Zobrazeno 1 - 10
of 519
pro vyhledávání: '"Patrick A. Duffy"'
Autor:
Camila H. Coelho, Susanna Marquez, Bergeline C. Nguemwo Tentokam, Anne D. Berhe, Kazutoyo Miura, Vishal N. Rao, Carole A. Long, Ogobara K. Doumbo, Issaka Sagara, Sara Healy, Steven H. Kleinstein, Patrick E. Duffy
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-7 (2024)
Abstract The impact of adjuvants on malaria vaccine-induced antibody repertoire is poorly understood. Here, we characterize the impact of two adjuvants, Alhydrogel® and AS01, on antibody clonotype diversity, binding and function, post malaria vaccin
Externí odkaz:
https://doaj.org/article/8c0cc61ee491450e8fc4e1ebcb75ad6e
Autor:
Oumar Attaher, Bruce Swihart, Lauren Dang, Gaoussou Santara, Almahamoudou Mahamar, Sekouba Keita, Adama Dembele, Bacary Soumana Diarra, Djibrilla Issiaka, Amadou Barry, Youssoufa Sidibé, Yahia T. Dicko, Seydou Traore, Fanta Koita, Ouelematou Ndiaye, Alassane Dicko, Jonathan D. Kurtis, Patrick E. Duffy, Michal Fried
Publikováno v:
International Journal of Infectious Diseases, Vol 139, Iss , Pp 171-175 (2024)
Objectives: The association between thrombocytopenia and parasite density or disease severity is described in numerous studies. In recent years, several studies described the protective role of platelets in directly killing Plasmodium parasites, medi
Externí odkaz:
https://doaj.org/article/8f730eeded8e4faf82341d362548ad96
Autor:
Puthupparampil V. Scaria, Nicole Roth, Kim Schwendt, Olga V. Muratova, Nada Alani, Lynn E. Lambert, Emma K. Barnafo, Christopher G. Rowe, Irfan U. Zaidi, Kelly M. Rausch, David L. Narum, Benjamin Petsch, Patrick E. Duffy
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract Malaria transmission-blocking vaccines (TBV) are designed to inhibit the sexual stage development of the parasite in the mosquito host and can play a significant role in achieving the goal of malaria elimination. Preclinical and clinical stu
Externí odkaz:
https://doaj.org/article/c1b01465fd85446dbc27c45b0c566753
Autor:
Niharika Shukla, Wai Kwan Tang, Camila H. Coelho, Carole A. Long, Sara A. Healy, Issaka Sagara, Kazutoyo Miura, Patrick E. Duffy, Niraj H. Tolia
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate transmission-blocking activity and induction of rapidly decreasing antibody titers in clinical trials. A comprehensive definition of all transmission-r
Externí odkaz:
https://doaj.org/article/2b2a9cc4c3a14a22b8a2355e8bb81d9f
Autor:
Almahamoudou Mahamar, Moussa Traore, Bruce Swihart, Oumar Attaher, Bacary Soumana Diarra, Gaoussou Santara, Djibrilla Issiaka, Amadou Barry, Youssoufa Sidibé, Yahia T. Dicko, Sekouba Keita, Oulematou Ndiaye, Alassane Dicko, Patrick E. Duffy, Michal Fried
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
In malaria-endemic areas, pregnant women are more susceptible to Plasmodium falciparum infection, especially primigravidae. During pregnancy, parasites sequester in the placenta and bind to the receptor chondroitin sulfate (CSA). This unique adhesion
Externí odkaz:
https://doaj.org/article/6bba23c0d0a24da6bfe4c146e79a5039
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011503 (2024)
[This corrects the article DOI: 10.1371/journal.ppat.1011370.].
Externí odkaz:
https://doaj.org/article/2fd3c47fdaa14deea346a6095f3de0cd
Autor:
Nicholas J. MacDonald, Kavita Singh, Karine Reiter, Vu Nguyen, Richard Shimp, Apostolos G. Gittis, Beth Chen, Martin Burkhardt, Baoshan Zhang, Zhixiong Wang, Raul Herrera, Mackenzie Moler, Duck-Yeon Lee, Sachy Orr-Gonzalez, Jessica Herrod, Lynn E. Lambert, Kelly M. Rausch, Olga Muratova, David S. Jones, Yimin Wu, Albert J. Jin, David N. Garboczi, Patrick E. Duffy, David L. Narum
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Development of a malaria vaccine that blocks transmission of different parasite stages to humans and mosquitoes is considered critical for elimination efforts. A vaccine using Pfs25, a protein on the surface of zygotes and ookinetes, is unde
Externí odkaz:
https://doaj.org/article/744dd43cb85546b1a8f8ee76086ef8c5
Autor:
Benjamin J. Krajacich, Djibril Samaké, Adama Dao, Moussa Diallo, Zana Lamissa Sanogo, Alpha Seydou Yaro, Amatigue Zeguime, Josué Poudiougo, Kadiatou Cissé, Mamadou Traoré, Alassane dit Assitoun, Roy Faiman, Irfan Zaidi, John Woodford, Patrick E. Duffy, Tovi Lehmann
Publikováno v:
Frontiers in Epidemiology, Vol 3 (2023)
BackgroundThe spread of SARS-CoV-2 cannot be well monitored and understood in areas without capacity for effective disease surveillance. Countries with a young population will have disproportionately large numbers of asymptomatic or pauci-symptomatic
Externí odkaz:
https://doaj.org/article/db6af8233cf34b83a868310084e65c5c
Autor:
Thomas L. Richie, L.W. Preston Church, Tooba Murshedkar, Peter F. Billingsley, Eric R. James, Mei-Chun Chen, Yonas Abebe, Natasha KC, Sumana Chakravarty, David Dolberg, Sara A. Healy, Halimatou Diawara, Mahamadou S. Sissoko, Issaka Sagara, David M. Cook, Judith E. Epstein, Benjamin Mordmüller, Melissa Kapulu, Andrea Kreidenweiss, Blandine Franke-Fayard, Selidji T. Agnandji, María-Silvia A. López Mikue, Matthew B.B. McCall, Laura Steinhardt, Martina Oneko, Ally Olotu, Ashley M. Vaughan, James G. Kublin, Sean C. Murphy, Said Jongo, Marcel Tanner, Sodiomon B. Sirima, Matthew B. Laurens, Claudia Daubenberger, Joana C. Silva, Kirsten E. Lyke, Chris J. Janse, Meta Roestenberg, Robert W. Sauerwein, Salim Abdulla, Alassane Dicko, Stefan H. I. Kappe, B. Kim Lee Sim, Patrick E. Duffy, Peter G. Kremsner, Stephen L. Hoffman
Publikováno v:
Expert Review of Vaccines, Vol 0, Iss 0 (2023)
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especi
Externí odkaz:
https://doaj.org/article/64ccc130995e4fbda0570808ef7ca47d
Autor:
Thayne H. Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D. Salinas, Jen C. C. Hume, Lynn E. Lambert, Patrick E. Duffy, Niraj H. Tolia
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract A malaria vaccine that blocks parasite transmission from human to mosquito would be a powerful method of disrupting the parasite lifecycle and reducing the incidence of disease in humans. Pfs48/45 is a promising antigen in development as a t
Externí odkaz:
https://doaj.org/article/08492bc9918f41c297b57ea2d425e412