Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice

Autor: Dieter Schmoll, Nicole Ziegler, Benoit Viollet, Marc Foretz, Patrick C. Even, Dalila Azzout‐Marniche, Andreas Nygaard Madsen, Martin Illemann, Karen Mandrup, Michael Feigh, Jörg Czech, Heiner Glombik, Jacob A. Olsen, Wolfgang Hennerici, Klaus Steinmeyer, Ralf Elvert, Tamara R. Castañeda, Aimo Kannt

Publikováno v: Hepatology Communications, Vol 4, Iss 7, Pp 1056-1072 (2020)

The worldwide obesity and type 2 diabetes epidemics have led to an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD covers a spectrum of hepatic pathologies ranging from simple steatosis to nonalcoholic steatohepatitis, characterized by fi

Externí odkaz: https://doaj.org/article/9426e7d8200a4cacaf75487e613184ae

Role of liver AMPK and GCN2 kinases in the control of postprandial protein metabolism in response to mid-term high or low protein intake in mice

Autor: Tristan Chalvon-Demersay, Claire Gaudichon, Joanna Moro, Patrick C. Even, Nadezda Khodorova, Julien Piedcoq, Benoit Viollet, Julien Averous, Anne-Catherine Maurin, Daniel Tomé, Marc Foretz, Pierre Fafournoux, Dalila Azzout-Marniche

Publikováno v: European Journal of Nutrition
European Journal of Nutrition, 2023, 62 (1), pp.407-417. ⟨10.1007/s00394-022-02983-z⟩
European Journal of Nutrition, 2022, ⟨10.1007/s00394-022-02983-z⟩

International audience; Purpose Protein synthesis and proteolysis are known to be controlled through mammalian target of rapamycin, AMP-activated kinase (AMPK) and general control non-derepressible 2 (GCN2) pathways, depending on the nutritional cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae0b894dfe8565b4ca7f2cdb54639ef
https://hal.science/hal-04157343

Protein-carbohydrate interaction effects on energy balance, FGF21, IGF-1, and hypothalamic gene expression in rats

Autor: Patrick C. Even, Claire Gaudichon, Catherine Chaumontet, Dalila Azzout-Marniche, Joséphine Gehring, Julien Piedcoq

Publikováno v: AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, In press, ⟨10.1152/ajpendo.00246.2021⟩

International audience; Amino acids are involved in energy homeostasis, just as are carbohydrates and lipids. Therefore, mechanisms controlling protein intake should operate independently and in combination with systems controlling overall energy int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6401fd048f312d007380e0328da25ddd
https://doi.org/10.1152/ajpendo.00246.2021

Influence de la teneur en protéines de l’alimentation sur le contrôle de la prise alimentaire et la régulation du poids

Autor: Patrick C. Even, Claire Gaudichon, Joséphine Gehring

Publikováno v: Cahiers de Nutrition et de Diététique
Cahiers de Nutrition et de Diététique, Elsevier Masson, 2020, 55 (5), pp.223-232. ⟨10.1016/j.cnd.2020.08.001⟩

International audience; The protein requirement is generally defined as the amount necessary to maintain the body's protein pool. However, under free choice conditions, animal models often ingest more protein than required for nitrogen balance (10 %�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575559968463ddcc9a8c37ac56dba66a
https://doi.org/10.1016/j.cnd.2020.08.001

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo

Autor: Marc Foretz, Patrick C. Even, Benoit Viollet

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 9, p 2826 (2018)

The energy sensor AMP-activated protein kinase (AMPK) is a key player in the control of energy metabolism. AMPK regulates hepatic lipid metabolism through the phosphorylation of its well-recognized downstream target acetyl CoA carboxylase (ACC). Alth

Externí odkaz: https://doaj.org/article/39245bcde81c4b44b7f7a2f2de175fa4