Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Patrick Bingham"'
Autor:
Alexei Brooun, Ketan S. Gajiwala, Ya-Li Deng, Wei Liu, Ben Bolaños, Patrick Bingham, You-Ai He, Wade Diehl, Nicole Grable, Pei-Pei Kung, Scott Sutton, Karen A. Maegley, Xiu Yu, Al E. Stewart
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.
Externí odkaz:
https://doaj.org/article/845df6d19e6c440e8657bbebe46e34a8
Publikováno v:
Frontiers: The Interdisciplinary Journal of Study Abroad; Jul2023, Vol. 35 Issue 2, p29-39, 11p
Publikováno v:
Frontiers: The Interdisciplinary Journal of Study Abroad; Jul2023, Vol. 35 Issue 2, p1-13, 13p
Publikováno v:
Frontiers: The Interdisciplinary Journal of Study Abroad; Jul2023, Vol. 35 Issue 2, p14-21, 8p
Autor:
Nelson C. Brunsting, Porshè L. Chiles, J. Kline Harrison, Marcia K. Crippen, Sonali Kathuria, W. Patrick Bingham, Shinji Katsumoto, Aiai Chen, Ian Holmes, Lambert Li
Publikováno v:
International Journal of Intercultural Relations. 92:101745
Autor:
Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand thei
Autor:
Michael R. Collins, Robert Steven Kania, Connie Fan, Sutton Scott Channing, Dominique Verhelle, Kephart Susan Elizabeth, Martin James Wythes, Shuiwang Wang, Karen A. Maegley, Lisa Nguyen, Daniel Tyler Richter, A.E. Stewart, Pei-Pei Kung, Buwen Huang, Shikhar Sharma, Shinji Yamazaki, Ya-Li Deng, Rita Grantner, Patrick Bingham, Robert Arnold Kumpf, Penney Khamphavong, Jinjiang Zhu, Dac M. Dinh, Manfred Kraus, Wei Liu, Sean Uryu, Jillian E. Spangler, Wenyue Hu, Hui Wang, Robert A. Rollins, Cody Krivacic, Zehnder Luke Raymond, Neal W. Sach, Alexei Brooun, John Sherrill, Shijian Ren, Martin A. Edwards, Huichun Zhu, Ketan S. Gajiwala, Shuibo Xin, Hovhannes J. Gukasyan
Publikováno v:
Journal of Medicinal Chemistry. 61:650-665
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Autor:
Karen L. White, Sean Uryu, Pei-Pei Kung, Melanie de Silva, Ian P. Street, Hieu Lam, Jane E. Visvader, Ylva E. Bozikis, Catalina Carrasco-Pozo, Karen A. Maegley, Geoffrey J. Lindeman, Shikhar Sharma, Anne K. Voss, Paul Stupple, Natalie Nady, Elizabeth Allan, Olan Dolezal, Chin Wee Tan, Elliot Surgenor, Yong Zhang, Alexandra E. Stupple, Yuqing Yang, Amanda Rickard, Michelle Ang Camerino, Brendon J. Monahan, Showkhin Khan, Thomas A Paul, Hendrik Falk, François Vaillant, Laura MacPherson, Zhenxiong Wang, Dawson Sarah-Jane, James R. Whittle, Jay Chung, Melissa J. Davis, Mark A. Dawson, Eric Greenwald, Thomas S. Peat, Vicky M. Avery, Tim Thomas, Haikuo Zhang, Rachel Lagiakos, Patrick Bingham, Matthew L. Dennis, Bin Ren, Miriam S. Butler, Susan A. Charman, Soroor Hediyeh-Zadeh, Stewart D. Nuttall
Publikováno v:
Cancer Research. 81:1130-1130
KAT6A is a lysine histone acetyltransferase (HAT) of the MYST family of HATs. KAT6A, and its paralog KAT6B, have been shown to acetylate histone H3K23Ac and regulate diverse biological processes, including transcription, cell-cycle progression, stem
Autor:
Nelson S. Bell, Daniel T. Yonemoto, Roger E. Cramer, Michael Luke Neville, Timothy J. Boyle, Samuel Patrick Bingham, Gregory Stillman, Jeremiah M. Sears, LaRico J. Treadwell
Publikováno v:
Polyhedron. 131:59-73
The synthesis of a series of lanthanide trifluoroacetic acid (H-TFA) derivatives which contain only the TFA and its conjugate acid has been developed. From the reaction of Ln(N(SiMe3)2)3 with an excess amount of H-TFA, the products were identified as
Autor:
Mark A. Rodriguez, Samuel Patrick Bingham, Jeremiah M. Sears, Timothy J. Boyle, Roger E. Cramer, Michael Luke Neville, Todd M. Alam
Publikováno v:
Polyhedron. 118:52-60
A series of hydrated hexafluoro-iso-propoxide (hfip) lanthanide complexes was synthesized from the amide-alkoxide exchange reaction of the lanthanide bis-trimethylsilyl amide dissolved in toluene and an excess amount of H-hfip. The products were isol