Poly(2-methyl-2-oxazoline) as a polyethylene glycol alternative for lipid nanoparticle formulation

Autor: Dwain George van Zyl, Livia Palmerston Mendes, Raphaela Patricia Semper, Christine Rueckert, Patrick Baumhof

Publikováno v: Frontiers in Drug Delivery, Vol 4 (2024)

Lipid nanoparticles (LNPs) have emerged as the platform of choice for mRNA delivery. Polyethylene glycol (PEG) is considered a key component of currently approved LNP-based delivery systems as it ensures particle stability and shapes various facets o

Externí odkaz: https://doaj.org/article/99d846eb124e4c83a9e760bdcd13012c

Proximity Ligation Assays for In Situ Detection of Innate Immune Activation: Focus on In Vitro-Transcribed mRNA

Autor: Emmeline L. Blanchard, Kristin H. Loomis, Sushma M. Bhosle, Daryll Vanover, Patrick Baumhof, Bruno Pitard, Chiara Zurla, Philip J. Santangelo

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 52-66 (2019)

The characterization of innate immune activation is crucial for vaccine and therapeutic development, including RNA-based vaccines, a promising approach. Current measurement methods quantify type I interferon and inflammatory cytokine production, but

Externí odkaz: https://doaj.org/article/ce9a7b51eb514c22a442138d2bda3bc5

Lipid nanoparticle delivery of unmodified mRNAs encoding multiple monoclonal antibodies targeting poxviruses in rabbits

Autor: Eric M. Mucker, Carolin Thiele-Suess, Patrick Baumhof, Jay W. Hooper

Publikováno v: Molecular therapy. Nucleic acids. 28

Poxviruses are a large and complex family of viruses with members such as monkeypox virus and variola virus. The possibility of an outbreak of monkeypox virus (or a related poxvirus) or the misuse of variola virus justifies the development of counter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b87ff3ecaecef9b7a28df3f4ad5908
https://pubmed.ncbi.nlm.nih.gov/35664703

Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

Autor: Philip J. Santangelo, Kevin E. Lindsay, Bruno Pitard, Chiara Zurla, Mariluz Araínga, Peng Xiao, Daryll Vanover, Jared Beyersdorf, Kenneth A. Rogers, Sushma M. Bhosle, Francois Villinger, Patrick Baumhof, Lisa Shirreff

Publikováno v: Nature Biomedical Engineering
Nature Biomedical Engineering, 2019, Epub ahead of print. ⟨10.1038/s41551-019-0378-3⟩
Nature Biomedical Engineering, Nature Publishing Group, 2019, Epub ahead of print. ⟨10.1038/s41551-019-0378-3⟩

These authors contributed equally : Kevin E. Lindsay, Sushma M. Bhosle and Chiara Zurla.; International audience; Visualization of the spatio-temporal trafficking of vaccines after their delivery would help evaluate the efficacy of candidate formulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9322a626e8768dd0744f0634b0c58e21
https://www.hal.inserm.fr/inserm-02089115

A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

Autor: Regina Heidenreich, Johannes Lutz, Karl-Josef Kallen, Edith Jasny, Mariola Fotin-Mleczek, Birgit Scheel, Aleksandra Kowalczyk, Jochen Probst, Söhnke Voss, Patrick Baumhof

Publikováno v: International Journal of Cancer. 137:372-384

Protein- and peptide-based tumor vaccines depend on strong adjuvants to induce potent immune responses. Here, we demonstrated that a recently developed novel adjuvant based on a non-coding, long-chain RNA molecule, termed RNAdjuvant(®) , profoundly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8008b617690e2cd7f1d3e3ca9f6902f7
https://doi.org/10.1002/ijc.29402