Výsledky vyhledávání - "Patrick C. Roche"

Akademický článek

Loss of Immunoreactivity for Human Calmodulin-Like Protein is an Early Event in Breast Cancer Development

Autor: Michael S. Rogers, Margaret A. Foleyt, Thomas B. Crotty, Lynn C. Hartmannt, James N. Ingle, Patrick C. Roche, Emanuel E. Strehler

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 1, Iss 3, Pp 220-225 (1999)

Cell proliferation requires calmodulin, a protein that regulates calcium-dependent enzymes involved in signal transduction pathways in eukaryotic cells. Calmodulin-like protein (CLIP) is found in certain epithelial cell types, including normal breast

Externí odkaz: https://doaj.org/article/f0ad7ecb4aa744b681ab049da2090a79

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The LH/hCG Receptor

Autor: Robert J. Ryan, Patrick C. Roche

Publikováno v: Luteinizing Hormone Action and Receptors ISBN: 9780429285684

This chapter focuses on the Lutropin (LH)/human chorionic gonadotropin (hCG) receptor itself and largely ignore events subsequent to the binding reaction. Evidence for the existence of gonadotropin receptors began to accumulate in 1940 when S. M. Sei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba19eda23fc686a594dbdfa63c0c9d5e
https://doi.org/10.1201/9780429285684-2

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Metallographic in situ hybridization

Autor: James Pettay, Richard D. Powell, William C. Powell, Raymond R. Tubbs, Patrick C. Roche, James F. Hainfeld, Thomas M. Grogan

Publikováno v: Human Pathology. 38:1145-1159

Metallographic methods, in which a target is visualized using a probe or antibody that deposits metal selectively at its binding site, offers many advantages for bright-field in situ hybridization (ISH) detection as well as for other labeling and det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b2f55c47128ec77542afe650e067c1
https://doi.org/10.1016/j.humpath.2007.05.004

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A New Rabbit Monoclonal Antibody (4B5) for the Immunohistochemical (IHC) Determination of the HER2 Status in Breast Cancer: Comparison With CB11, Fluorescence In Situ Hybridization (FISH), and Interlaboratory Reproducibility

Autor: David J. Dabbs, Katherine M. Scott, Shannon Tarr, Thomas M. Grogan, Raymond R. Tubbs, Richard W. Brown, David G. Hicks, Raymond B. Nagle, William C. Powell, Patrick C. Roche, Tristin Williams, Sarah M. Short, Simas Laniauskas, Nichole Prescott, James Pettay

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 15:94-102

The 2 methodologies in current clinical use to assess HER2 status in breast cancer are: fluorescence in situ hybridization (FISH) (gene amplification) and immunohistochemistry (protein over-expression). A consistent finding has been that 3% to 15% of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20c4818ea8e419b3fabbaf36812eefa5
https://doi.org/10.1097/pai.0b013e31802ced25

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The specificity of interphase FISH translocation probes in formalin fixed paraffin embedded tissue sections is readily assessed using automated staining and scoring of tissue microarrays constructed from murine xenografts

Autor: Eric Swain, Margaret Loftus, Marek Skacel, James Pettay, Thomas M. Grogan, Raymond R. Tubbs, James R. Cook, Gillian Paine, Patrick C. Roche, Todd S. Barry

Publikováno v: Journal of Molecular Histology. 38:159-165

Implementation of interphase fluorescence in situ hybridization (FISH) assays in the clinical laboratory requires validation against established methods. Validation tools in common use include exchange of consecutive sections with another institution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c679cc233db7ed4ebdb90f04105c444
https://doi.org/10.1007/s10735-006-9066-1

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Altered expression of connexin subtypes in mesial temporal lobe epilepsy in humans

Autor: Aaron A. Cohen-Gadol, Joseph E. Parisi, Nicholas M. Wetjen, Stephen D. Weigand, Fredric B. Meyer, Frederic Collignon, Patrick C. Roche, W. Richard Marsh, Gregory D. Cascino

Publikováno v: Journal of Neurosurgery. 105:77-87

Object The causes of epileptic events remain unclear. Much in vitro and in vivo experimental evidence suggests that gap junctions formed by connexins (Cxs) between neurons and/or astrocytes contribute to the generation and maintenance of seizures; ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b272910b60bd1ba2b94f9738921561d
https://doi.org/10.3171/jns.2006.105.1.77

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The CD117 Immunohistochemistry Tissue Microarray Survey for Quality Assurance and Interlaboratory Comparison: A College of American Pathologists Cell Markers Committee Study

Autor: Patrick C. Roche, Raymond R. Tubbs, Robert R. Rickert, David M. Dorfman, Patrick L. Fitzgibbons, Michael Linden, Eric D. Hsi, Marilyn M. Bui

Publikováno v: Archives of Pathology & Laboratory Medicine. 130:779-782

Context.—We have developed tissue microarray-based surveys to allow laboratories to compare their performance in staining predictive immunohistochemical markers, including proto-oncogene CD117 (c-kit), which is characteristically expressed in gastr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d9f57b4db972e39e44b5e727ba7fcd
https://doi.org/10.5858/2006-130-779-tcitms

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Immunohistochemistry: Principles and Advances

Autor: Patrick C. Roche, Eric D. Hsi, Bourke L. Firfer

Publikováno v: Manual of Molecular and Clinical Lab Immunology. :396-402

This chapter presents current, practical methods that are applicable for performance of quality immunostains in the modern automated immunohistochemistry (IHC) laboratory. The cross-links are believed to be responsible for masking antibody-binding ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::622a7d01aa712e3b41348bdaa4762bc5
https://doi.org/10.1128/9781555815905.ch45

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Analytical Validation and Interobserver Reproducibility of EnzMet GenePro

Autor: James F. Hainfeld, Raymond R. Tubbs, David G. Hicks, Thomas M. Grogan, Brian J. Yoder, Lisa Rybicki, Erinn Downs-Kelly, Jonathan Myles, James Pettay, Patrick C. Roche, Joseph J. Sreenan, Marek Skacel, Richard D. Powell

Publikováno v: The American Journal of Surgical Pathology. 29:1505-1511

Fluorescence in situ hybridization (FISH) has both excellent sensitivity and specificity in detecting HER2 gene amplification in invasive breast carcinoma. FISH has not been widely implemented in clinical practice because of reagent costs and the spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bf4c46d5d525773a3eb915d2f1ee69
https://doi.org/10.1097/01.pas.0000172294.67409.4f

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The Influence of Polysomy 17 on HER2 Gene and Protein Expression in Adenocarcinoma of the Breast

Autor: David G. Hicks, Marek Skacel, Thomas M. Grogan, Raymond R. Tubbs, Patrick C. Roche, Brian J. Yoder, Mark H. Stoler, Erinn Downs-Kelly

Publikováno v: American Journal of Surgical Pathology. 29:1221-1227

Breast carcinomas with amplification of HER2 on chromosome 17 are associated with HER2 protein overexpression, adversely affecting prognosis and predicting response to Herceptin therapy. Chromosome 17 polysomy is encountered in assessing HER2 gene st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b8a8a118f4de40f71e0bed0ba91197
https://doi.org/10.1097/01.pas.0000165528.78945.95

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