Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Patrick A Zweidler-McKay"'
Publikováno v:
Frontiers in Pediatrics, Vol 2 (2014)
Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a pote
Externí odkaz:
https://doaj.org/article/f7b32a6ceda64284a7bfb80c1f0d6afb
Autor:
Shao-Qing Kuang, Zhihong Fang, Patrick A Zweidler-McKay, Hui Yang, Yue Wei, Emilio A Gonzalez-Cervantes, Yanis Boumber, Guillermo Garcia-Manero
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61807 (2013)
The Notch pathway can have both oncogenic and tumor suppressor roles, depending on cell context. For example, Notch signaling promotes T cell differentiation and is leukemogenic in T cells, whereas it inhibits early B cell differentiation and acts as
Externí odkaz:
https://doaj.org/article/32f37ae248ca49e686026301f9d49016
Autor:
Juliana Benito, Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Boehm, Hongbo Lu, Sergej Konoplev, Wendy Fang, Patrick A Zweidler-McKay, Dario Campana, Gautam Borthakur, Carlos Bueso-Ramos, Elizabeth Shpall, Deborah A Thomas, Craig T Jordan, Hagop Kantarjian, William R Wilson, Richard Lock, Michael Andreeff, Marina Konopleva
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23108 (2011)
Recent studies indicate that interactions between leukemia cells and the bone marrow (BM) microenvironment promote leukemia cell survival and confer resistance to anti-leukemic drugs. There is evidence that BM microenvironment contains hypoxic areas
Externí odkaz:
https://doaj.org/article/8a8e56495e7d49b3a2d1a39503f27346
Autor:
Sankaranarayan Kannan, Mary E. Irwin, Shelley M. Herbrich, Tiewei Cheng, LaNisha L. Patterson, Marisa J. L. Aitken, Kapil Bhalla, M. James You, Marina Konopleva, Patrick A. Zweidler-McKay, Joya Chandra
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 717 (2022)
Acute myeloid leukemia (AML) is a molecularly heterogenous hematological malignancy, with one of the most common mutations being internal tandem duplication (ITD) of the juxtamembrane domain of the fms-like tyrosine kinase receptor-3 (FLT3). Despite
Externí odkaz:
https://doaj.org/article/83896798bb5e4678bb764333446a8a57
Autor:
Naval Daver, Pau Montesinos, Ahmed Aribi, Giovanni Marconi, Jessica K. Altman, Eunice S. Wang, Gail J. Roboz, Patrick W. Burke, Gianluca Gaidano, Roland B. Walter, Xavier Thomas, Deepa Jeyakumar, Daniel J. DeAngelo, Harry P. Erba, Elisabetta Todisco, Kebede H. Begna, Anjali Advani, Lauris Gastaud, Adolfo De La Fuente, Antonio Curti, Lourdes M. Mendez, Paresh Vyas, Nicolas Boissel, Norbert Vey, Christian Recher, Thomas Longval, Uwe Platzbecker, Silke Kapp-Schwoerer, Christoph Schliemann, Marina Konopleva, Laura Torres, David A. Sallman, Guido Marcucci, Naveen Pemmaraju, Giovanni Martinelli, Hagop Kantarjian, Callum M Sloss, Kara E Malcolm, Patrick A Zweidler-McKay, Kendra Sweet
Publikováno v:
Blood. 140:145-149
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541eee0af57f5bce76f55a5d872f0c4e
https://doi.org/10.1182/blood-2022-158030
https://doi.org/10.1182/blood-2022-158030
Autor:
Michael J. Burke, Wanda L. Salzer, Meenakshi Devidas, Yunfeng Dai, Lia Gore, Joanne M. Hilden, Eric Larsen, Karen R. Rabin, Patrick A. Zweidler-McKay, Michael J. Borowitz, Brent Wood, Nyla A. Heerema, Andrew J. Carroll, Naomi Winick, William L. Carroll, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
