Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Patrick Dorr"'
Autor:
Justin E. Ideozu, Mengzhen Liu, Bridget M. Riley-Gillis, Sri R. Paladugu, Fedik Rahimov, Preethi Krishnan, Rakesh Tripathi, Patrick Dorr, Hara Levy, Ashvani Singh, Jeffrey F. Waring, Aparna Vasanthakumar
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Limited understanding of the diversity of variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene across ancestries hampers efforts to advance molecular diagnosis of cystic fibrosis (CF). The consequences p
Externí odkaz:
https://doaj.org/article/3b6ab30fd82f46199da1babff1f4bf31
Autor:
Daniel Clark Files, Frank Tacke, Alexandra O'Sullivan, Patrick Dorr, William G Ferguson, William G Powderly
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010547 (2022)
Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has created a global pandemic infecting over 230 million people and costing millions of lives. Therapies to attenuate severe disease are desp
Externí odkaz:
https://doaj.org/article/1a96f9a38e594553b94d882c91ae3000
Autor:
Justin E. Ideozu, Mengzhen Liu, Bridget M. Riley-Gillis, Sri R. Paladugu, Fedik Rahimov, Preethi Krishnan, Rakesh Tripathi, Patrick Dorr, Hara Levy, Ashvani Singh, Jeffery F. Waring, Aparna Vasanthakumar
Limited understanding of the diversity ofCFTRvariants across ancestries hampers efforts to advance molecular diagnosis of cystic fibrosis (CF). The consequences pose a risk of delayed diagnoses and subsequently worsened health outcomes for patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df7a107e3d30692730710bc9ec9694f
https://doi.org/10.1101/2023.03.10.23287070
https://doi.org/10.1101/2023.03.10.23287070
Autor:
Manos Perros, David C. Pryde, Rob Webster, Francesca Perruccio, Michelle Y. Platts, Rhys M. Jones, Deborah Rodrigues, David V. Batchelor, David Ellis, Donald Stuart Middleton, David R. Fenwick, Patrick Dorr, Stupple Paul Anthony, Mike Westby, Anthony Wood, Helen J. Mason, Nicholas Smith, Martin Corless, Sebastien Galan, Peter T. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 54:67-77
Preventing entry of HIV into human host cells has emerged as an attractive approach to controlling viral replication. Maraviroc 1 is an approved antagonist of the human CCR5 receptor which prevents the entry of HIV. Herein, we report the design and d
Autor:
Manos Perros, Patrick Dorr
Publikováno v:
Expert Opinion on Drug Discovery. 3:1345-1361
The human immunodeficiency virus 1 (HIV-1) is the causative pathogen of AIDS, the world's biggest infectious disease killer. About 33 million people are infected worldwide, with 2.1 million deaths a year as a direct consequence. The devastating natur
Autor:
Patrick Dorr, Mike Westby, Manos Perros, Caroline Smith-Burchnell, Michael Mosley, Julie Mori, Marilyn Lewis, Mark Stockdale, Giuseppe Ciaramella
Publikováno v:
Journal of Virology. 81:2359-2371
Maraviroc is a CCR5 antagonist in clinical development as one of a new class of antiretrovirals targeting human immunodeficiency virus type 1 (HIV-1) coreceptor binding. We investigated the mechanism of HIV resistance to maraviroc by using in vitro s
Autor:
Manos Perros, Patrick Dorr, Paul J. Peters, W. Matthew Sullivan, Samantha J. Willey, Paul R. Clapham
Publikováno v:
Antiviral Research. 68:96-108
Highly active anti-retroviral therapy (HAART) has been very effective in reducing viral loads in human immunodeficiency virus (HIV)-1 patients. However, current therapies carry detrimental side effects, require complex drug regimes and are threatened
Autor:
Deborah R. Wysong, Tony Wood, Patrick R. Errada, Tanya Parkinson, Karen J. McGovern, Ian M. Willis, Ronald K. Blackman, Liping Wu, Alexandra E. Gould, Vala Thoroddsen, Timothy D. Ocain, Daniel Kornitzer, Lawrence R. Dick, Patrick Dorr, Christine E. Bulawa, Jing Pan, Ziva Weissman
Publikováno v:
Eukaryotic Cell. 2:256-264
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA polymerase (Pol) III from Saccharomyces cerevisiae .
Publikováno v:
Case Studies in Modern Drug Discovery and Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8496ead208fc517617db2d4d451eb5
https://doi.org/10.1002/9781118219683.ch9
https://doi.org/10.1002/9781118219683.ch9
Autor:
Marta Calado, María Dalila Espírito-Santo, Quirina Santos-Costa, Patrick Dorr, J. Miguel Azevedo-Pereira
Human immunodeficiency virus (HIV) entry into susceptible cells involves the interaction between viral envelope glycoproteins with CD4 and a chemokine receptor (coreceptor), namely CCR5 and CXCR4. This interaction has been studied to enable the disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4a720ebe0ef738dff2c8ffa195157d
https://europepmc.org/articles/PMC3332526/
https://europepmc.org/articles/PMC3332526/