Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Patrick Burrola"'
Autor:
Greg Lemke, Patrick Burrola, Kaisa E. Happonen, Nasun Hah, Youtong Huang, Ling Huang, Axel Nimmerjahn, Carolyn O’Connor
Publikováno v:
Nature immunology
Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer’s disease and its mouse models, induced expression of Ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee20c04f15cc8b45604686200c8c4ad3
http://europepmc.org/articles/PMC8102389
http://europepmc.org/articles/PMC8102389
Autor:
Sheng Miao, Lawrence Fourgeaud, Patrick Burrola, Shani Stern, Yuhan Zhang, Kaisa Happonen, Sammy Weiser Novak, Fred Gage, Greg Lemke
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43e000f27d7d16cef805c6d1577ea2ce
https://doi.org/10.2139/ssrn.4030044
https://doi.org/10.2139/ssrn.4030044
Autor:
Greg Lemke, Anna Zagórska, Rafael Mayoral, Paqui G. Través, Lidia Jiménez-García, Patrick Burrola, Bryan L. Copple, Francisco J. Tapia, Jenna D. Strickland
The TAM receptor tyrosine kinases (RTK) Mer and Axl have been implicated in liver disease, yet our understanding of their roles in liver homeostasis and injury is limited. We therefore examined the performance of Mer and Axl mutant mice during aging,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dd1ba2f54ba4bdd8f2ff3a068a99aa
https://doi.org/10.1101/2020.03.13.990143
https://doi.org/10.1101/2020.03.13.990143
Autor:
Greg Lemke, Anna Zagórska, Paqui G. Través, Joanne Oh, Lidia Jiménez-García, Jenna D. Strickland, Bryan L. Copple, Rafael Mayoral, Francisco J. Tapia, Patrick Burrola
Publikováno v:
Life Science Alliance
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Genome-wide association studies have implicated the TAM receptor tyrosine kinase (RTK) Mer in liver disease, yet our understanding of the role that Mer and its related RTKs Tyro3 and Axl play in liver homeostasis and the response to acute injury is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda7c2200e51d570ca478c1449d99a3e
https://pubmed.ncbi.nlm.nih.gov/32571802
https://pubmed.ncbi.nlm.nih.gov/32571802
Autor:
Greg Lemke, Yusuf Tufail, Humberto Leal-Bailey, Lawrence Fourgeaud, Patrick Burrola, Axel Nimmerjahn, Carla V. Rothlin, Paqui G. Través, Perri Callaway, Erin D. Lew, Anna Zagórska
Publikováno v:
Nature. 532:240-244
Microglia are damage sensors for the central nervous system (CNS), and the phagocytes responsible for routine non-inflammatory clearance of dead brain cells. Here we show that the TAM receptor tyrosine kinases Mer and Axl regulate these microglial fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957e009ac4fe003fb9a1b6e23706786c
https://doi.org/10.1038/nature17630
https://doi.org/10.1038/nature17630
Publikováno v:
Genes & Development. 22:3147-3157
Adhesion between epithelial cells mediates apical–basal polarization, cell proliferation, and survival, and defects in adhesion junctions are associated with abnormalities from degeneration to cancer. We found that the maintenance of specialized ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e532231f8cb6a11c9f6b878067953f
https://doi.org/10.1101/gad.1700108
https://doi.org/10.1101/gad.1700108
Publikováno v:
Nature. 431:847-853
The highly ordered wiring of retinal ganglion cell (RGC) neurons in the eye to their synaptic targets in the superior colliculus of the midbrain has long served as the dominant experimental system for the analysis of topographic neural maps1,2,3. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef40bd5e06e76ef1e4bbf8bd66d4e2b
https://doi.org/10.1038/nature02957
https://doi.org/10.1038/nature02957
Autor:
Paqui G. Través, Erin D. Lew, Patrick Burrola, Greg Lemke, Joseph Schlessinger, Jennifer Oh, Irit Lax, Anna Zagórska
Publikováno v:
eLife, Vol 3 (2014)
eLife
eLife
The TAM receptor tyrosine kinases Tyro3, Axl, and Mer regulate key features of cellular physiology, yet the differential activities of the TAM ligands Gas6 and Protein S are poorly understood. We have used biochemical and genetic analyses to delineat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ea20347e143e490a9867d37761f9a3
https://doi.org/10.7554/elife.03385
https://doi.org/10.7554/elife.03385
Autor:
Trevor J. Kilpatrick, Kuo-Fen Lee, Surinda S Cheema, Greg Lemke, Merja Soilu-Hanninen, Simon S. Murray, Peter J Maycox, Daniel E. Syroid, Patrick Burrola, Tamara Bucci, Steven Petratos
Publikováno v:
Scopus-Elsevier
Schwann cells express the low-affinity neurotrophin receptor (p75), but no role for either the neurotrophins or their cognate receptors in Schwann cell development has been established. We have found that Schwann cells isolated from postnatal day 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9310cb0c8a6c9b93c2dccd16136920a2
https://doi.org/10.1523/jneurosci.20-15-05741.2000
https://doi.org/10.1523/jneurosci.20-15-05741.2000