With modern chemotherapy, approximately 90% of patients with pediatric acute lymphoblastic leukemia are now cured. However, subsets of patients can be identified who remain at very high risk of relapse with expected 4-year disease-free survival rates
Externí odkaz:
https://doaj.org/article/400df5614bb0423c96a66827ab493ef8
Autor:
Evgeniya Angelova, Charlene Audette, Yelena Kovtun, Naval Daver, Sa A. Wang, Sherry Pierce, Sergej N. Konoplev, Haitham Khogeer, Jeffrey L. Jorgensen, Marina Konopleva, Patrick A. Zweidler-McKay, L. Jeffrey Medeiros, Hagop M. Kantarjian, Elias J. Jabbour, Joseph D. Khoury
Publikováno v:
Haematologica, Vol 104, Iss 4 (2019)
The potential of CD123-targeted therapies in acute lymphoblastic leukemia/lymphoma remains largely unexplored. We examined CD123 expression levels in a large cohort of patients with acute lymphoblastic leukemia/lymphoma and assessed the in vitro impa
Externí odkaz:
https://doaj.org/article/06f028d2f45b400fa072b97577ee8cd0
Autor:
Patrick A. Zweidler-McKay, Joya Chandra, Charles G. Mullighan, Marina Konopleva, Guangchun Song, Jared K. Burks, Duncan H. Mak, Mandy G. Hall, Leonard S. Golfman, Shelley M. Herbrich, Marisa J.L. Aitken, Sankaranarayanan Kannan
(A) Representative histograms of Annexin V abundance in Ph-like B-ALL patient samples cultured with pate-bound IgG-Fc and and increasing concentrations of DLL1-Fc after 3 days. (B) mRNA expression of Notch target gene HES1 in T-ALL and B-ALL cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0566aa7777ad997647f911e9db4b48b2
https://doi.org/10.1158/1535-7163.22506076.v1
https://doi.org/10.1158/1535-7163.22506076.v1
Autor:
Ari Melnick, Iannis Aifantis, Weimin Ci, Olivier Elemento, Ivan Maillard, Patrick A. Zweidler-McKay, John P. Leonard, Kamala Bhatt, Wayne Tam, Zhuoning Li, Eric Perkey, Xabier Agirre, Katerina Hatzi, Yanwen Jiang, Camille W. Graham, Erin Oswald, Shao Ning Yang, Philmo Oh, Leandro Cerchietti, Martín Rivas, Mariano Cardenas, Ling Wang, Huimin Geng, Camille Lobry, Ester Valls
Supplementary Table S8. DLBCL p-values and rho values on GCB-DLBCL probesets for Notch2 pathway genes. (See Supplementary Figure S1G).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42efdd16395832aa1cd1f8e5ff4b8110
https://doi.org/10.1158/2159-8290.22532026.v1
https://doi.org/10.1158/2159-8290.22532026.v1
Autor:
Ari Melnick, Iannis Aifantis, Weimin Ci, Olivier Elemento, Ivan Maillard, Patrick A. Zweidler-McKay, John P. Leonard, Kamala Bhatt, Wayne Tam, Zhuoning Li, Eric Perkey, Xabier Agirre, Katerina Hatzi, Yanwen Jiang, Camille W. Graham, Erin Oswald, Shao Ning Yang, Philmo Oh, Leandro Cerchietti, Martín Rivas, Mariano Cardenas, Ling Wang, Huimin Geng, Camille Lobry, Ester Valls
Supplementary Figure S1. BCL6 displays a specific genomic localization pattern in FL. Supplementary Figure S2. Inverse correlation between BCL6 and NOTCH2 complex genes in primary GC B-cells. Supplementary Figure S3. GC reaction is impaired in Notch2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a421adc5484b4841a2793ce3d9f32c
https://doi.org/10.1158/2159-8290.22532050
https://doi.org/10.1158/2159-8290.22532050