Výsledky vyhledávání - "Patrick Chène"

Akademický článek

The role of lysine palmitoylation/myristoylation in the function of the TEAD transcription factors

Autor: Yannick Mesrouze, Gustavo Aguilar, Marco Meyerhofer, Fedir Bokhovchuk, Catherine Zimmermann, Patrizia Fontana, Alexandra Vissières, Hans Voshol, Dirk Erdmann, Markus Affolter, Patrick Chène

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

Abstract The TEAD transcription factors are the most downstream elements of the Hippo pathway. Their transcriptional activity is modulated by different regulator proteins and by the palmitoylation/myristoylation of a specific cysteine residue. In thi

Externí odkaz: https://doaj.org/article/f02b86fa3df24797a39ed636e8605ba1

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Akademický článek

Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD

Autor: Michael Feichtinger, Andreas Beier, Mario Migotti, Matthias Schmid, Fedir Bokhovchuk, Patrick Chène, Robert Konrat

Publikováno v: iScience, Vol 25, Iss 4, Pp 104099- (2022)

Summary: Yes-associated protein (YAP) is a partly intrinsically disordered protein (IDP) that plays a major role as the downstream element of the Hippo pathway. Although the structures of the complex between TEA domain transcription factors (TEADs) a

Externí odkaz: https://doaj.org/article/29d36cbaa80447f8b4aa1c02d947df57

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Akademický článek

Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD

Autor: Yannick Mesrouze, Fedir Bokhovchuk, Marco Meyerhofer, Patrizia Fontana, Catherine Zimmermann, Typhaine Martin, Clara Delaunay, Dirk Erdmann, Tobias Schmelzle, Patrick Chène

Publikováno v: eLife, Vol 6 (2017)

TEAD (TEA/ATTS domain) transcription factors are the most distal effectors of the Hippo pathway. YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pa

Externí odkaz: https://doaj.org/article/bd70a4e9206a4019ba44712c116f4c9f

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