Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Patrick D. Sarmiere"'
Publikováno v:
Molecular Aspects of Medicine. 91:101148
Advances in genome sequencing have greatly facilitated the identification of genomic variants underlying rare neurodevelopmental and neurodegenerative disorders. Understanding the fundamental causes of rare monogenic disorders has made gene therapy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7155da2b3dfd154d06651fffd1b4d0b
https://doi.org/10.1016/j.mam.2022.101148
https://doi.org/10.1016/j.mam.2022.101148
Autor:
Ora Bernard, Patrick D. Sarmiere, Nathalie Moussi, Boris Sarcevic, James R. Bamburg, Rashmi Sampath, Sankar Maiti, Juliana Soosairajah, O'Neil Wiggan
Publikováno v:
The EMBO Journal. 24:473-486
Slingshot (SSH) phosphatases and LIM kinases (LIMK) regulate actin dynamics via a reversible phosphorylation (inactivation) of serine 3 in actin-depolymerizing factor (ADF) and cofilin. Here we demonstrate that a multi-protein complex consisting of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95a20c21a713da7c2e015f8f05d94cb
https://doi.org/10.1038/sj.emboj.7600543
https://doi.org/10.1038/sj.emboj.7600543
Publikováno v:
The Journal of Neuroscience. 24:10741-10749
The molecular mechanisms by which neurotrophins regulate growth cone motility are not well understood. This study investigated the signaling involved in transducing BDNF-induced increases of filopodial dynamics. Our results indicate that BDNF regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6fbd81b1c4be1caad97e1707b6eb3d
https://doi.org/10.1523/jneurosci.2836-04.2004
https://doi.org/10.1523/jneurosci.2836-04.2004
Publikováno v:
Experimental Cell Research. 294:392-405
The expression of endogenous LIM kinase 1 (LIMK1) protein was investigated in embryonic and adult mice using a rat monoclonal antibody (mAb), which recognizes specifically the PDZ domain of LIMK1 and not LIMK2. Immunoblotting analysis revealed widesp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ef703a08ca7cffcfbf2ecca7e5ea3d
https://doi.org/10.1016/j.yexcr.2003.11.024
https://doi.org/10.1016/j.yexcr.2003.11.024
Publikováno v:
Journal of Neurochemistry. 73:429-432
Sympathetic neurons undergo apoptosis when deprived of nerve growth factor (NGF). Inhibitors of RNA or protein synthesis block this death, suggesting that gene expression is important for apoptosis in this system. We have identified SM-20 as a new ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38f603b593c6f247f92ef74e39c0405
https://doi.org/10.1046/j.1471-4159.1999.0730429.x
https://doi.org/10.1046/j.1471-4159.1999.0730429.x
Analysis of the NF-κB and PI 3-Kinase/Akt Survival Pathways in Nerve Growth Factor-Dependent Neurons
Autor:
Patrick D. Sarmiere, Robert S. Freeman
Publikováno v:
Molecular and Cellular Neuroscience. 18:320-331
Nerve growth factor (NGF) readdition to NGF-deprived neurons can halt Jun N-terminal kinase (JNK) activation, cytochrome c release, and cell death through mechanisms that may involve phosphatidylinositol (PI) 3-kinase, Akt, and nuclear factor kappa B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b10533a566d09ecdc0f840da60cf26c
https://doi.org/10.1006/mcne.2001.1021
https://doi.org/10.1006/mcne.2001.1021
Publikováno v:
Cellular microbiology. 6(5)
Entry of Salmonella into mammalian cells is strictly dependent on the reorganization of actin cytoskeleton induced by a panel of Salmonella type III secreted proteins. Although several factors have been identified to be responsible for inducing the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a42554c5b8ac90f2f54f739ec57c65
https://pubmed.ncbi.nlm.nih.gov/15056216
https://pubmed.ncbi.nlm.nih.gov/15056216
Autor:
James R. Bamburg, Patrick D. Sarmiere
Publikováno v:
Journal of neurobiology. 58(1)
Actin and microtubules are major cytoskeletal elements of most cells including neurons. In order for a cell to move and change shape, its cytoskeleton must undergo rearrangements that involve breaking down and reforming filaments. Many recent reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587459357801f3f3d15714e6caa70ea6
https://pubmed.ncbi.nlm.nih.gov/14598374
https://pubmed.ncbi.nlm.nih.gov/14598374
Autor:
Michael T. Maloney, Patrick D. Sarmiere, Judith M. Sneider, Alisa E. Shaw, Barbara W. Bernstein, James R. Bamburg, Laurie S. Minamide, J.A Gonzalez, O'Neil Wiggan
Adenoviruses infect a wide range of cell types, do not require integration into the host cell genome, and can be produced as replication-deficient viruses capable of expressing transgenes behind any desired promoter. Thus, they are ideal for use in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0aa796c8c274a4e9779dd8380d7bbad
https://doi.org/10.1016/s0091-679x(03)01019-7
https://doi.org/10.1016/s0091-679x(03)01019-7
Autor:
Patrick D, Sarmiere, James R, Bamburg
Publikováno v:
Neuron. 35(1)
LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84065988eeea6292f1abeedc0440e5a5
https://pubmed.ncbi.nlm.nih.gov/12123613
https://pubmed.ncbi.nlm.nih.gov/12123613