Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Patrick D. McMullen"'
Autor:
A. Rasim Barutcu, Michael B. Black, Raymond Samuel, Scott Slattery, Patrick D. McMullen, Andy Nong
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Toxicological risk assessment increasingly utilizes transcriptomics to derive point of departure (POD) and modes of action (MOA) for chemicals. One essential biological process that allows a single gene to generate several different RNA isoforms is c
Externí odkaz:
https://doaj.org/article/5f23c4aec13642cb8bbdccfc53f82b72
Autor:
Chantel I. Nicolas, Matthew W. Linakis, Melyssa S. Minto, Kamel Mansouri, Rebecca A. Clewell, Miyoung Yoon, John F. Wambaugh, Grace Patlewicz, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell III
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard an
Externí odkaz:
https://doaj.org/article/c77f706ac85c49c3bc5d018511b024a1
Autor:
Marjory Moreau, Pankajini Mallick, Marci Smeltz, Saad Haider, Chantel I. Nicolas, Salil N. Pendse, Jeremy A. Leonard, Matthew W. Linakis, Patrick D. McMullen, Rebecca A. Clewell, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
High-throughput (HT) in vitro to in vivo extrapolation (IVIVE) is an integral component in new approach method (NAM)-based risk assessment paradigms, for rapidly translating in vitro toxicity assay results into the context of in vivo exposure. When c
Externí odkaz:
https://doaj.org/article/fcd7d8b3f0a74dc38672d8c4d72eb9ac
Autor:
Michael B. Black, Melvin E. Andersen, Salil N. Pendse, Susan J. Borghoff, Michael Streicker, Patrick D. McMullen
Publikováno v:
Data in Brief, Vol 38, Iss , Pp 107420- (2021)
The National Toxicology Program (NTP) reported that chronic exposure to varying dietary concentrations of 4-methylimidazole (4-MeI) increased lung tumors in female and male mice [1]. In this study, mice (male and female B6C3F1 mice) were either admin
Externí odkaz:
https://doaj.org/article/14f8cca609cc494895eaded385e8c96a
Autor:
Saad Haider, Michael B. Black, Bethany B. Parks, Briana Foley, Barbara A. Wetmore, Melvin E. Andersen, Rebecca A. Clewell, Kamel Mansouri, Patrick D. McMullen
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Efficient high-throughput transcriptomics (HTT) tools promise inexpensive, rapid assessment of possible biological consequences of human and environmental exposures to tens of thousands of chemicals in commerce. HTT systems have used relatively small
Externí odkaz:
https://doaj.org/article/b8192d7fd04c4982a628c821724c6ce5
Autor:
Rick A Fasani, Carolina B Livi, Dipanwita eRoy Choudhury, Andre eKleensang, Mounir eBouhifd, Salil N Pendse, Patrick D McMullen, Melvin E Anderson, Thomas eHartung, Michael eRosenberg
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2016)
The Human Toxome Project is part of a long-term vision to modernize toxicity testing for the 21st century. In the initial phase of the project, a consortium of six academic, commercial, and government organizations has partnered to map pathways of to
Externí odkaz:
https://doaj.org/article/bcdb716b74ee43fca18fc25e3f4ee6b5
Autor:
Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen, Scott D. Slattery
Publikováno v:
Toxicology. 481
Time, cost, ethical, and regulatory considerations surrounding in vivo testing methods render them insufficient to meet existing and future chemical safety testing demands. There is a need for the development of in vitro and in silico alternatives to
Publikováno v:
ALTEX.
Environmental factors play a substantial role in determining cardiovascular health, but data informing the risks presented by environmental toxicants is insufficient. In vitro new approach methodologies (NAMs) offer a promising approach with which to
Autor:
Melvin E. Andersen, Patrick D. McMullen, Salil N. Pendse, Michael B. Black, Michael Streicker, Susan J. Borghoff
Publikováno v:
Data in Brief
Data in Brief, Vol 38, Iss, Pp 107420-(2021)
Data in Brief, Vol 38, Iss, Pp 107420-(2021)
The National Toxicology Program (NTP) reported that chronic exposure to varying dietary concentrations of 4-methylimidazole (4-MeI) increased lung tumors in female and male mice [1]. In this study, mice (male and female B6C3F1 mice) were either admin
Autor:
Chad Deisenroth, Michael B Black, Salil Pendse, Linda Pluta, Sam M Witherspoon, Patrick D McMullen, Russell S Thomas
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114133 (2014)
Adipose stem cell (ASC) differentiation is necessary for the proper maintenance and function of adipose tissue. The procurement and characterization of multipotent ASCs has enabled investigation into the molecular determinants driving human adipogene
Externí odkaz:
https://doaj.org/article/b878e9e421d54d96a17e08829650ea5e