Addressing challenges of training a new generation of clinician‐innovators through an interdisciplinary medical technology design program: Bench‐to‐Bedside

Autor: Patrick D Loftus, Craig T Elder, Troy D’Ambrosio, John T Langell

Publikováno v: Clinical and Translational Medicine, Vol 4, Iss 1, Pp n/a-n/a (2015)

AbstractGraduate medical education has traditionally focused on training future physicians to be outstanding clinicians with basic and clinical science research skills. This focus has resulted in substantial knowledge gains, but a modest return on in

Externí odkaz: https://doaj.org/article/e0c390a1869d446d8efa72d4f41a1f4e

Use of Oxandrolone to Promote Growth in Neonates following Surgery for Complex Congenital Heart Disease: An Open-Label Pilot Trial

Autor: Richard V. Williams, Matthew W. Linakis, Xiaoming Sheng, Linda M. Lambert, Phillip T. Burch, Catherine M.T. Sherwin, L. LuAnn Minich, Patrick D. Loftus, Michael G. Spigarelli

Publikováno v: Congenital Heart Disease. 11:693-699

Objective Malnutrition and poor weight gain, common in neonates following repair of complex congenital heart disease (CHD), are associated with increased morbidity and mortality. Oxandrolone, an anabolic steroid, improves weight gain in older childre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02097707f6a0b10f8b3208f2819cb68a
https://doi.org/10.1111/chd.12376

Neonatal Flail Tricuspid Valve: Diagnosis and Management

Autor: Cammon B. Arrington, Aditya K. Kaza, Patrick D. Loftus

Publikováno v: The Annals of Thoracic Surgery. 98:1098-1101

Flail tricuspid valve in the neonate is a rare and often fatal condition requiring early diagnosis and intervention. We report 3 infants born without antenatal signs of cardiovascular compromise. Severe hypoxemia developed within hours of birth due t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14ab8aea36a2c2c74d7ba2bc38fcfe7
https://doi.org/10.1016/j.athoracsur.2013.11.003

Use of Oxandrolone to Promote Growth in Neonates following Surgery for Complex Congenital Heart Disease: An Open-Label Pilot Trial

Autor: Phillip T, Burch, Michael G, Spigarelli, Linda M, Lambert, Patrick D, Loftus, Catherine M, Sherwin, Matthew W, Linakis, Xiaoming, Sheng, L, LuAnn Minich, Richard V, Williams

Publikováno v: Congenital heart disease. 11(6)

Malnutrition and poor weight gain, common in neonates following repair of complex congenital heart disease (CHD), are associated with increased morbidity and mortality. Oxandrolone, an anabolic steroid, improves weight gain in older children at high-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d445d2283d78be10ed24e1e1ed37d86c
https://pubmed.ncbi.nlm.nih.gov/27257953

Mechanical stretch triggers rapid epithelial cell division through Piezo1

Autor: Patrick D. Loftus, J. Lindblom, K. Edes, Michael J. Redd, Swapna Aravind Gudipaty, Jody Rosenblatt, V. Krishnegowda, C. F. Davey

Publikováno v: Gudipaty, S A, Lindblom, J, Loftus, P D, Redd, M J, Edes, K, Davey, C F, Krishnegowda, V & Rosenblatt, J 2017, ' Mechanical stretch triggers rapid epithelial cell division through Piezo1 ', Nature, vol. 543, no. 7643, pp. 118-121 . https://doi.org/10.1038/nature21407
Nature

Despite acting as a barrier for the organs they encase, epithelial cells turn over at some of the fastest rates in the body. However, epithelial cell division must be tightly linked to cell death to preserve barrier function and prevent tumour format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8c4aa13ea79ede17e7f72d2a48c5f0
https://pubmed.ncbi.nlm.nih.gov/28324742