Zobrazeno 1 - 10
of 308
pro vyhledávání: '"Patrick Aebischer"'
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Abstract Background Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson’s disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to ne
Externí odkaz:
https://doaj.org/article/701c2634887a482ba26dc2d0ce8ba343
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 2675-2700 (2015)
Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the pathogenesis of Parkinson’s disease. While the normal function of alpha-synuclein is mainly related to the control of vesicular neurotransmission, its pathogenic
Externí odkaz:
https://doaj.org/article/3d7215ac97e745dbb88c11213dfec04a
Autor:
Karin Löw, Patrick Aebischer
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 2, Pp 189-201 (2012)
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. While sporadic in the majority of cases, PD-linked dominant mutations in the α-synuclein and LRRK-2 genes, and
Externí odkaz:
https://doaj.org/article/ff01dee9d808402587339dfa5f29c5bc
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 385-398 (2009)
We explored the relationship between ubiquitin proteasome system (UPS) and lysosomal markers and the formation of α-synuclein (α-syn) inclusions in nigral neurons in Parkinson disease (PD). Lysosome Associated Membrane Protein 1(LAMP1), Cathepsin D
Externí odkaz:
https://doaj.org/article/bf3d20edf888427bb99553cb6bcc75d6
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 1, Pp 32-41 (2009)
Loss of function of parkin, an ubiquitin ligase, is responsible for autosomal recessive juvenile parkinsonism (AR-JP). Parkin-associated endothelin receptor-like receptor (Pael-R) was identified as an authentic substrate of parkin and is thought to a
Externí odkaz:
https://doaj.org/article/84ce233a35bb4ffb909056e2c1189b60
Autor:
Ali Sajadi, Jean-Charles Bensadoun, Bernard L. Schneider, Christophe Lo Bianco, Patrick Aebischer
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 1, Pp 119-129 (2006)
Numerous studies have shown the neuroprotective and regenerative benefits of glial cell line-derived neurotrophic factor (GDNF) in animal models of PD. Brain delivery of GDNF can, however, be associated with limiting side-effects in both primates and
Externí odkaz:
https://doaj.org/article/4fbaa49b9d12491698e9e7cdd7d9ae3f
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 1, Pp 29-34 (2006)
Reactive oxygen species are considered to contribute to the pathogenesis of Parkinson's disease (PD). In order to study viral vector-mediated overexpression of the antioxidant enzyme glutathione peroxidase (GPX) as a potential neuroprotective approac
Externí odkaz:
https://doaj.org/article/0f39cf4c56464fbcb8690d0b9d0526b0
Autor:
Diana Zala, Alexandra Benchoua, Emmanuel Brouillet, Valérie Perrin, Marie-Claude Gaillard, Anne D. Zurn, Patrick Aebischer, Nicole Déglon
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 3, Pp 785-798 (2005)
A lentiviral vector expressing a mutant huntingtin protein (htt171-82Q) was used to generate a chronic model of Huntington's disease (HD) in rat primary striatal cultures. In this model, the majority of neurons expressed the transgene so that Western
Externí odkaz:
https://doaj.org/article/d3e563eb8d99412b957653a25b2294ea
Autor:
Haruhiko Kishima, Thomas Poyot, Jocelyne Bloch, Julien Dauguet, Françoise Condé, Frédéric Dollé, Françoise Hinnen, William Pralong, Stéphane Palfi, Nicole Déglon, Patrick Aebischer, Philippe Hantraye
Publikováno v:
Neurobiology of Disease, Vol 16, Iss 2, Pp 428-439 (2004)
Glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor with restorative effects in a variety of rodent and primate models of Parkinson's disease (PD), could be of therapeutic value to PD. In this study, we show that intraven
Externí odkaz:
https://doaj.org/article/d219e7e5402d4b57a1973a5e3ed5beb5
Publikováno v:
Neurobiology of Disease, Vol 16, Iss 1, Pp 139-149 (2004)
Approximately 2% of amyotrophic lateral sclerosis (ALS) cases are associated with mutations in the cytosolic Cu/Zn superoxide dismutase 1 (SOD1) gene. Transgenic SOD1 mice constitute useful models of ALS to screen therapeutical approaches. Glial cell
Externí odkaz:
https://doaj.org/article/ef5fe4cfeba2491ebc62880fd8e86070