Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patrick A. Newbury"'
Autor:
Ke Liu, Patrick A. Newbury, Benjamin S. Glicksberg, William Z. D. Zeng, Shreya Paithankar, Eran R. Andrechek, Bin Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While cell lines and organoids are extensively used to study cancer, how closely they resemble the disease in patients remains unclear. Here, Liu et al. shed light on this issue by comparing the genomic and transcriptomic profiles of different breast
Externí odkaz:
https://doaj.org/article/7eb9424dafc04cdfaba1f2ce0b7d5375
Autor:
Rama Shankar, Mara L. Leimanis, Patrick A. Newbury, Ke Liu, Jing Xing, Derek Nedveck, Eric J. Kort, Jeremy W Prokop, Guoli Zhou, André S Bachmann, Bin Chen, Surender Rajasekaran
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103122- (2020)
Background: Multiple organ dysfunction syndrome (MODS) occurs in the setting of a variety of pathologies including infection and trauma. Some patients decompensate and require Veno-Arterial extra corporeal membrane oxygenation (ECMO) as a palliating
Externí odkaz:
https://doaj.org/article/c0e262db4eae409e8950a8dcfc7a34a8
Autor:
Evgenii Chekalin, Bin Chen, Kathleen A. Gallo, Patrick A. Newbury, Shreya Paithankar, Richard R. Neubig, Sean A. Misek, Andrea I. Doseff
Publikováno v:
Molecular Pharmacology. 101:1-12
Most B-Raf proto-oncogene (BRAF)-mutant melanoma tumors respond initially to BRAF inhibitor (BRAFi)/mitogen-activated protein kinase kinase 1 inhibitor (MEKi) therapy, although few patients have durable long-term responses to these agents. The goal o
Autor:
Patrick A. Newbury, William Z. D. Zeng, Benjamin S. Glicksberg, Bin Chen, Ke Liu, Eran R. Andrechek, Shreya Paithankar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Cell lines are widely-used models to study metastatic cancer although the extent to which they recapitulate the disease in patients remains unknown. The recent accumulation of genomic data provides an unprecedented opportunity to evaluate the utility
Autor:
Andrea I. Doseff, Patrick A. Newbury, Kathleen A. Gallo, Evgenii Chekalin, Bin Chen, Shreya Paithankar, Richard R. Neubig, Sean A. Misek
Most BRAF-mutant melanoma tumors respond initially to BRAFi/MEKi therapy, although few patients have durable long-term responses to these agents. The goal of this study was to utilize an unbiased computational approach to identify inhibitors which re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92322b960f5698e490149a95be64b26
Autor:
Guoli Zhou, Patrick A. Newbury, Rama Shankar, Mara Leimanis, Jeremy W. Prokop, Ke Liu, Derek Nedveck, Eric J. Kort, André S. Bachmann, Jing Xing, Bin Chen, Surender Rajasekaran
Publikováno v:
EBioMedicine, Vol 62, Iss, Pp 103122-(2020)
EBioMedicine
EBioMedicine
BackgroundMultiple organ dysfunction syndrome (MODS) occurs in the setting of a variety of pathologies including infection and trauma. Some of these patients will further decompensate and require extra corporeal membrane oxygenation (ECMO) as a palli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91609f8d83e12acf35961c67a79ec9af
Autor:
Benjamin S. Glicksberg, Billy Zeng, Evgeny Chekalin, Jing Xing, Caven Chow, Anita Wen, Bin Chen, Ke Liu, Patrick A. Newbury
Publikováno v:
Nat Protoc
As the field of precision medicine progresses, treatments for patients with cancer are starting to be tailored to their molecular as well as their clinical features. The emerging cancer subtypes defined by these molecular features require that dedica
Autor:
Patrick A. Newbury, Jing Xing, Anita Wen, Caven Chow, Billy Zeng, Ke Liu, Bin Chen, Benjamin S. Glicksberg
One approach to precision medicine is to discover drugs that target molecularly defined diseases. Voluminous cancer patient gene expression profiles have been accumulated in public databases, enabling the creation of a cancer-specific expression sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a424ef1c80da2d359075258a232421
https://doi.org/10.1101/821546
https://doi.org/10.1101/821546
Autor:
Alan T. Davis, Mitchell G. Eichhorn, John W. Polley, Patrick A. Newbury, Nicholas S Adams, John A. Girotto, Robert J. Mann
Publikováno v:
Plastic and Reconstructive Surgery. 139:1453-1457
BACKGROUND: Motorcycle helmet legislation has been a contentious topic for over a half-century. Benefits of helmet use in motorcycle trauma patients are well documented. In 2012, Michigan repealed its universal motorcycle helmet law in favor of a par
Publikováno v:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, vol 24, iss 2019
PSB
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, vol 24, iss 2019
PSB
The inconsistency of open pharmacogenomics datasets produced by different studies limits the usage of pharmacogenomics in biomarker discovery. Investigation of multiple pharmacogenomics datasets confirmed that the pairwise sensitivity data correlatio