Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patrick Bernardelli"'
Autor:
Elisabeth Genet, Laurent Pradier, Delphine Ibghi, Matilde Lopez-Grancha, Jean-François Sabuco, David Machnik, Patrick Bernardelli, Valerie Roudieres, AIain Krick, Carine Vincent, Nicolas Moindrot, Véronique Taupin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 378(3)
In Alzheimer disease (AD), the double-strand RNA-dependent kinase protein kinase R (PKR )/EIF2AK2 is activated in brain with increased phosphorylation of its substrate eukaryotic initiation factor 2α (eIF2α). AD risk-promoting factors, such as ApoE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eb6928909760a598d793da26b0e1a0
https://pubmed.ncbi.nlm.nih.gov/34531308
https://pubmed.ncbi.nlm.nih.gov/34531308
Autor:
Marc Daumas, Claire Andersen, Amandine Guérinot, Patrick Bernardelli, Janine Cossy, Vincent Ferey
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2020, 22 (15), pp.6021-6025. ⟨10.1021/acs.orglett.0c02115⟩
Organic Letters, American Chemical Society, 2020, 22 (15), pp.6021-6025. ⟨10.1021/acs.orglett.0c02115⟩
The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6520c10282caa7950309bcc33425d0
https://hal.archives-ouvertes.fr/hal-03197964
https://hal.archives-ouvertes.fr/hal-03197964
Autor:
Jérôme Marrot, Laurent Schio, Patrick Bernardelli, Elsa Anselmi, Cédric Simon, Bruce Pégot, Emmanuel Magnier
Publikováno v:
European Journal of Organic Chemistry. 2017:6319-6326
The trifluoromethylthio group is of rising interest in medicinal, agrochemical, and materials chemistry. Although several strategies for the introduction of this functional group have been described, new synthetic methods are needed. A novel ionic li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::759890a95ef12730f41153142dc91900
https://doi.org/10.1002/ejoc.201701222
https://doi.org/10.1002/ejoc.201701222
Autor:
Amandine Guérinot, Patrick Bernardelli, Janine Cossy, Vincent Ferey, Marc Daumas, Claire Andersen
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2019, 21 (7), pp.2285-2289. ⟨10.1021/acs.orglett.9b00579⟩
Organic Letters, American Chemical Society, 2019, 21 (7), pp.2285-2289. ⟨10.1021/acs.orglett.9b00579⟩
International audience; A cobalt-catalyzed cross-coupling between alkyl iodides and cyclopropyl, cyclobutyl, and alkenyl Grignard reagents is disclosed. The reaction allows the introduction of strained rings on a large panel of primary and secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775f8d09503d72015b58b65544c79cd7
https://hal.archives-ouvertes.fr/hal-02533172
https://hal.archives-ouvertes.fr/hal-02533172
Autor:
Nicolas Moindrot, Carine Vincent, Valerie Roudieres, Philippe Goniot, Elisabeth Genet, Mati Lopez-Grancha, Delphine Ibghi, Patrick Bernardelli, Veronique Taupin
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aef6f49e7a34b3cfc265a4384cf7d316
https://doi.org/10.1016/j.jalz.2017.06.1266
https://doi.org/10.1016/j.jalz.2017.06.1266
Autor:
Bernadette Bertin, Anita Tertre, Nga Pham, Françoise Berlioz-Seux, Moulay Idrissi, Patrick Bernardelli, Arnaud Descours, Edwige Lorthiois, Mei Li, Pierre Ducrot, Chrystelle Oliveira, Magali Coupe, François Moreau, Eric Chevalier, Fabrice Vergne, Emmanuelle Proust, Patrick Berna, Abdel-Kader Mafroud
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4627-4631
The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b645e96fe4aad63c13696befaf5e5e
https://doi.org/10.1016/j.bmcl.2004.07.010
https://doi.org/10.1016/j.bmcl.2004.07.010
Autor:
Magali Coupe, Bernadette Bertin, Arnaud Descours, François Moreau, Patrick Bernardelli, Edwige Lorthiois, Patricia Soulard, Patrick Berna, Roger Wrigglesworth, Anita Tertre, Abdel-Kader Mafroud, Lamia Heuze, Emmanuelle Proust, Chrystelle Oliveira, Fabrice Vergne, Moulay Idrissi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4623-4626
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe38a476d80dbc5773e675bdb38f8ed6
https://doi.org/10.1016/j.bmcl.2004.07.011
https://doi.org/10.1016/j.bmcl.2004.07.011
Autor:
Ajith C Manage, Roger Wrigglesworth, Patrick Bernardelli, Edwige Lorthiois, Fabrice Vergne, Michael Bladon
Publikováno v:
Tetrahedron: Asymmetry. 15:1451-1455
(R,R)- and (S,S)-trans-3-Aminocyclohexanol were prepared via an enzymatic resolution of (±)-trans-1-acetoxy-3-benzylamido-cyclohexane with >95% enantiomeric excess.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f4e56b771bcf4bd043ea5539f8d3417
https://doi.org/10.1016/j.tetasy.2004.03.034
https://doi.org/10.1016/j.tetasy.2004.03.034
Autor:
Fabrice Gallou, Patrick Bernardelli, Raymond W. Doskotch, Tim Lange, Brian Dyck, Dirk Friedrich, Jiong Yang, Leo A. Paquette, Oscar M. Moradei
Publikováno v:
Journal of the American Chemical Society. 123:9021-9032
An enantioselective synthetic route to the thermodynamically most stable diastereomer of the structure assigned to sclerophytin A (5) has been realized. The required tricyclic ketone 33 was prepared by sequential Tebbe-Claisen rearrangement of lacton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa895182ada3241dc1bd9b1e5c38148
https://doi.org/10.1021/ja011285y
https://doi.org/10.1021/ja011285y
Autor:
Patrick Bernardelli, Leo A. Paquette
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3751344bb86f4f252056f6f0f89fdf8f
https://doi.org/10.1002/chin.199827124
https://doi.org/10.1002/chin.199827124