Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Patrick Caspers"'
Autor:
Georg Rueedi, Cornelia Zumbrunn, Daniel Ritz, Patrick Caspers, Christina Stamm, Daniela Krüsi
Publikováno v:
ChemMedChem. 16:891-897
Ribosomal protein synthesis is an important target in antibacterial drug discovery. Numerous natural products have served as starting points for the development of antibiotics. We report here the total synthesis of xenocoumacin 1, a natural product t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69494b4009395058b1db587618592745
https://doi.org/10.1002/cmdc.202000793
https://doi.org/10.1002/cmdc.202000793
Autor:
Joel Roesslein, Daniel Ritz, Katja Zerbe, Georg Rueedi, Karl Gademann, Patrick Caspers, Hideki Miyatake-Ondozabal, Hiromu Hattori
Publikováno v:
Angewandte Chemie. 130:11186-11190
The macrocyclic antibiotic mangrolide A has been described to exhibit potent activity against a number of clinically important Gram-negative pathogens. Reported is the first enantioselective total synthesis of mangrolide A and derivatives. Salient fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8339cd966e39835c2617fc19b0e364
https://doi.org/10.1002/ange.201805770
https://doi.org/10.1002/ange.201805770
Autor:
Daniel Ritz, Daniel Boehringer, Georg Rueedi, Marc Leibundgut, Patrick Caspers, Daniel Bur, Alain Scaiola, Hans H. Locher
Publikováno v:
Scientific Reports
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Oxazolidinones are synthetic antibiotics used for treatment of infections caused by Gram-positive bacteria. They target the bacterial protein synthesis machinery by binding to the peptidyl transferase centre (PTC) of the ribosome and interfering with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b93ea395c9457be0a589546006738b0
https://doi.org/10.1038/s41598-019-42155-4
https://doi.org/10.1038/s41598-019-42155-4
Autor:
Philippe Pfaff, Sarah Diggelmann, Hans H. Locher, Daniel Ritz, Daniel Bur, Georg Rueedi, Patrick Caspers
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Cadazolid (CDZ) is a new antibiotic currently in clinical development for the treatment of Clostridium difficile infections. CDZ interferes with the bacterial protein synthesis machinery. The aim of the present study was to identify resistance mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2972c0889973ad604ad75534d0b8e1e6
https://doi.org/10.1128/aac.00384-17
https://doi.org/10.1128/aac.00384-17
Autor:
Philippe Pfaff, Andreja Knezevic, Susanne Schroeder, Hans H. Locher, Thierry Bruyère, Patrick Caspers, Daniel Ritz, Wolfgang Keck
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:901-908
Cadazolid is a new oxazolidinone-type antibiotic currently in clinical development for the treatment of Clostridium difficile -associated diarrhea. Here, we report investigations on the mode of action and the propensity for spontaneous resistance dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c67db593b7c5653c935ff9f362e3977
https://doi.org/10.1128/aac.01831-13
https://doi.org/10.1128/aac.01831-13
Autor:
Michael Härtlein, Patrick Caspers, Michael A. Kron, Malcolm G. P. Page, Franck Danel, Claude Nuoffer
Publikováno v:
Current Drug Discovery Technologies. 8:66-75
Aminoacyl-tRNA synthetases (AARSs) are a structurally heterogeneous family of enzymes present in prokaryotes, archaea and eukaryotes. They catalyze the attachment of tRNA to its corresponding amino acid via an aminoacyl adenylate intermediate. Errors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88c832f55342d28c58ebb313482730b
https://doi.org/10.2174/157016311794519947
https://doi.org/10.2174/157016311794519947
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:4949-4952
BAL0030543, BAL0030544, and BAL0030545 are dihydrophthalazine inhibitors with in vitro potency against gram-positive pathogens. The MIC 50 s for methicillin (meticillin)-sensitive Staphylococcus aureus , methicillin-resistant Staphylococcus aureus ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af0408245b88dead3b328212f4c0d92
https://doi.org/10.1128/aac.00845-09
https://doi.org/10.1128/aac.00845-09
Autor:
Joo Hyun Lim, Oliver von Ahsen, Nikolaus Pfanner, Hans-Joachim Schönfeld, Joachim Rassow, Falk Martin, Patrick Caspers
Publikováno v:
Journal of Molecular Biology. 297:809-818
Cyclophilins accelerate slow protein folding reactions in vitro by catalyzing the cis/trans isomerization of peptidyl-prolyl bonds. Cyclophilins were reported to be involved in a variety of cellular functions, including the promotion of protein foldi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fece4518724f3e79ccbf8d70cee2aac
https://doi.org/10.1006/jmbi.2000.3574
https://doi.org/10.1006/jmbi.2000.3574
Publikováno v:
BioTechniques. 28:498-505
A restriction site-free cloning method has been developed for inserting a PCR product into a vector flexibly and precisely at any desired location with high efficiency. The method uses a pair of DNA integration primers with two portions. The 3′ por
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9188487d2f8048dd40153dc77104973
https://doi.org/10.2144/00283st08
https://doi.org/10.2144/00283st08
Autor:
Christian Wagner, Wolfgang Keck, Kurt Amrein, Juliette Molnos, Martin Stieger, Nicholas Flint, Markus Kamber, Patrick Caspers, Antoine de Saizieu, Roland Lange
Publikováno v:
Gene. 237:223-234
In bacteria, adaptive responses to environmental stimuli are often initiated by two-component signal transduction systems (TCS). The prototypical TCS comprises two proteins: a histidine kinase (HK, hk) and a response regulator (RR rr). Recent researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cae6734559c5fcab044a20f20250937
https://doi.org/10.1016/s0378-1119(99)00266-8
https://doi.org/10.1016/s0378-1119(99)00266-8