Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Patrick Bherer"'
Autor:
François Normand-Lauzière, Frédérique Frisch, Sébastien M Labbé, Patrick Bherer, René Gagnon, Stephen C Cunnane, André C Carpentier
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10956 (2010)
It has been proposed that abnormal postprandial plasma nonesterified fatty acid (NEFA) metabolism may participate in the development of tissue lipotoxicity and type 2 diabetes (T2D). We previously found that non-diabetic offspring of two parents with
Externí odkaz:
https://doaj.org/article/ac7a9a3922b84b06a274292f9f62fb91
Autor:
Yannis Trakadis, Walla Al-Hertani, Christiane Auray-Blais, Paula J. Waters, Serge Gravel, Annette Feigenbaum, Michael T. Geraghty, Catherine Brunel-Guitton, Patrick Bherer, Thomas M. Kitzler, Komudi Siriwardena, Nathan McIntosh, Osama Y. Al-Dirbashi
Publikováno v:
JIMD Reports ISBN: 9783662575765
Glutaric aciduria type 3 (GA3) is associated with decreased conversion of free glutaric acid to glutaryl-coA, reflecting deficiency of succinate-hydroxymethylglutarate coA-transferase, caused by variants in the SUGCT (C7orf10) gene. GA3 remains less
Autor:
Kerry A. Pierce, Clary B. Clish, Michael B. Powner, Lucy P. Evans, Marin L. Gantner, Alan B. Packard, Edith Aguilar, Jin Sung Kim, Zhuo Shao, Jing Chen, Zhongjie Fu, Samuel B. Burnim, Ye Sun, Bruno Maranda, Aimee M. Juan, Martin Friedlander, Przemyslaw Sapieha, Christian G. Hurst, Nicholas Saba, Emile Levy, Colman J. Hatton, Flavio A. Rezende, Thomas Fredrick, Gauri Patel, Marcus Fruttiger, Patrick Bherer, Lois E.H. Smith, Zhenghao Cui, Michel Boisvert, Kristis Vevis, Jean-Sébastien Joyal
Publikováno v:
Nature medicine
Tissues with high metabolic rates often use lipid as well as glucose for energy, conferring a survival advantage during feast and famine.1 Current dogma suggests that high-energy consuming photoreceptors depend on glucose.2,3 Here we show that retina
Autor:
Christiane Auray-Blais, Yan An, Joe T.R. Clarke, David S. Millington, Haoyue H. Zhang, René Gagnon, Patrick Bherer, Sarah P. Young
Publikováno v:
Molecular Genetics and Metabolism. 102:49-56
Mucopolysaccharidoses (MPSs) are complex storage disorders caused by specific lysosomal enzyme deficiencies, resulting in the accumulation of glycosaminoglycans (GAGs) in urine, plasma, as well as in various tissues. We devised and validated a straig
Autor:
Nadia Fortin, Carl Saint-Louis, Annick Landry, René Gagnon, Gilles Olsen, Sylvain Bernard, Patrick Bherer, Eric Marsault, Véronique Plourde, Gilles Berthiaume, Martin Brassard, Robert Deziel, Axel Mathieu, Gérald Villeneuve, Xiaowen Peng, Hamid R. Hoveyda, Mark Peterson, Graeme L. Fraser, François Bilodeau, Ruoxi Lan, Shridhar Bhat, Annie Doucet, Maude Gauthier, Yves L. Dory, David Lonergan, Shigui Li, Sylvie Beaubien, Luc Ouellet, Pierre Deslongchamps, Alexandre Drouin, Fabrice Galaud, Sophie Beauchemin, Manon Champagne, Kamel Benakli, Mahesh Ramaseshan, Laurence Foucher, Jean François Pinault, Martin Vezina, Daniel Fortin, Zhigang Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4731-4735
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studie
Autor:
Eric Marsault, Kamel Benakli, Graeme L. Fraser, Annick Landry, Sophie Beauchemin, Mahesh Ramaseshan, Laurence Foucher, Xiaowen Peng, Jean François Pinault, Martin Brassard, Daniel F. Veber, Martin Vezina, René Gagnon, Shridhar Bhat, Hamid R. Hoveyda, Carl Saint-Louis, Mark Peterson, Patrick Bherer, Sylvie Beaubien, Axel Mathieu, Luc Ouellet, Zhigang Wang
Publikováno v:
Journal of medicinal chemistry. 54(24)
High-throughput screening of Tranzyme Pharma's proprietary macrocycle library using the aequorin Ca2+-bioluminescence assay against the human ghrelin receptor (GRLN) led to the discovery of novel agonists against this G-protein coupled receptor. Earl
Publikováno v:
Clinical Biochemistry. 47:142
Autor:
André C. Carpentier, Patrick Bherer, René Gagnon, Frédérique Frisch, François Normand-Lauzière, Sébastien M. Labbé, Stephen C. Cunnane
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10956 (2010)
PLoS ONE
PLoS ONE
Background It has been proposed that abnormal postprandial plasma nonesterified fatty acid (NEFA) metabolism may participate in the development of tissue lipotoxicity and type 2 diabetes (T2D). We previously found that non-diabetic offspring of two p
Autor:
Yan An, Haoyue Zhang, Christiane Auray-Blais, René Gagnon, Patrick Bherer, Joe T.R. Clarke, Sarah P. Young, David S. Millington
Publikováno v:
Molecular Genetics and Metabolism. 99:S9