Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Patrick Daum"'
Autor:
Sandra Schreiber, Patrick Daum, Heike Danzer, Manuela Hauke, Hans-Martin Jäck, Jürgen Wittmann
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1517 (2023)
MicroRNAs (miRNAs) are 21–25 nucleotide long non-coding ribonucleic acids that modulate gene expression by degrading transcripts or inhibiting translation. The miRNA miR-128, originally thought to be brain-specific, was later also found in immune c
Externí odkaz:
https://doaj.org/article/d01b0633d6d54308bf4d453d34740546
Autor:
Patrick Daum, Shannon R. Ottmann, Julia Meinzinger, Sebastian R. Schulz, Joana Côrte-Real, Manuela Hauke, Edith Roth, Wolfgang Schuh, Dirk Mielenz, Hans-Martin Jäck, Katharina Pracht
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We have previously shown that the microRNA (miRNA) processor complex consisting of the RNAse Drosha and the DiGeorge Critical Region (DGCR) 8 protein is essential for B cell maturation. To determine whether miRNA processing is required to initiate T
Externí odkaz:
https://doaj.org/article/8b042029acb9441b9ad755d9568f3a0c
Autor:
Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Bärbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jäck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff
The processes leading from disturbed B cell development to adult B cell progenitor acute lymphoblastic leukemia (BCP-ALL) are poorly understood. Here, we describe Irf4−/− mice as prone to developing BCP-ALL with age. Irf4−/− preB-I cells exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::019b2ff723d80862b81ffa903579885c
https://doi.org/10.1101/2022.02.16.480573
https://doi.org/10.1101/2022.02.16.480573
Autor:
Frederik Helmprobst, Hans-Martin Jäck, Andreas Neubauer, Maria Bieringer, Thorsten Stiewe, Marco Mernberger, Christoph Paul, Lisa Menke, Uta-Maria Bauer, Dennis Das Gupta, Nadine Bollig, Axel Pagenstecher, Federico Marini, Michael Wanzel, Andreas Burchert, Andrea Nist, Hartmann Raifer, Daniel Staudenraus, Matthias Klein, Michael Lohoff, Edith Roth, Bärbel Camara, Malte Buchholz, Patrick Daum, Tobias Bopp
How disturbances of B cell development provoke adult B acute lymphoblastic leukemia (B-ALL) remains poorly understood. Here we describe Irf4–/– mice as prone to developing B-ALL with age. Irf4–/– pro/preB cells exhibited impaired differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bafe58b8d57b37c741a4b4717fe64ab7
https://doi.org/10.21203/rs.3.rs-271184/v1
https://doi.org/10.21203/rs.3.rs-271184/v1
Autor:
Wolfgang Schuh, Dirk Mielenz, Dorothea Kindermann, Katharina Pracht, Joana Côrte-Real, Manuela Hauke, Jürgen Wittmann, Patrick Daum, Hans-Martin Jäck, Julia Meinzinger, Edith Roth, Sebastian R. Schulz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766e2be9b655bdab27103efe520af28b
https://doi.org/10.1002/eji.202048993/v2/response1
https://doi.org/10.1002/eji.202048993/v2/response1
Autor:
Katharina Pracht, Manuela Hauke, Joana Côrte-Real, Hans-Martin Jäck, Wolfgang Schuh, Dorothea Kindermann, Dirk Mielenz, Julia Meinzinger, Edith Roth, Sebastian R. Schulz, Jürgen Wittmann, Patrick Daum
Publikováno v:
European journal of immunologyReferences. 51(5)
Long-lived antibody-secreting plasma cells are essential to establish humoral memory against pathogens. While a regulatory transcription factor network has been established in plasma cell differentiation, the regulatory role of miRNAs remains enigmat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8382835fe3b8bfdb77a8ea44d8c880d7
https://pubmed.ncbi.nlm.nih.gov/33792033
https://pubmed.ncbi.nlm.nih.gov/33792033
Autor:
Patrick Daum
Der Klimawandel schreitet immer weiter voran. Als eine der Hauptursachen gilt der weltweit hohe CO2-Ausstoß. Viele Automobilhersteller arbeiten deshalb an umweltfreundlichen Lösungen wie Elektromotoren. Elektromobilität ist auf dem Vormarsch, stel
Autor:
Patrick Daum, Dorothea Reimer, Dirk Mielenz, Wolfgang Schuh, Manuela Hauke, Sebastian R. Schulz, Claudia Berek, Katharina Pracht, Julia Meinzinger, Hans-Martin Jäck, Joana Côrte-Real, Edith Roth
Publikováno v:
European journal of immunology. 47(8)
We provide a robust four-color fluorescence-based flow cytometry protocol that distinguishes viable dividing plasmablasts from nondividing plasma cells and, based on CD19 surface abundance, identifies two mature plasma cell populations in the spleen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81880e898516e5508fff35800223689
https://pubmed.ncbi.nlm.nih.gov/28787106
https://pubmed.ncbi.nlm.nih.gov/28787106
Autor:
Sven Brenner, Hans-Martin Jäck, Andreas Brandl, Jürgen Wittmann, Desmond Y H Yap, Sebastian R. Schulz, Michael R. Bösl, Patrick Daum, Wolfgang Schuh
Publikováno v:
European journal of immunology. 46(12)
microRNAs (miRNAs) are important posttranscriptional regulators during hematopoietic lineage commitment and lymphocyte development. Mature miRNAs are processed from primary miRNA transcripts in two steps by the microprocessor complex, consisting of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07a6937e73f50fe7178f78985574890
https://pubmed.ncbi.nlm.nih.gov/27641147
https://pubmed.ncbi.nlm.nih.gov/27641147
Autor:
Stephan Blüml, Tobias Rothe, Wolfgang Schuh, René E. M. Toes, Yoann Rombouts, Gerhard Krönke, Martin Herrmann, Patrick Daum, Iryna Magorivska, Erik Lönnblom, Axel J. Hueber, R Pfeifle, Kutty Selva Nandakumar, Martina Seefried, Gordon F. Heidkamp, Changrong Ge, Carolien A. M. Koeleman, Christoph Becker, Sybille Böhm, Stephan Culemann, Stefan Uderhardt, Rikard Holmdahl, Arnd Kleyer, Thomas Winkler, Benjamin Haugg, Georg Schett, Falk Nimmerjahn, Ulrike Harre, Anja Lux, Diana Dudziak, Hans Scherer, Jochen A. Ackermann, Manfred Wuhrer, Natacha Ipseiz
Publikováno v:
Nature Immunology
Nature Immunology, 18(1), 104-113
Nature Immunology, 18(1), 104-113
The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 subset of helper T cells as a decisive factor that controlled the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a514f35fd357ea3f5a8e6b906150d013