Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Patrick Essletzbichler"'
Autor:
Patrick Essletzbichler, Vitaly Sedlyarov, Fabian Frommelt, Didier Soulat, Leonhard X Heinz, Adrijana Stefanovic, Benedikt Neumayer, Giulio Superti-Furga
Phagocytosis, the process of engulfing large particles by cells, is a multilayered biological activity driving tissue clearance and host defense. Dysregulation of phagocytosis is connected to autoimmunity, accumulation of toxic disease proteins, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d77b5da384ed5ed026615899fdf0f26
https://doi.org/10.1101/2022.09.08.507072
https://doi.org/10.1101/2022.09.08.507072
Autor:
Patrick Essletzbichler, Alice Y. Ting, David Benjamin Turitz Cox, Omar O. Abudayyeh, Aviv Regev, Joseph J. Belanto, Eric S. Lander, Max J. Kellner, Daniel F. Voytas, Feng Zhang, Julia Joung, Jonathan S. Gootenberg, Vanessa Verdine, Shuo Han
Publikováno v:
Nature. 550:280-284
RNA plays important and diverse roles in biology, but molecular tools to manipulate and measure RNA are limited. For example, RNA interference (RNAi)1-3 can efficiently knockdown RNAs, but it is prone to off-target effects4, and visualizing RNAs typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c3e0be91b07f7e31cb766647b1f203
https://doi.org/10.1038/nature24049
https://doi.org/10.1038/nature24049
Autor:
Omar O. Abudayyeh, Aviv Regev, Nina M. Donghia, Patrick Essletzbichler, James J. Collins, Jonathan S. Gootenberg, Nichole M. Daringer, Jeong Wook Lee, Jonathan Livny, Pardis C. Sabeti, Eugene V. Koonin, Feng Zhang, Deborah T. Hung, Julia Joung, Aaron J. Dy, Roby P. Bhattacharyya, Vanessa Verdine, Catherine A. Freije, Cameron Myhrvold
Publikováno v:
PMC
Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas13a (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31019a0dd1b654937f3715cd6cfb145a
https://doi.org/10.1126/science.aam9321
https://doi.org/10.1126/science.aam9321
Autor:
Johannes W. Bigenzahn, Patrick Essletzbichler, Ismet Srndic, Felix Kartnig, Leonhard X. Heinz, Pavel Kovarik, Enrico Girardi, Ulrich Goldmann, Paula Nunes-Hasler, Vitaly Sedlyarov, Ruth Eichner, Manuele Rebsamen, Nicolas Demaurex, Anna Moskovskich, Giulio Superti-Furga
Publikováno v:
Cell Host & Microbe, Vol. 23, No 6 (2018) pp. 766-774.e5
Cell Host & Microbe
Cell Host & Microbe
Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we identified the bicarbonate transporter SLC4A7, which is strongly induced upon macrophage differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81e778b6dbcb9b24ade287bde0a27b3
https://archive-ouverte.unige.ch/unige:109624
https://archive-ouverte.unige.ch/unige:109624
Autor:
Feng Zhang, Julia Joung, Ian Slaymaker, Sara E. Volz, Patrick Essletzbichler, Eugene V. Koonin, Kira S. Makarova, Bernd Zetsche, John van der Oost, Jonathan S. Gootenberg, Omar O. Abudayyeh, Aviv Regev
Publikováno v:
Cell 163 (2015) 3
PMC
Cell, 163(3), 759-771
PMC
Cell, 163(3), 759-771
The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize multiprotein complexes, whereas Class 2 effectors rely on single-component e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90b784deab30654d95300f6af2afc45
https://research.wur.nl/en/publications/cpf1-is-a-single-rna-guided-endonuclease-of-a-class-2-crispr-cas-
https://research.wur.nl/en/publications/cpf1-is-a-single-rna-guided-endonuclease-of-a-class-2-crispr-cas-
Autor:
Sebastian M.B. Nijman, Patrick Essletzbichler, Doris Chen, Bianca V. Gapp, Robert Kralovics, Thijn R. Brummelkamp, Tilmann Bürckstümmer, Federica Santoro, Tomasz Konopka
Publikováno v:
Genome Research
Near-haploid human cell lines are instrumental for genetic screens and genome engineering as gene inactivation is greatly facilitated by the absence of a second gene copy. However, no completely haploid human cell line has been described, hampering t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e454029b4e2df91ebab2a5dd373ded1e
http://ora.ox.ac.uk/objects/uuid:0e4622fd-2df7-4056-8513-69d9818ae748
http://ora.ox.ac.uk/objects/uuid:0e4622fd-2df7-4056-8513-69d9818ae748
Autor:
Vitaly Sedlyarov, Leonhard X. Heinz, Felix Kartnig, Charles E. Whitehurst, Adrijana Stefanovic, André C. Müller, Jun Li, Giulio Superti-Furga, Johannes W. Bigenzahn, Ariel Bensimon, F. James King, Patrick Essletzbichler, Manuele Rebsamen, Mattia D. Pizzagalli, M. Lamine Mbow, Konstantinos Papakostas, Ulrich Goldmann, JangEun Lee, Enrico Girardi, Stefania Scorzoni, Adrián César-Razquin, Utkarsh Kapoor
Publikováno v:
Nature
Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses1-3. Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0608af0032271285f98088b63af0156