Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Patrick Arbuthnot"'
Autor:
Ridhwaanah Jacobs, Makafui Dennis Dogbey, Njabulo Mnyandu, Keila Neves, Stefan Barth, Patrick Arbuthnot, Mohube Betty Maepa
Publikováno v:
Microorganisms, Vol 11, Iss 12, p 2985 (2023)
Hepatitis B virus (HBV) has afflicted humankind for decades and there is still no treatment that can clear the infection. The development of recombinant adeno-associated virus (rAAV)-based gene therapy for HBV infection has become important in recent
Externí odkaz:
https://doaj.org/article/d0c6413a36ca492399e5c5715e39fed7
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Despite the five decades having passed since discovery of the hepatitis B virus (HBV), together with development of an effective anti-HBV vaccine, infection with the virus remains a serious public health problem and results in nearly 900,000
Externí odkaz:
https://doaj.org/article/f2cf3259d805455e928b726cf86a410b
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Synthetic mRNA technologies represent a versatile platform that can be used to develop advanced drug products. The remarkable speed with which vaccine development programs designed and manufactured safe and effective COVID-19 vaccines has rekindled i
Externí odkaz:
https://doaj.org/article/9611659b11c54e44835919cebf8a44d3
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1173 (2023)
Africa bears the highest burden of infectious diseases, yet the continent is heavily reliant on First World countries for the development and supply of life-saving vaccines. The COVID-19 pandemic was a stark reminder of Africa’s vaccine dependence
Externí odkaz:
https://doaj.org/article/f1c90a11467b4d3c9f95a435971553d5
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Infection with the hepatitis B virus (HBV) continues to pose a major threat to public health as approximately 292 million people worldwide are currently living with the chronic form of the disease, for which treatment is non-curative. Chronic HBV inf
Externí odkaz:
https://doaj.org/article/56edca2e3f8e47f08419130e896271cb
Autor:
Kristie Bloom, Haajira Kaldine, Toni Cathomen, Claudio Mussolino, Abdullah Ely, Patrick Arbuthnot
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Chronic infection with hepatitis B virus (HBV) is a serious global health problem. Persistence of the virus occurs as a result of stability of the replication intermediate comprising covalently closed circular DNA (cccDNA). Develo
Externí odkaz:
https://doaj.org/article/43d37d072faf498288f79ace82905387
Autor:
Mohube B. Maepa, Abdullah Ely, Anna Kramvis, Kristie Bloom, Kubendran Naidoo, Omphile E. Simani, Tongai G. Maponga, Patrick Arbuthnot
Publikováno v:
Viruses, Vol 14, Iss 9, p 1939 (2022)
Despite being vaccine-preventable, hepatitis B virus (HBV) infection remains the seventh leading cause of mortality in the world. In South Africa (SA), over 1.9 million people are chronically infected with HBV, and 70% of all Black chronic carriers a
Externí odkaz:
https://doaj.org/article/91f22b6109e547619a8d7f6aa172e00b
Publikováno v:
BioTechniques, Vol 66, Iss 1, Pp 37-39 (2019)
Generating mRNA in vitro to encode therapeutic or cell-modifying proteins is rapidly gaining favor. An important factor that determines efficiency of translation from in vitro transcribed mRNA is the length of the 3′ poly(A) sequence. However, repr
Externí odkaz:
https://doaj.org/article/7501ce258a854c109e6ebbe306e6d17c
Autor:
Shonisani Wendy Limani, Njabulo Mnyandu, Abdullah Ely, Reubina Wadee, Anna Kramvis, Patrick Arbuthnot, Mohube Betty Maepa
Publikováno v:
Viruses, Vol 13, Iss 11, p 2247 (2021)
The paucity of animal models that simulate the replication of the hepatitis B virus (HBV) is an impediment to advancing new anti-viral treatments. The work reported here employed recombinant adeno-associated viruses (AAVs) to model HBV subgenotype A1
Externí odkaz:
https://doaj.org/article/689e6cf075b94dd7a793c5b0db69c232
Autor:
Tiffany Smith, Prashika Singh, Kay Ole Chmielewski, Kristie Bloom, Toni Cathomen, Patrick Arbuthnot, Abdullah Ely
Publikováno v:
Viruses, Vol 13, Iss 7, p 1344 (2021)
Persistent hepatitis B virus (HBV) infection remains a serious medical problem worldwide, with an estimated global burden of 257 million carriers. Prophylactic and therapeutic interventions, in the form of a vaccine, immunomodulators, and nucleotide
Externí odkaz:
https://doaj.org/article/937c052fb6e244cdae041dbe15844907