Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Patrick A. Kiely"'
Autor:
Amira F. Mahdi, Joanne Nolan, Ruth Í. O’Connor, Aoife J. Lowery, Joanna M. Allardyce, Patrick A. Kiely, Kieran McGourty
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe extracellular matrix (ECM) has been heavily implicated in the development and progression of cancer. We have previously shown that Annexin A2 is integral in the migration and invasion of breast cancer cells and in the clinical progres
Externí odkaz:
https://doaj.org/article/8df755ab65fa48d3bd61e131535259df
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The histone H3 CENP-A is known to play a role during meiosis but its role in the testes in the fly is unknown. Here, the authors identify the mitochondrial metabolic protein complex ATP synthase F1 as interacting with CENP-A, promoting centromere coh
Externí odkaz:
https://doaj.org/article/fc77478783b448eba6143a43c99d1125
Autor:
Amira F. Mahdi, Beatrice Malacrida, Joanne Nolan, Mary E. McCumiskey, Anne B. Merrigan, Ashish Lal, Shona Tormey, Aoife J. Lowery, Kieran McGourty, Patrick A. Kiely
Publikováno v:
Cells, Vol 9, Iss 7, p 1582 (2020)
When breast cancer progresses to a metastatic stage, survival rates decline rapidly and it is considered incurable. Thus, deciphering the critical mechanisms of metastasis is of vital importance to develop new treatment options. We hypothesize that s
Externí odkaz:
https://doaj.org/article/fe9f9bc55c7740a4947120c8359f5614
Publikováno v:
F1000Research, Vol 5 (2016)
Quantitative real-time reverse-transcription polymerase chain reaction (RT-qPCR) remains the most sensitive technique for nucleic acid quantification. Its popularity is reflected in the remarkable number of publications reporting RT-qPCR data. Carefu
Externí odkaz:
https://doaj.org/article/f6bea07d8c444c5f96e971f04f398b8a
Autor:
Charlotte LM Krieckaert, Astrid van Tubergen, Johanna Elin Gehin, Borja Hernández-Breijo, Guillaume Le Mélédo, Alejandro Balsa, Peter Böhm, Sasa Cucnik, Ori Elkayam, Guro L Goll, Femke Hooijberg, Meghna Jani, Patrick DW Kiely, Neil McCarthy, Denis Mulleman, Victoria Navarro-Compán, Katherine Payne, Martin E Perry, Chamaida Plasencia-Rodriguez, Simon R Stones, Silje Watterdal Syversen, Annick de Vries, Katherine M Ward, Gertjan Wolbink, John D Isaacs
Publikováno v:
Annals of the Rheumatic Diseases, 82(1), 65-73. BMJ Publishing Group
Annals of the rheumatic diseases, 82(1), 65-73. BMJ Publishing Group
Krieckaert, C L M, van Tubergen, A, Gehin, J E, Hernández-Breijo, B, le Mélédo, G, Balsa, A, Böhm, P, Cucnik, S, Elkayam, O, Goll, G L, Hooijberg, F, Jani, M, Kiely, P D W, McCarthy, N, Mulleman, D, Navarro-Compán, V, Payne, K, Perry, M E, Plasencia-Rodriguez, C, Stones, S R, Syversen, S W, de Vries, A, Ward, K M, Wolbink, G & Isaacs, J D 2022, ' EULAR points to consider for therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases ', Annals of the Rheumatic Diseases, vol. 82, no. 1, pp. 65-73 . https://doi.org/10.1136/annrheumdis-2022-222155
Annals of the rheumatic diseases, 82(1), 65-73. BMJ Publishing Group
Krieckaert, C L M, van Tubergen, A, Gehin, J E, Hernández-Breijo, B, le Mélédo, G, Balsa, A, Böhm, P, Cucnik, S, Elkayam, O, Goll, G L, Hooijberg, F, Jani, M, Kiely, P D W, McCarthy, N, Mulleman, D, Navarro-Compán, V, Payne, K, Perry, M E, Plasencia-Rodriguez, C, Stones, S R, Syversen, S W, de Vries, A, Ward, K M, Wolbink, G & Isaacs, J D 2022, ' EULAR points to consider for therapeutic drug monitoring of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases ', Annals of the Rheumatic Diseases, vol. 82, no. 1, pp. 65-73 . https://doi.org/10.1136/annrheumdis-2022-222155
ObjectiveTo develop EULAR points-to-consider for therapeutic drug monitoring (TDM) of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases (RMDs).MethodsThe points-to-consider were developed in accordance with EULAR standardised
Autor:
Monica Casey, Feargal Twomey, Firinna Beattie McKenna, Dervla Kelly, Liam G. Glynn, Patrick A. Kiely, Des Leddin, Norma Bargary, Miriam McCarthy
Publikováno v:
Health Policy. 125:1482-1488
Background The University of Limerick Cancer network (ULCaN) was established in 2019 with funding from the Health Research Institute at the University of Limerick in order to build a network between individuals in academia, primary and secondary care
Publikováno v:
Patient Education and Counseling. 104:1347-1355
Objective We systematically reviewed the experiences of parents who have a child with adolescent idiopathic scoliosis in order to understand their needs and concerns related to their child’s healthcare, and assist health professionals in supporting
Publikováno v:
Biochemical and Biophysical Research Communications. 534:14-20
Bone represents the most common site for breast cancer metastasis. Bone is a highly dynamic organ that is constantly adapting to its biophysical environment, orchestrated largely by the resident osteocyte network. Osteocytes subjected to physiologica
Publikováno v:
Journal of Hospital Infection. 106:522-535
peer-reviewed Breast cancer is the second most prevalent form of cancer in women worldwide, with surgery remaining the standard treatment. The adverse impact of the surgery remains controversial. It has been suggested that systemic factors during the
Autor:
Helen Walden, Ruaidhrí J. Carmody, Domenico Somma, Matti Lepistö, Karen Keeshan, Christian Tyrchan, Patrick A. Kiely, Jennifer P. Mitchell, Izaskun Mitxitorena, Emma L. Smith
Publikováno v:
The Journal of Biological Chemistry
The transcription factor NF-ĸB is a master regulator of the innate immune response and plays a central role in inflammatory diseases by mediating the expression of pro-inflammatory cytokines. Ubiquitination-triggered proteasomal degradation of DNA-b