Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Patrick Connick"'
1
Identification of the contact region responsible for the formation of the homomeric CYP1A2•CYP1A2 complex
Autor: Charles S Lott, Aratrika Saha, James R. Reed, Wayne L. Backes, J. Patrick Connick
Publikováno v: Biochem J
Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a sigmoidal response as a function of NADPH-cytochrome P450 reductase (POR) conc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16db68aca41200be3c5994a0e3a187e1
https://doi.org/10.1042/bcj20210269
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5
Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1
Autor: Wayne L. Backes, J. Patrick Connick, James R. Reed, George F. Cawley
Publikováno v: Biochem J
P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when compared with P450 and HO-1, they must effectively compete for POR to function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c68e45142220ef43157232aa6dc459
https://pubmed.ncbi.nlm.nih.gov/33394027
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6
Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes
Autor: Wayne L. Backes, James R. Reed, J. Patrick Connick
Publikováno v: Drug Metabolism and Disposition. 46:197-203
Cytochromes P450s (P450s) catalyze oxygenation reactions via interactions with their redox partners. However, other proteins, particularly other P450s, also have been shown to form complexes that modulate P450 function. Previous studies showed that C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efd2b4bfc1ea8dd8273998edd5bd4bf
https://doi.org/10.1124/dmd.117.078642
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9
Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1
Autor: J. Patrick Connick, George F. Cawley, Wayne L. Backes, James R. Reed
Publikováno v: The Journal of Biological Chemistry
Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum-bound enzymes that rely on the same protein, NADPH-cytochrome P450 reductase (POR), to provide the electrons necessary for substrate metabolism. Although the HO-1 and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38845c4bba48dfd6a1cc255c03a5261
https://doi.org/10.1074/jbc.ra120.015911
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