Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Patrick A. Forcelli"'
Autor:
Eric Witherspoon, Nicholas Zuczek, Gabrielle Williams, Briana Bernstein, Anjik Ghosh, Marko Culjat, Suhasini Kaushal, Patrick A. Forcelli
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionExposure to a range of anti-seizure medications (ASMs) during early brain development adversely impacts neurodevelopmental outcomes in both animal models and in clinical studies. Many ASMs, including phenobarbital, phenytoin, valproate (V
Externí odkaz:
https://doaj.org/article/9959f71ca64c463db4add9fe3d231bb9
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Phenobarbital (PB) and levetiracetam (LEV) are the first-line therapies for neonates with diagnosed seizures, however, a growing body of evidence shows that these drugs given during critical developmental windows trigger lasting molecul
Externí odkaz:
https://doaj.org/article/05538bee19844006bb4de70c82a9a498
Autor:
Irene Sanchez-Brualla, Anjik Ghosh, Viktoriya A. Gibatova, Sean Quinlan, Eric Witherspoon, Stefano Vicini, Patrick A. Forcelli
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionNeonatal hypoxia is a common cause of early-life seizures. Both hypoxia-induced seizures (HS), and the drugs used to treat them (e.g., phenobarbital, PB), have been reported to have long-lasting impacts on brain development. For example,
Externí odkaz:
https://doaj.org/article/d5dd8f24a3a2482bbf43e175406c6a61
Autor:
Holly T. Korthas, Bevan S. Main, Alex C. Harvey, Ruchelle G. Buenaventura, Evan Wicker, Patrick A. Forcelli, Mark P. Burns
Publikováno v:
Biology, Vol 11, Iss 7, p 1031 (2022)
Traumatic brain injury (TBI) is a significant risk factor for the development of sleep and circadian rhythm impairments. In this study we compare the circadian rhythms and sleep patterns in the high-frequency head impact (HFHI) and controlled cortica
Externí odkaz:
https://doaj.org/article/987c63714e934e91b974e82c26918d11
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
The deep and intermediate layers of the superior colliculus (DLSC) respond to visual, auditory, and tactile inputs and act as a multimodal sensory association area. In turn, activity in the DLSC can drive orienting and avoidance responses—such as s
Externí odkaz:
https://doaj.org/article/f5b2b8683cf34e1d840fc028a214b6fb
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
Cannabinoid (CB) receptor agonists are of growing interest as targets for anti-seizure therapies. Here we examined the effect of systemic administration of the CB receptor agonist WIN 55,212-2 (WIN) against audiogenic seizures (AGSs) in the Genetical
Externí odkaz:
https://doaj.org/article/722b78c4e21d4b878dc04ef44480ce42
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 87-87 (2022)
OBJECTIVES/GOALS: While anti-seizure medications are effective, nearly one third of patients have seizures that go untreated. Prior studies using evoked seizure models have shown that activation of the Superior Colliculus (SC) display anti-seizure ef
Externí odkaz:
https://doaj.org/article/9b6faf1ed9ba42c8956238386d7ae1fe
Autor:
Yichien Lee, Olga C. Rodriguez, Chris Albanese, Victor Rodrigues Santos, José Antônio Cortes de Oliveira, Ana Luiza Ferreira Donatti, Artur Fernandes, Norberto Garcia-Cairasco, Prosper N'Gouemo, Patrick A. Forcelli
Publikováno v:
Neurobiology of Disease, Vol 111, Iss , Pp 80-90 (2018)
Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat, mouse, and hamster. Two models that have been particularly well studied are the genetically ep
Externí odkaz:
https://doaj.org/article/1f529bfae11e46aeaaa5322ba326e875
Publikováno v:
Neurobiology of Disease, Vol 87, Iss , Pp 102-115 (2016)
Because sites of seizure origin may be unknown or multifocal, identifying targets from which activation can suppress seizures originating in diverse networks is essential. We evaluated the ability of optogenetic activation of the deep/intermediate la
Externí odkaz:
https://doaj.org/article/e002e86c8f424a4c9183dd55a04ee31e
Publikováno v:
Frontiers in Neural Circuits, Vol 12 (2018)
Neuropsychological and neuroimaging studies have suggested the presence of a fast, subcortical route for the processing of emotionally-salient visual information in the primate brain. This putative pathway consists of the superior colliculus (SC), pu
Externí odkaz:
https://doaj.org/article/86395e0d3b624603bd7f37578c137b99