Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Patrick B. F. O'Connor"'
Autor:
Patrick B. F. O’Connor, Jennifer Mahony, Eoghan Casey, Pavel V. Baranov, Douwe van Sinderen, Martina M. Yordanova
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTBacteria have evolved diverse defense mechanisms to counter bacteriophage attacks. Genetic programs activated upon infection characterize phage–host molecular interactions and ultimately determine the outcome of the infection. In this study
Externí odkaz:
https://doaj.org/article/686b9e90ff334a5f9f68107dec1dc818
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Ribosome profiling data can suffer from uneven coverage which hampers estimation of elongation rates. Connor et al.present an enhanced data smoothing method for Ribo-seq data and highlight significant variability in sequence determinants of ribosome
Externí odkaz:
https://doaj.org/article/42f88ac9182b471484c206f16074bb5e
Autor:
Fabio Hedayioglu, Emma J Mead, Patrick B F O'Connor, Matas Skiotys, Owen J Sansom, Giovanna R Mallucci, Anne E Willis, Pavel V Baranov, C Mark Smales, Tobias von der Haar
Publikováno v:
Nucleic acids research. 50(19)
The assessment of transcriptome-wide ribosome binding to mRNAs is useful for studying the dynamic regulation of protein synthesis. Two methods frequently applied in eukaryotic cells that operate at different levels of resolution are polysome profilin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c543a1b2009c7dc150fcb7773317695
https://pubmed.ncbi.nlm.nih.gov/35979952
https://pubmed.ncbi.nlm.nih.gov/35979952
Autor:
Marina V. Serebryakova, Petr N. Datskevich, Audrey M. Michel, Ivan N. Shatsky, Maria S Mikhaylova, Patrick B F O'Connor, John F. Atkins, Pavel V. Baranov, Sergey I. Kovalchuk, Dmitri B. Papkovsky, Stephen J Kiniry, Gary Loughran, Dmitry E. Andreev, Alexander V. Zhdanov, Fedor N. Rozov
Publikováno v:
Proc Natl Acad Sci U S A
While near-cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588ae2cc10ead170e830116f502b577f
https://doi.org/10.1073/pnas.2001433117
https://doi.org/10.1073/pnas.2001433117
Autor:
Patrick B F O'Connor, Victor Koteliansky, Robert Langer, Timofei S. Zatsepin, Pavel V. Baranov, Daniel G. Anderson, Maxim V. Gerashchenko, Kevin J. Kauffman, Vadim N. Gladyshev, Anna S. Fefilova, Charles A. Whittaker, Elena M. Smekalova, Roman L. Bogorad
Publikováno v:
Elsevier
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
© 2019 Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3707e1b6cc7fc1075d06f75056c18207
https://doi.org/10.1016/j.omtn.2019.11.009
https://doi.org/10.1016/j.omtn.2019.11.009
Autor:
Alexander V. Zhdanov, John F. Atkins, Ivan N. Shatsky, Stephen J Kiniry, Petr N. Datskevich, Maria S Mikhaylova, Sergey I. Kovalchuk, Marina V. Serebryakova, Fedor N. Rozov, Audrey M. Michel, Pavel V. Baranov, Gary Loughran, Patrick B F O'Connor, Dmitri B. Papkovsky, Dmitry E. Andreev
While near cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (POLGmRNA initiates almost as efficiently (~60-70%) as an AUG in optimal context. This CUG directs translation of a conserved 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f8087d1789303bd57ce8e10c000e3e
Autor:
Sinéad O’Loughlin, Ekaterina Samatova, Patrick B F O'Connor, Pavel V. Baranov, Jonathan S. Weissman, Arthur Coakley, John F. Atkins, Gary Loughran, Joseph D. Puglisi, Marina V. Rodnina, Mariia Klimova, Norma M. Wills, Mark C. Capece
Publikováno v:
Journal of Molecular Biology
Efficient translational bypassing of a 50 nt non-coding gap in a phage T4 topoisomerase subunit gene (gp60) requires several recoding signals. Here we investigate the function of the mRNA stem loop 5′ of the take-off codon, as well as the importanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0157ebc30a9ae3ad95d0205f0ea88c
https://pubmed.ncbi.nlm.nih.gov/32454154
https://pubmed.ncbi.nlm.nih.gov/32454154
Autor:
Dmitri B. Papkovsky, Pavel V. Baranov, Maria S. Benitez-Cantos, Martina M. Yordanova, Dmitry E. Andreev, Patrick B F O'Connor, Alexander V. Zhdanov, Sergey I. Kovalchuk
Publikováno v:
Genome Res
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Eukaryotic translation initiation involves preinitiation ribosomal complex 5′ -to-3′ directional probing of mRNA for codons suitable for starting protein synthesis. The recognition of codons as starts depends on the codon identity and on its imme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa867b70124283509b4ae14c40fc4afd
http://hdl.handle.net/10481/64164
http://hdl.handle.net/10481/64164
Publikováno v:
Nucleic Acids Research
Ribosome profiling (Ribo-Seq) is a technique that allows for the isolation and sequencing of mRNA fragments protected from nuclease digestion by actively translating ribosomes. Mapping these ribosome footprints to a genome or transcriptome generates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc26c2954ba18eb226a180b11ab2064
https://doi.org/10.1093/nar/gky842
https://doi.org/10.1093/nar/gky842
Autor:
Dmitry E. Andreev, Stephen J Kiniry, Dmitry B Papkovsky, Ioanna Tzani, Patrick B F O'Connor, Marco Mariotti, Pavel V. Baranov, Audrey M. Michel, Gary Loughran, Martina M. Yordanova, John F. Atkins, Alexander V. Zhdanov, Paul Saffert, Vadim N. Gladyshev
Publikováno v:
Nature. 553:356-360
In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process1,2. Here we report a new mechanism that limits the number of complete protein molecules that can be synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac89dbfe27d5ca9554cae892b0178416
https://doi.org/10.1038/nature25174
https://doi.org/10.1038/nature25174