Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Patrick A. Sandoz"'
Autor:
Patrick A. Sandoz, Kyra Kuhnigk, Edina K. Szabo, Sarah Thunberg, Elina Erikson, Niklas Sandström, Quentin Verron, Andreas Brech, Carsten Watzl, Arnika K. Wagner, Evren Alici, Karl-Johan Malmberg, Michael Uhlin, Björn Önfelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract γδ T cells play a pivotal role in protection against various types of infections and tumours, from early childhood on and throughout life. They consist of several subsets characterised by adaptive and innate-like functions, with Vγ9Vδ2 b
Externí odkaz:
https://doaj.org/article/4a2ebb7ba33b4497b45e14c4b00964b9
Autor:
Patrick A. Sandoz, Robin A. Denhardt-Eriksson, Laurence Abrami, Luciano A. Abriata, Gard Spreemann, Catherine Maclachlan, Sylvia Ho, Béatrice Kunz, Kathryn Hess, Graham Knott, Francisco S. Mesquita, Vassily Hatzimanikatis, F. Gisou van der Goot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by
Externí odkaz:
https://doaj.org/article/e2c0d4d357a547d2987d3099985f5053
Autor:
Rahul S. Kathayat, Yang Cao, Pablo D. Elvira, Patrick A. Sandoz, María-Eugenia Zaballa, Maya Z. Springer, Lauren E. Drake, Kay F. Macleod, F. Gisou van der Goot, Bryan C. Dickinson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
S-palmitoylation regulation has been studied mostly in the cytosol and its role in mitochondria is unclear. Here the authors develop fluorescent mitochondria-targeted probes and find that depalmitoylation occurs in mitochondria and it’s influenced
Externí odkaz:
https://doaj.org/article/bc4834262d94405eb36f3f27406abe02
Autor:
Laurence Abrami, Tiziano Dallavilla, Patrick A Sandoz, Mustafa Demir, Béatrice Kunz, Georgios Savoglidis, Vassily Hatzimanikatis, F Gisou van der Goot
Publikováno v:
eLife, Vol 6 (2017)
S-Palmitoylation is the only reversible post-translational lipid modification. Knowledge about the DHHC palmitoyltransferase family is still limited. Here we show that human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is control
Externí odkaz:
https://doaj.org/article/a3e6b2cca65a431ab5ba10545592a703
Autor:
Laurence Abrami, Martina Audagnotto, Francisco Mesquita, Matteo Dal Peraro, Muhammad U. Anwar, F. Gisou van der Goot, Sylvia Ho, Maria J. Marcaida, Florence Pojer, Giulia Fonti, Patrick A. Sandoz
Publikováno v:
Nature Chemical Biology. 17:438-447
Many biochemical reactions require controlled recruitment of proteins to membranes. This is largely regulated by posttranslational modifications. A frequent one is S-acylation, which consists of the addition of acyl chains and can be reversed by poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9addf8dc0f6db35fcd977cabc8c716
https://doi.org/10.1038/s41589-021-00753-2
https://doi.org/10.1038/s41589-021-00753-2
Autor:
Valentina Carannante, Niklas Sandström, Karl Olofsson, Shi Yong Neo, Patrick Albert Sandoz, Hanna Van Ooijen, Quentin Verron, Jacopo Fontana, Damien Toullec, Elisabeth Moussaud-Lamodière, Brinton Seashore-Ludlow, Thomas Frisk, Madoka Takai, Päivi Östling, Felix Haglund, Andreas Lundqvist, Martin Wiklund, Björn Önfelt
Publikováno v:
Cancer Research. 83:4578-4578
Tumor diversity and rarity of patient tumor material negatively contribute to the development of new effective treatments for sarcomas. As a high proportion of sarcoma patients presents inherent or acquired chemo-resistance, immune checkpoint inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1108aca84b3b5890cf391b0cb14612
https://doi.org/10.1158/1538-7445.am2023-4578
https://doi.org/10.1158/1538-7445.am2023-4578
Autor:
Niklas Sandström, Ludwig Brandt, Patrick A. Sandoz, Chiara Zambarda, Karolin Guldevall, Malte Schulz-Ruhtenberg, Bernd Rösener, Robin A. Krüger, Björn Önfelt
Publikováno v:
Lab on a chip. 22(11)
Miniaturization of cell culture substrates enables controlled analysis of living cells in confined micro-scale environments. This is particularly suitable for imaging individual cells over time, as they can be monitored without escaping the imaging f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c5e0af4bb3f9cb5a817d6c991a7872
https://pubmed.ncbi.nlm.nih.gov/35470832
https://pubmed.ncbi.nlm.nih.gov/35470832
Autor:
Niklas, Sandström, Valentina, Carannante, Karl, Olofsson, Patrick A, Sandoz, Elisabeth L, Moussaud-Lamodière, Brinton, Seashore-Ludlow, Hanna, Van Ooijen, Quentin, Verron, Thomas, Frisk, Madoka, Takai, Martin, Wiklund, Päivi, Östling, Björn, Önfelt
Publikováno v:
Cell reports methods. 2(7)
Here, we present a methodology based on multiplexed fluorescence screening of two- or three-dimensional cell cultures in a newly designed multichambered microwell chip, allowing direct assessment of drug or immune cell cytotoxic efficacy. We establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fc9a4ceaf67a8fe8692fe0aa5c6cd71
https://pubmed.ncbi.nlm.nih.gov/35880015
https://pubmed.ncbi.nlm.nih.gov/35880015
Autor:
F. G. van der Goot, Martina Audagnotto, Sylvia Ho, M. Anward, Laurence Abrami, Maria J. Marcaida, Florence Pojer, M. Dal Peraro, Giulia Fonti, Patrick A. Sandoz, Francisco Mesquita
Many biochemical reactions occur at the membrane interfaces. The proper control of these reactions requires spatially and temporally controlled recruitment of protein complexes. These assemblies are largely regulated by post-translational modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b14a6af6de54544e39e26fcdce16529
https://doi.org/10.1101/2020.06.18.157545
https://doi.org/10.1101/2020.06.18.157545
Autor:
Josefine, Dunst, Vassilis, Glaros, Lukas, Englmaier, Patrick A, Sandoz, Björn, Önfelt, Jan, Kisielow, Taras, Kreslavsky
Publikováno v:
Journal of Leukocyte Biology
Although γδTCRs were discovered more than 30 yr ago, principles of antigen recognition by these receptors remain unclear and the nature of these antigens is largely elusive. Numerous studies reported that T cell hybridomas expressing several Vγ1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cca4e7085668a10f2242d7bd965557bb
https://pubmed.ncbi.nlm.nih.gov/31943366
https://pubmed.ncbi.nlm.nih.gov/31943366