Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Patrick A. J. Haslett"'
Autor:
Lucas D. Ward, Ho-Chou Tu, Chelsea B. Quenneville, Shira Tsour, Alexander O. Flynn-Carroll, Margaret M. Parker, Aimee M. Deaton, Patrick A. J. Haslett, Luca A. Lotta, Niek Verweij, Manuel A. R. Ferreira, Regeneron Genetics Center, Geisinger-Regeneron DiscovEHR Collaboration, Aris Baras, Gregory Hinkle, Paul Nioi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Circulating liver enzymes, like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are highly heritable and predictive of disease. Here, the authors perform a genome-wide association study on ALT and AST, revealing a rare variant in
Externí odkaz:
https://doaj.org/article/f13505aebcc04860b9176de8ff12e468
Autor:
Paul Barber, Patrick A. J. Haslett, David H. Shepp, Upal Roy, Barbara Sherry, Helena Schmidtmayerova, Jonathan Abshier, Prashant Malhotra
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
The chemokine (C-C motif) chemokine ligand 18 (CCL18) is a structural homolog of CCL3 primarily produced by monocyte-derived cells with an M2 phenotype. Elevated levels of CCL18 have been observed in several diseases associated with malignancies and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cef83ad5a4d4262a3f3770c285ac70
http://link.springer.com/article/10.1038/s41598-019-41588-1
http://link.springer.com/article/10.1038/s41598-019-41588-1
Autor:
Patrick A. J. Haslett, Kyle R. Rudser, Kathleen A. Delaney, Robin Rumsey, Chester B. Whitley, Andrew Wey, Igor Nestrasil, Alia Ahmed, Elsa Shapiro, Michael Potegal
Publikováno v:
Molecular Genetics and Metabolism. 114:594-598
The Sanfilippo Behavior Rating Scale (SBRS), a 68 item questionnaire, has been developed to assess the behavioral phenotype of children with Sanfilippo syndrome and its progression over time. Fifteen scales rate orality, movement/activity, attention/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9642f41c40d344d68d102e7d876638
https://doi.org/10.1016/j.ymgme.2015.02.008
https://doi.org/10.1016/j.ymgme.2015.02.008
Autor:
Hans M. L. Spiegel, Henry Pollack, Simon Monard, William Borkowsky, Geraldine M. Gillespie, Elizabeth DeFalcon, Megan E. Sheehy, Andrew J. McMichael, Douglas F. Nixon, Sean M. Donahoe, Patrick A. J. Haslett, Graham S. Ogg
CD4+T cells are thought to be critical in the maintenance of virus-specific CD8+cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in HIV-1-specific CTL as the CD4+T-cell count decreases ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a6955e03d8ff375b09c049fa8e6936
https://doi.org/10.1128/jvi.74.2.1018-1022.2000
https://doi.org/10.1128/jvi.74.2.1018-1022.2000
Autor:
Ann J. Barbier, Patrick A. J. Haslett, Frits A. Wijburg, Jou-Ku Chung, Fiona Heap, Evelien Tump, Jan Pieter Marchal, Catherine Breen, Luying Pan, Stewart Rust, Nitin Nair, Jessica de Ruijter, Yongchang Qiu, Simon Jones
Publikováno v:
Molecular genetics and metabolism, 118(3), 198-205. Academic Press Inc.
Objective This was an open-label, phase 1/2 dose-escalation, safety trial of intrathecal recombinant human heparan -N- sulfatase (rhHNS) administered via intrathecal drug delivery device (IDDD) for treating mucopolysaccharidosis IIIA (NCT01155778). S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9849d491b6b11652b09544ca897f19e
https://pubmed.ncbi.nlm.nih.gov/27211612
https://pubmed.ncbi.nlm.nih.gov/27211612
Autor:
Yongchang Qiu, Thomas McCauley, John R Moriarity, Kendall D. Powell, Patrick A. J. Haslett, Hicham Naimy, Ann J. Barbier, Jiang Wu
Publikováno v:
Bioanalysis. 8(4)
Aims: Heparan sulfate (HS) accumulates in the central nervous system in mucopolysaccharidosis III type A (MPS IIIA). A validated LC–MS/MS assay was developed to measure HS in human cerebrospinal fluid (CSF). Methods & results: HS was extracted and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f187c38a1cb5bec4bbdf46560fb697df
https://pubmed.ncbi.nlm.nih.gov/26847798
https://pubmed.ncbi.nlm.nih.gov/26847798
Autor:
Jane Tomimori, Esper G. Kallas, Douglas F. Nixon, Karina I. Carvalho, Patrick A. J. Haslett, Solange M. Maeda, Marília Brasil Xavier, Fernanda R. Bruno, Jennifer E. Snyder-Cappione
Publikováno v:
Immunology. 136:96-102
Natural killer T (NKT) cells are a heterogeneous population of lymphocytes that recognize antigens presented by CD1d and have attracted attention because of their potential role linking innate and adaptive immune responses. Peripheral NKT cells displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc4388da23eb9f42ebbe44c18918304a
https://doi.org/10.1111/j.1365-2567.2012.03563.x
https://doi.org/10.1111/j.1365-2567.2012.03563.x
Autor:
David Alexanderian, Karl Eugen Mengel, Maureen Cleary, Elsa Shapiro, David A.H. Whiteman, Patrick A. J. Haslett, Paul Harmatz, Igor Nestrasil, Chester B. Whitley
Publikováno v:
The Journal of Pediatrics. 197:198-206.e2
To evaluate the natural course of disease progression in patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB), identify potential end points for future therapy trials, and characterize biomarkers related to the disease.A prospec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0a2d3cd19c8e9799a196d2c4b47719
https://doi.org/10.1016/j.jpeds.2018.01.044
https://doi.org/10.1016/j.jpeds.2018.01.044
Autor:
Kristopher L. Arheart, Rajendra Pahwa, Huanliang Liu, Savita Pahwa, Aida Chaparro, Seema Desai, Patrick A. J. Haslett, Gwendolyn B. Scott
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 45:501-507
BACKGROUND Defects of plasmacytoid (p) and myeloid (m) dendritic cells (DCs) occur in HIV infection. The aim of this study was to evaluate the maturation and function of DCs in children with perinatal HIV infection who were on antiretroviral therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28400fcb4a347ee0d666e64988af1f89
https://doi.org/10.1097/qai.0b013e3180654811
https://doi.org/10.1097/qai.0b013e3180654811
Autor:
James A. Ida, Savita Pahwa, Patrick A. J. Haslett, Seema Desai, Niraj Shrestha, Willem A. Hanekom
Publikováno v:
Journal of Immunological Methods. 310:86-99
We report a practical technique to assess peripheral blood dendritic cell (DC) maturation and function in whole blood (WB), which requires minimal blood volumes and minimizes ex vivo manipulations of clinical specimens. We determined optimal conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284295cef029665b6186eea5df3bc5a9
https://doi.org/10.1016/j.jim.2005.12.008
https://doi.org/10.1016/j.jim.2005.12.008