Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Patrick F. Desmond"'
Autor:
Patrick F. Desmond, Megan A. Rizzo, Amanda Labuza, Robert J. Bloch, Joaquin Muriel, Allison E. Mancini, Michele L. Markwardt
Publikováno v:
Journal of Biological Chemistry. 292:10961-10972
SERCA1, the sarco(endo)plasmic reticulum Ca2+-ATPase of skeletal muscle, is essential for muscle relaxation and maintenance of low resting Ca2+ levels in the myoplasm. We recently reported that small ankyrin 1 (sAnk1) interacts with the sarco(endo)pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6a8af97dd1746d8b8fd4da77e81cc0
https://doi.org/10.1074/jbc.m117.783613
https://doi.org/10.1074/jbc.m117.783613
Autor:
Enrico Pierantozzi, Eric Estève, Valeria Marrocco, Shannon N. Bremner, Matthew Wright, Madison Clark, Vincenzo Sorrentino, Stephan Lange, Patrick F. Desmond, Jim Nguyen, Majid Ghassemian, Samuel R. Ward, Stephanie Myers, Jordan Blondelle
Publikováno v:
Communications Biology
Communications biology, vol 2, iss 1
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications biology, vol 2, iss 1
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Biological roles of obscurin and its close homolog Obsl1 (obscurin-like 1) have been enigmatic. While obscurin is highly expressed in striated muscles, Obsl1 is found ubiquitously. Accordingly, obscurin mutations have been linked to myopathies, where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a8f3dcb468488391616ebb455caf4e
http://europepmc.org/articles/PMC6509138
http://europepmc.org/articles/PMC6509138
Publikováno v:
Journal of Biological Chemistry. 290:27854-27867
Small ankyrin 1 (sAnk1) is a 17-kDa transmembrane (TM) protein that binds to the cytoskeletal protein, obscurin, and stabilizes the network sarcoplasmic reticulum in skeletal muscle. We report that sAnk1 shares homology in its TM amino acid sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf5caf67257e014aa4bcbd473998ab8
https://doi.org/10.1074/jbc.m115.676585
https://doi.org/10.1074/jbc.m115.676585
Autor:
Robert Kovelman, Patrick F. Desmond, Natalie J. Kennel, Juan P. Hinestrosa, Ellen B. Christie, Delia Ye, Michelle M. Nguyen, Alfred D. Kinana, Mark S. Schechter, David Chu, Chirag M. Shah, Osama Hlalah, John E. Doster, Rajaram Krishnan
Publikováno v:
Cancer Research. 79:1350-1350
There are significant limitations to the tools currently used to monitor clinical status and treatment response in late-stage non-small cell lung cancer (NSCLC) patients. Standard-of-care imaging is generally performed every few months, and emerging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c31711de94b1a25091d10f16505acb
https://doi.org/10.1158/1538-7445.am2019-1350
https://doi.org/10.1158/1538-7445.am2019-1350
Autor:
Allison E. Mancini, Robert J. Bloch, Amanda Labuza, Mark A. Rizzo, Patrick F. Desmond, Joaquin Muriel
Publikováno v:
Biophysical Journal. 116:382a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc6a107071aa0eb2e4ef2c7baa42aa3
https://doi.org/10.1016/j.bpj.2018.11.2073
https://doi.org/10.1016/j.bpj.2018.11.2073
Autor:
Rajaram Krishnan, Robert Turner, Robert Kovelman, Afshin Bahador, Patrick F. Desmond, Suren Uswatta, David Bodkin, Lyudmila Bazhenova, David Searson, James Madsen, Michelle M. Nguyen, Juan Pablo Hinestrosa, Delia Ye
Publikováno v:
Cancer Research. 78:3666-3666
We have developed a novel microfluidic technology that makes use of Alternating Current Electrokinetics (ACE) to isolate macromolecules such as high-molecular-weight DNA and protein complexes as well as nanoparticles, including cell-derived exosomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::805811d7a0301ac1a0fff6f0256541f9
https://doi.org/10.1158/1538-7445.am2018-3666
https://doi.org/10.1158/1538-7445.am2018-3666
Autor:
Eric J. Devaney, Ju Chen, Stephan Lange, Anush Velmurugan, Patrick F. Desmond, Nancy D. Dalton, Kirk L. Peterson, Yusu Gu, Stephanie Myers, Matthew Klos
Publikováno v:
Biophysical Journal. 112:122a
Obscurin is a giant myofibrillar protein important for sarcomere structure, signaling, and maintenance of sarcoplasmic reticulum (SR) organization. Surprisingly, obscurin knockout mice develop normally and only show signs of a mild skeletal muscle my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::471695d579253f7d9054090a1d7dcc58
https://doi.org/10.1016/j.bpj.2016.11.681
https://doi.org/10.1016/j.bpj.2016.11.681
Introduction: We adopted a proteomics-based approach to gain insights into phenotypic differences between A/J and B10.SJL murine dysferlinopathy models. Methods :W e optimized immunoblotting of dysferlin by preparing homoge- nates of the tibialis ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716a68eaeb7cdb040cd940dc6d1ed5c4
https://europepmc.org/articles/PMC4107149/
https://europepmc.org/articles/PMC4107149/
Autor:
Patrick F. Desmond, Sharad S. Deshpande, Charles B. Barham, Richard K. Gordon, Irwin Koplovitz, Julian R. Haigh, David E. Lenz, James P. Apland, Michael Adler
Publikováno v:
Chemico-biological interactions. 187(1-3)
Pyridostigmine bromide (PB) was approved by the U.S. Food and Drug Administration (FDA) in 2003 as a pretreatment in humans against the lethal effects of the irreversible nerve agent soman (GD). Organophosphate (OP) chemical warfare agents such as GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9928656cfe1e36f9cd9bdf01f75fe54f
https://pubmed.ncbi.nlm.nih.gov/20144889
https://pubmed.ncbi.nlm.nih.gov/20144889