Výsledky vyhledávání - "Patrick C Reid"

Akademický článek

The discovery and structural basis of two distinct state-dependent inhibitors of BamA

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract BamA is the central component of the essential β-barrel assembly machine (BAM), a conserved multi-subunit complex that dynamically inserts and folds β-barrel proteins into the outer membrane of Gram-negative bacteria. Despite recent advanc

Externí odkaz: https://doaj.org/article/bf48c6d78a39468c81c644c4c61faa56

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Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors†

Autor: Samuel Hintermann, Andreas Marzinzik, Johannes Ottl, Joerg Kallen, Therese-Marie Stachyra, Patrick C. Reid, Stephan Ruetz, Anselm F. L. Schneider, Christian P. R. Hackenberger, Christoph E. Dumelin, Sebastien Ripoche

Publikováno v: RSC Chemical Biology

Mouse double minute 2 homolog (MDM2, Hdm2) is an important negative regulator of the tumor suppressor p53. Using a mRNA based display technique to screen a library of >1012in vitro-translated cyclic peptides, we have identified a macrocyclic ligand t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c0089311703a726113d94f5b84104
http://europepmc.org/articles/PMC8637822

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Design of Thioether Cyclic Peptide Scaffolds with Passive Permeability and Oral Exposure

Autor: Christian M. Gampe, Jingzhou Li, Patel Tajesh Jayprakash, Jakal Amin, Charles Babu, Lihua Yang, Eugene Liu, Andrei Golosov, Katsumasa Nakajima, David Nettleton, Patrick C. Reid, Lauren G. Monovich, Flyer Alec

Publikováno v: Journal of Medicinal Chemistry. 64:2622-2633

Advances in the design of permeable peptides and in the synthesis of large arrays of macrocyclic peptides with diverse amino acids have evolved on parallel but independent tracks. Less precedent combines their respective attributes, thereby limiting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dd9795db77b2153f204b31c1dd80d9
https://doi.org/10.1021/acs.jmedchem.0c01505

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A new modular radiographic classification of adult idiopathic scoliosis as an extension of the Lenke classification of adolescent idiopathic scoliosis

Autor: James Lin, Louis F. Amorosa, Meghan Cerpa, Michael P. Kelly, Lawrence G. Lenke, Richard Menger, Griffin R. Baum, Peter D. Angevine, Marc D. Dyrszka, Christopher E. Mandigo, Patrick C. Reid, Zeeshan M. Sardar, Joseph A Osorio

Publikováno v: Spine Deformity. 9:175-183

To propose and test the reliability of a radiographic classification system for adult idiopathic scoliosis. A three-component radiographic classification for adult idiopathic scoliosis consisting of curve type, a lumbosacral modifier, and a global al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e749ea38ac7793e5bd8375dccc7668d
https://doi.org/10.1007/s43390-020-00181-7

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Akademický článek

Association of active γ-secretase complex with lipid rafts

Autor: Yasuomi Urano, Ikuo Hayashi, Noriko Isoo, Patrick C. Reid, Yoshikazu Shibasaki, Noriko Noguchi, Taisuke Tomita, Takeshi Iwatsubo, Takao Hamakubo, Tatsuhiko Kodama

Publikováno v: Journal of Lipid Research, Vol 46, Iss 5, Pp 904-912 (2005)

Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet clear, several studies have provided evidence for the involvement of cholesterol-rich lipid rafts in the production of amy

Externí odkaz: https://doaj.org/article/437b6b409817495dbd404afba2ab5136

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Akademický článek

Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts

Autor: Yoshio Yamauchi, Catherine C.Y. Chang, Michi Hayashi, Sumiko Abe-Dohmae, Patrick C. Reid, Ta-Yuan Chang, Shinji Yokoyama

Publikováno v: Journal of Lipid Research, Vol 45, Iss 10, Pp 1943-1951 (2004)

Differential regulation has been suggested for cellular cholesterol and phospholipid release mediated by apolipoprotein A-I (apoA-I)/ABCA1. We investigated various factors involved in cholesterol mobilization related to this pathway. ApoA-I induced a

Externí odkaz: https://doaj.org/article/11044ae0feed4d01950467b71c93054e

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Akademický článek

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain

Autor: Patrick C. Reid, Naomi Sakashita, Shigeki Sugii, Yoshiko Ohno-Iwashita, Yukiko Shimada, William F. Hickey, Ta-Yuan Chang

Publikováno v: Journal of Lipid Research, Vol 45, Iss 3, Pp 582-591 (2004)

Niemann-Pick type C (NPC) is a neurodegenerative disorder characterized by progressive accumulation of cholesterol, gangliosides, and other lipids in the central nervous system and visceral organs. In the NPC1 mouse model, neurodegeneration and neuro

Externí odkaz: https://doaj.org/article/bea23713b1544e268d826f433828d7b1

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