dillon, James P. Barger
Publikováno v:
Cell calcium. 60(6)
The dehydration of ion-water complexes prior to ion channel transit has focused on channel protein-mediated dissociation of water. Ion dehydration by the membrane electric field has not previously been considered. Near membrane electric fields have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b70f977aa9418e13e5cdfa2a6a74b44
https://pubmed.ncbi.nlm.nih.gov/27683058
https://pubmed.ncbi.nlm.nih.gov/27683058
Publikováno v:
Drug Development Research. 69:242-250
We previously demonstrated that adrenergic and histaminergic receptors have an ascorbic acid (vitamin C) binding site on the first extracellular loop, immediately adjacent to the aminergic binding site. Binding of ascorbate to this site strongly pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7047809dd936af2429aa73974c1a770
https://doi.org/10.1002/ddr.20250
https://doi.org/10.1002/ddr.20250
Publikováno v:
Current Pharmaceutical Design. 14:55-62
Many examples of specific binding between small molecules are known that are associated with modified physiological and pharmacological activities. Conversely, the antagonism or synergism of small molecules is often correlated with specific binding b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa398f90ffcd853bcc055cf843251f4
https://doi.org/10.2174/138161208783330727
https://doi.org/10.2174/138161208783330727