Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Patrick D. Skelton"'
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Pten, a gene associated with autism spectrum disorder, is an upstream regulator of receptor tyrosine kinase intracellular signaling pathways that mediate extracellular cues to inform cellular development and activity-dependent plasticity. We therefor
Externí odkaz:
https://doaj.org/article/c0ee692b54294944842d4608016b1db8
Publikováno v:
Cells, Vol 11, Iss 1, p 169 (2022)
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease with a similar clinical presentation and progression to idiopathic Parkinson’s disease, and common variation is linked to disease risk. Recapitulation of the genotype in
Externí odkaz:
https://doaj.org/article/98d70a4746ee4da1a208834b5a483f04
Autor:
Stephanie A. Getz, Kamran Tariq, Dylan H. Marchand, Conor R. Dickson, James R. Howe VI, Patrick D. Skelton, Wei Wang, Meijie Li, Jeremy M. Barry, Jennifer Hong, Bryan W. Luikart
Publikováno v:
J Neurosci
Phosphatase and tensin homolog (PTEN) is a major negative regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway. Loss-of-function mutations inPTENhave been found in a subset of patients with macrocep
Autor:
Alyssa M. Ash, Elena Regele-Blasco, Désirée R. Seib, Erin Chahley, Patrick D. Skelton, Bryan W. Luikart, Jason S. Snyder
Publikováno v:
Neurobiology of learning and memory.
Ongoing neurogenesis in the dentate gyrus (DG) subregion of the hippocampus results in a heterogenous population of neurons. Immature adult-born neurons (ABNs) have physiological and anatomical properties that may give them a unique role in learning.
Autor:
Chad R. Haney, Philipp Gutruf, Thomas Murickan, Mingzheng Wu, Patrick D. Skelton, Yevgenia Kozorovitskiy, Yonggang Huang, Jokubas Ausra, Roberto Peralta, Abraham Vázquez-Guardado, Raudel Avila, Xin Zhang, John A. Rogers
Publikováno v:
Proc Natl Acad Sci U S A
Wireless, battery-free, and fully subdermally implantable optogenetic tools are poised to transform neurobiological research in freely moving animals. Current-generation wireless devices are sufficiently small, thin, and light for subdermal implantat
Publikováno v:
Molecular psychiatry
Pten mutations are associated with autism spectrum disorder. Pten loss of function in neurons increases excitatory synaptic connectivity, contributing to an imbalance between excitation and inhibition. We aimed to determine whether Pten loss results
Publikováno v:
Mol Neuropsychiatry
PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse models that h
Publikováno v:
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Neurobiol Dis
Neurobiol Dis
Pten, a gene associated with autism spectrum disorder, is an upstream regulator of receptor tyrosine kinase intracellular signaling pathways that mediate extracellular cues to inform cellular development and activity-dependent plasticity. We therefor
Autor:
Bryan W. Luikart, Julia F. Litzky, Emily S. Li, L. Benjamin Hills, Sarah E. Streeter, Gilbert J. Rahme, Kyla R. Rodgers, Edmond Chipumuro, James R. Howe, Patrick D. Skelton, Grace B. Russo
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177661 (2017)
PLoS ONE
PLoS ONE
Neurogenesis is a highly-regulated process occurring in the dentate gyrus that has been linked to learning, memory, and antidepressant efficacy. MicroRNAs (miRNAs) have been previously shown to play an important role in the regulation of neuronal dev
Autor:
Christian P. Rizzuto, Stephanie A. Getz, Catherine J. Fricano-Kugler, Joseph S. Geller, Patrick D. Skelton, Bryan W. Luikart, Michael R. Williams, Meijie Li, Jeonghoon Lee
Publikováno v:
Scientific Reports
Retroviruses expressing a fluorescent protein, Cas9 and a small guide RNA are used to mimic nonsense PTEN mutations from autism patients in developing mouse neurons. We compare the cellular phenotype elicited by CRISPR-Cas9 to those elicited using sh