Výsledky vyhledávání - "Patrick C. Mahon"

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

Autor: Anna Staniszewska, Lisa Baker, Jonathan D. Moore, James Murray, Patrick C. Mahon, Terence Shaw, Paul Brough, Alan Surgenor, Michael Wood, Ben Davis, Jalanie D’Alessandro, Natalia Matassova, Macias Alba

Publikováno v: Scopus-Elsevier
Oncotarget

Pyruvate dehydrogenase kinase (PDK) is a pivotal enzyme in cellular energy metabolism that has previously been implicated in cancer through both RNAi based studies and clinical correlations with poor prognosis in several cancer types. Here, we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a89876a6f42b6b5319184f7f142c89
https://doi.org/10.18632/oncotarget.2656

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Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation

Autor: Nicholas R. Lemoine, Vipul Bhakta, Patrick C. Mahon, Patrick Baril, Rathi Gangeswaran, Claude Chelala, G Kelly, K Caulee, Tomohiko Harada

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2007, 96 (2), pp.373-382. ⟨10.1038/sj.bjc.6603563⟩

International audience; Pancreatic ductal adenocarcinoma (PDAC) is characterised pathologically by a marked desmoplastic stromal reaction that significantly reduces the sensitivity and specificity of cytogenetic analysis. To identify genetic alterati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033736b77f9a16a1d249e5fae415f640
https://doi.org/10.1038/sj.bjc.6603563

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Intrinsic Chemoresistance to Gemcitabine Is Associated with Decreased Expression of BNIP3 in Pancreatic Cancer

Autor: S. Lattimore, Nicholas R. Lemoine, Seiki Matsuno, Masanori Akada, Tatjana Crnogorac-Jurcevic, Rita Lopes, Makoto Sunamura, Patrick C. Mahon

Publikováno v: Clinical Cancer Research. 11:3094-3101

Purpose: Although chemotherapy with gemcitabine is a common mode of treatment of pancreatic cancer, 75% of patients do not benefit from this therapy. It is likely that the sensitivity of cancer cells to gemcitabine is determined by a number of differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd445cd69afeb49d5f7ac12e14c4a56
https://doi.org/10.1158/1078-0432.ccr-04-1785

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OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α

Autor: Balaji Krishnamachary, Jane Oh, Mia Pearson, Gregg L. Semenza, Brian Kelly, Amato J. Giaccia, Denise A. Chan, Patrick C. Mahon, Jin Hyen Baek

Publikováno v: Molecular Cell. 17(4):503-512

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan species. HIF-1 mediates changes in gene transcription in response to changes in cellular oxygenation. The half-life of the HIF-1alpha subunit is dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc56e1e301e1539dee7e9f7a1ee08b23

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S100A4 Contributes to the Suppression of BNIP3 Expression, Chemoresistance, and Inhibition of Apoptosis in Pancreatic Cancer

Autor: Claude Chelala, Krishna Caulee, Tomohiko Harada, Vipul Bhakta, Nicholas R. Lemoine, Patrick Baril, Patrick C. Mahon

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2007, 67 (14), pp.6786-6795. ⟨10.1158/0008-5472.CAN-07-0440⟩

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that is characterized by a particularly marked resistance to chemotherapy. We previously showed an association between decreased expression of BNIP3 and chemoresistance in PDAC cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd4e17d135b277375d9f77c9ecd9aeb
https://hal.archives-ouvertes.fr/hal-02086365

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Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway

Autor: Patrick Baril, Hemant M. Kocher, Nicholas R. Lemoine, Rathi Gangeswaran, Holger Kalthoff, Patrick C. Mahon, M Zhu, Tatjana Crnogorac-Jurcevic, Tomohiko Harada, K Caulee

Publikováno v: Oncogene. 26(14)

Pancreatic ductal adenocarcinoma is a devastating disease, characterized by a rapid progression and poor treatment response. Using gene expression profiling of pancreatic cancer tissues, we previously identified periostin as a potential diagnostic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fafbcb71f9296e5d07c62a93704460f
https://pubmed.ncbi.nlm.nih.gov/17043657

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FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Autor: Kiichi Hirota, Gregg L. Semenza, Patrick C. Mahon

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes under hypoxic conditions. O2-dependent binding of the von Hippel-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd32555a23680f15774f7b659e1c7c2
https://europepmc.org/articles/PMC312814/

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

Autor: Panthea Taghavi, Kelly Chiles, Erik Laughner, Patrick C. Mahon, Gregg L. Semenza

Publikováno v: Molecular and cellular biology. 21(12)

Angiogenesis is essential for tumorigenesis as well as metastasis (11, 16, 64), and vascular density is an important prognostic factor in breast cancer (19, 27, 58, 59). Vascular endothelial growth factor (VEGF) plays a major role in tumor angiogenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9971995da459a3c30542f7930e0d8e30
https://pubmed.ncbi.nlm.nih.gov/11359907

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Abstract B155: VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and demonstrates context-dependent cytotoxicity to cancer cells

Autor: Jonathan Moore, Natalia Massanova, Macias Alba, Paul Brough, Ben Davis, Anna Staniszewska, James Murray, Patrick C. Mahon, Michael Wood, Alan Surgenor, Lisa Baker, Jalanie D’Alessandro, Terence Shaw

Publikováno v: Molecular Cancer Therapeutics. 12:B155-B155

Pyruvate dehydrogenase kinase (PDK) regulates the activity of the pyruvate dehydrogenase complex (PDC) through phosphorylation of three serine residues on the E1α subunit, resulting in decreased activity. The expression of all four mammalian isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b5e8b08b86976f37f095f59205108db
https://doi.org/10.1158/1535-7163.targ-13-b155

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