Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Patrick A Paez"'
Autor:
Elizabeth Repasky, Harry D Bear, Fang Yuan, Xiaofei Yu, Wenjie Liu, Shixian Chen, Xueqian Cheng, Patrick A Paez, Tuanwei Sun, Chunyan Wei, Joseph W Landry, Andrew S Poklepovic, John R Subjeck, Chunqing Guo, Xiang-Yang Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background The efficacy of cancer immunotherapy can be limited by the poor immunogenicity of cancer and the immunosuppressive tumor microenvironment (TME). Immunologically programming the TME and creating an immune-inflamed tumor phenotype is critica
Externí odkaz:
https://doaj.org/article/8f4a5899c7754e49ab4f859993919521
Autor:
James A. Williams, Patrick A. Paez
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 494-503 (2023)
The cell and gene therapy industry has employed the same plasmid technology for decades in vaccination, cell and gene therapy, and as a raw material in viral vector and RNA production. While canonical plasmids contain antibiotic resistance markers in
Externí odkaz:
https://doaj.org/article/328a004e2bb244c38b6637ccf2167d91
Autor:
Heather L. Caslin, Brian O. Barnstein, Charles E. Chalfant, Neha Pondicherry, Daniel Abebayehu, L. Alexis Hoeferlin, Patrick A Paez, Tamara T. Haque, Amina Abdul Qayum, Marcela T. Taruselli, John J. Ryan
Publikováno v:
J Immunol
Sepsis has a well-studied inflammatory phase, with a less-understood secondary immunosuppressive phase. Elevated blood lactate and slow lactate clearance are associated with mortality; however, regulatory roles are unknown. We hypothesized that lacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f6db542e2770805bd8a57b6fd1aa73
https://doi.org/10.4049/jimmunol.1801005
https://doi.org/10.4049/jimmunol.1801005
Autor:
Kaitlyn Jackson, Rebecca K. Martin, E. Motunrayo Kolawole, Patrick A Paez, Jamie Josephine Avila McLeod, John J. Ryan, Matthew P. Zellner, Bianca Baker, Tamara T. Haque, Kasalina N. Kiwanuka, Anuya Paranjape, Jordan M. Dailey, Sydney A. Kee
Publikováno v:
Cell Immunol
Mast cells are found primarily at interfaces with the external environment, where they provide protection from pathogens but also elicit allergic inflammation. Mast cell activation by antigen-induced aggregation of IgE bound to the high affinity rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14f32184c1ca7aff5199053ec82e0fe
https://doi.org/10.1016/j.cellimm.2021.104344
https://doi.org/10.1016/j.cellimm.2021.104344
Autor:
John J. Ryan, E. Motunrayo Kolawole, Heather L. Caslin, David B. Straus, Patrick A Paez, Rebecca K. Martin, Brian O. Barnstein, Siddarth Ajith, Jamie Josephine Avila McLeod, Marcela T. Taruselli, Lawrence B. Schwartz, David A. Gewirtz, Quang T. Le, Yoshihiro Fukuoka, Kasalina N. Kiwanuka, Tamara T. Haque, Jordan M. Dailey, Sydney A. Kee
Publikováno v:
J Pharmacol Exp Ther
Statin drugs are widely employed in the clinic to reduce serum cholesterol. Because of their hydroxymethylglutaryl coenzyme A reductase antagonism, statins also reduce isoprenyl lipids necessary for the membrane anchorage and signaling of small G-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419e1893c555a9fbd145216ab640f613
https://pubmed.ncbi.nlm.nih.gov/32434944
https://pubmed.ncbi.nlm.nih.gov/32434944
Autor:
John R. Subjeck, Wenjie Liu, Patrick A Paez, Xiang-Yang Wang, Chunqing Guo, Xiaofei Yu, Harry D. Bear, Andrew Poklepovic, Chunyan Wei, Xueqian Cheng, Tuan-Wei Sun, Fang Yuan, Shixian Chen, Elizabeth A. Repasky, Joseph W. Landry
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
BackgroundThe efficacy of cancer immunotherapy can be limited by the poor immunogenicity of cancer and the immunosuppressive tumor microenvironment (TME). Immunologically programming the TME and creating an immune-inflamed tumor phenotype is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0abc591c1160a2dee261c4ec3b952e
https://doi.org/10.1136/jitc-2020-001595
https://doi.org/10.1136/jitc-2020-001595
Publikováno v:
The Journal of Immunology. 204:169.35-169.35
Radiation therapy (RT) is one of the primary treatment modalities for head and neck squamous cell carcinoma (HNSCC). At the time of diagnosis two-thirds of HNSCC patients have local-advanced disease and 50–60% of these patients will experience a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5abde0e8e94b2ee7dde3e4f10ec1372
https://doi.org/10.4049/jimmunol.204.supp.169.35
https://doi.org/10.4049/jimmunol.204.supp.169.35
The HMGCR Inhibitor Fluvastatin Induces Apoptosis and Autophagy in Primary and Neoplastic Mast Cells
Publikováno v:
The Journal of Immunology. 202:54.12-54.12
Mast cell hyperplasia is noted in many inflammatory and allergic diseases. Mast cells can also generate a subtype of acute myelogenous leukemia. Understanding and treating mast cell hyperplasia and leukemia could be beneficial to both inflammatory an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acd8dac67cbbb23adc70fb0438c63444
https://doi.org/10.4049/jimmunol.202.supp.54.12
https://doi.org/10.4049/jimmunol.202.supp.54.12
Autor:
Brian O. Barnstein, Kasalina N. Kiwanuka, Patrick A Paez, Heather L. Caslin, Victor S. Ndaw, Marcela T. Taruselli, Tamara T. Haque, Andrew J. Spence, Bianca Baker, Alena P. Chumanevich, John J. Ryan, E. Motunrayo Kolawole, Carole A. Oskeritzian, Daniel Abebayehu, Anuya Paranjape
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(3)
TGF-β1 is involved in many pathological conditions, including autoimmune disorders, cancer, and cardiovascular and allergic diseases. We have previously found that TGF-β1 can suppress IgE-mediated mast cell activation of human and mouse mast cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c360447f415c4744a8f7be3896bcfb
https://pubmed.ncbi.nlm.nih.gov/28637902
https://pubmed.ncbi.nlm.nih.gov/28637902
The HMGCR inhibitor Fluvastatin induces apoptosis and autophagy in primary and neoplastic mast cells
Publikováno v:
The Journal of Immunology. 198:67.22-67.22
Mast cells are best known for their role in inflammatory and allergic disease. Mast cell leukemia is a rare subtype of acute myelogenous leukemia, typically expressing the c-Kit mutation, D816V, that yields factor-independent growth. Understanding an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e46e37918050107bc824d2f7c366e1ab
https://doi.org/10.4049/jimmunol.198.supp.67.22
https://doi.org/10.4049/jimmunol.198.supp.67.22