Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Patrick Appiah-Kubi"'
Autor:
Aganze G. Mushebenge, Samuel C. Ugbaja, Sphamandla E. Mtambo, Thandokuhle Ntombela, Joy I. Metu, Oludotun Babayemi, Joy I. Chima, Patrick Appiah-Kubi, Adeshina I. Odugbemi, Mthobisi L. Ntuli, Rene Khan, Hezekiel M. Kumalo
Publikováno v:
Molecules, Vol 28, Iss 6, p 2641 (2023)
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19, which was declared a global pandemic in March 2020 by the World Health Organization (WHO). Since SARS-CoV-2 main protease plays an essential role in the vir
Externí odkaz:
https://doaj.org/article/18bf8222e4344f97b15aa0942eb9202d
Autor:
Samuel C. Ugbaja, Sphamandla E. Mtambo, Aganze G. Mushebenge, Patrick Appiah-Kubi, Bahijjahtu H. Abubakar, Mthobisi L. Ntuli, Hezekiel M. Kumalo
Publikováno v:
Molecules, Vol 27, Iss 14, p 4376 (2022)
The use of vaccinations and antiviral medications have gained popularity in the therapeutic management of avian influenza H7N9 virus lately. Antiviral medicines are more popular due to being readily available. The presence of the neuraminidase protei
Externí odkaz:
https://doaj.org/article/008841523859407f9f141ff849c5d582
Publikováno v:
Molecules, Vol 25, Iss 18, p 4239 (2020)
Covalent inhibition has recently gained a resurgence of interest in several drug discovery areas. The expansion of this approach is based on evidence elucidating the selectivity and potency of covalent inhibitors when bound to particular amino acids
Externí odkaz:
https://doaj.org/article/dcea6cc75b1c4af0afc855b08854f5fe
Autor:
Hezekiel M. Kumalo, Nelisiwe S. Gumede, Patrick Appiah-Kubi, Monsurat M. Lawal, Samuel C. Ugbaja
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:5253-5265
β-amyloid precursor protein cleaving enzyme1 (BACE1) has prominently been an important drug design target implicated in Alzheimer's disease pathway. The failure rate of most of the already tested drugs at different clinical phases remains a major co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db93c3c79dd7c055043d2d957ac7a7b6
https://doi.org/10.1080/07391102.2020.1869099
https://doi.org/10.1080/07391102.2020.1869099
Publikováno v:
Journal of Molecular Recognition. 34
More recently, there has been a paradigm shift toward selective drug targeting in the treatment of neurological disorders, including drug addiction, schizophrenia, and Parkinson's disease mediated by the different dopamine receptor subtypes. Antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d3ae3a180d645dc25ab2912f7fd66a
https://doi.org/10.1002/jmr.2885
https://doi.org/10.1002/jmr.2885
Publikováno v:
Medicinal Chemistry. 17
INTRODUCTION Blocking Human Immunodeficiency Virus type 1 (HIV-1) entry via C-C chemokine receptor 5 (CCR5) inhibition has remained an essential strategy in HIV drug discovery. This underlies the development of CCR5 blockers, such as Maraviroc, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935761662907ff6a8224579412b2123a
https://doi.org/10.2174/1573406417666201208122110
https://doi.org/10.2174/1573406417666201208122110
Publikováno v:
Journal of molecular recognition : JMRREFERENCES. 34(5)
More recently, there has been a paradigm shift toward selective drug targeting in the treatment of neurological disorders, including drug addiction, schizophrenia, and Parkinson's disease mediated by the different dopamine receptor subtypes. Antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bd80a340a33da86e984bbbe063f4a4f
https://pubmed.ncbi.nlm.nih.gov/33401335
https://pubmed.ncbi.nlm.nih.gov/33401335
The emergence of cloud computing has changed perception of all regarding software delivery, development models and infrastructure. Cloud computing has a potential of providing elastic, easily manageable, powerful and cost effective solutions. The rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db2774bfd020e8d50476cdb4153bf51
https://zenodo.org/record/4243308
https://zenodo.org/record/4243308
Publikováno v:
Molecular informaticsReferences. 38(11-12)
Dopamine receptors constitute a unique class of G-protein coupled receptors that mediate the activities of dopamine, a neurotransmitter implicated in diverse neurological diseases when dysregulated. Over the years, antipsychotic drugs have been prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95e8bddd99935af06c4d8bf56037803c
https://pubmed.ncbi.nlm.nih.gov/31433121
https://pubmed.ncbi.nlm.nih.gov/31433121
Publikováno v:
The protein journal. 38(2)
The constitutive BCR–ABL1 active protein fusion has been identified as the main cause of chronic myeloid leukemia. The emergence of T334I and D381N point mutations in BCR–ABL1 confer drug resistance. Recent experimental studies show a synergistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3841639793571a24b212900a4bb5b1
https://pubmed.ncbi.nlm.nih.gov/30877503
https://pubmed.ncbi.nlm.nih.gov/30877503