Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Patrick A Lewis"'
Autor:
Yibo Zhao, Nikoleta Vavouraki, Ruth C Lovering, Valentina Escott-Price, Kirsten Harvey, Patrick A Lewis, Claudia Manzoni
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010847 (2023)
Mutations in LRRK2 are the most common genetic cause of Parkinson's disease. Despite substantial research efforts, the physiological and pathological role of this multidomain protein remains poorly defined. In this study, we used a systematic approac
Externí odkaz:
https://doaj.org/article/1f3c7c54bb334c4e8da94f2f1468b5ac
Publikováno v:
Neural Development, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background The starlet sea anemone, Nematostella vectensis, is an emerging model organism with a high regenerative capacity, which was recently found to possess an orthologue to the human Leucine Rich Repeat Kinase 2 (LRRK2) gene. Mutations
Externí odkaz:
https://doaj.org/article/2aae7aeabf8e41aab84c451d03d80df0
Autor:
Yibo Zhao, Matthew Bracher-Smith, Yuelin Li, Kirsten Harvey, Valentina Escott-Price, Patrick A. Lewis, Claudia Manzoni
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Mutations in the LRRK2 gene are the most common genetic cause of familial Parkinson’s Disease (LRRK2-PD) and an important risk factor for sporadic PD (sPD). Multiple clinical trials are ongoing to evaluate the benefits associated with the
Externí odkaz:
https://doaj.org/article/fc4590b86b70457288bcf07b9fac00ae
Autor:
Alastair J Noyce, Demis A Kia, Gibran Hemani, Aude Nicolas, T Ryan Price, Eduardo De Pablo-Fernandez, Philip C Haycock, Patrick A Lewis, Thomas Foltynie, George Davey Smith, International Parkinson Disease Genomics Consortium, Anette Schrag, Andrew J Lees, John Hardy, Andrew Singleton, Mike A Nalls, Neil Pearce, Debbie A Lawlor, Nicholas W Wood
Publikováno v:
PLoS Medicine, Vol 14, Iss 6, p e1002314 (2017)
BackgroundBoth positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual con
Externí odkaz:
https://doaj.org/article/3ae4a7e291f54933abfaf4b7d94b3e03
Autor:
Daniah Trabzuni, Mina Ryten, Warren Emmett, Adaikalavan Ramasamy, Karl J Lackner, Tanja Zeller, Robert Walker, Colin Smith, Patrick A Lewis, Adamantios Mamais, Rohan de Silva, Jana Vandrovcova, International Parkinson Disease Genomics Consortium (IPDGC), Dena Hernandez, Michael A Nalls, Manu Sharma, Sophie Garnier, Suzanne Lesage, Javier Simon-Sanchez, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew Singleton, Huaibin Cai, Eric Schadt, Nicholas W Wood, Rina Bandopadhyay, Michael E Weale, John Hardy, Vincent Plagnol
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70724 (2013)
Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy. However, little is known about the molecular mechanisms mediating these effects. To further characterize this locus
Externí odkaz:
https://doaj.org/article/aa919c6789b341e69f7b3a79a679c38a
Autor:
Selina Wray, Matthew Self, NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, NINDS ALS iPSC Consortium, Patrick A Lewis, Jan-Willem Taanman, Natalie S Ryan, Colin J Mahoney, Yuying Liang, Michael J Devine, Una-Marie Sheerin, Henry Houlden, Huw R Morris, Daniel Healy, Jose-Felix Marti-Masso, Elisavet Preza, Suzanne Barker, Margaret Sutherland, Roderick A Corriveau, Michael D'Andrea, Anthony H V Schapira, Ryan J Uitti, Mark Guttman, Grzegorz Opala, Barbara Jasinska-Myga, Andreas Puschmann, Christer Nilsson, Alberto J Espay, Jaroslaw Slawek, Ludwig Gutmann, Bradley F Boeve, Kevin Boylan, A Jon Stoessl, Owen A Ross, Nicholas J Maragakis, Jay Van Gerpen, Melissa Gerstenhaber, Katrina Gwinn, Ted M Dawson, Ole Isacson, Karen S Marder, Lorraine N Clark, Serge E Przedborski, Steven Finkbeiner, Jeffrey D Rothstein, Zbigniew K Wszolek, Martin N Rossor, John Hardy
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43099 (2012)
Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models
Externí odkaz:
https://doaj.org/article/9a35e1d7ec9b460c9b9c8d8637a681ec
Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
Autor:
Michael J Devine, Alice Kaganovich, Mina Ryten, Adamantios Mamais, Daniah Trabzuni, Claudia Manzoni, Philip McGoldrick, Diane Chan, Allissa Dillman, Julia Zerle, Susannah Horan, Jan-Willem Taanman, John Hardy, Jose-Felix Marti-Masso, Daniel Healy, Anthony H Schapira, Benjamin Wolozin, Rina Bandopadhyay, Mark R Cookson, Marcel P van der Brug, Patrick A Lewis
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22489 (2011)
Point mutations in LRRK2 cause autosomal dominant Parkinson's disease. Despite extensive efforts to determine the mechanism of cell death in patients with LRRK2 mutations, the aetiology of LRRK2 PD is not well understood. To examine possible alterati
Externí odkaz:
https://doaj.org/article/c6fe6ed743ea4ec3bf74262e0c03b0ea
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001257 (2010)
Cancer and neurodegeneration are often thought of as disease mechanisms at opposite ends of a spectrum; one due to enhanced resistance to cell death and the other due to premature cell death. There is now accumulating evidence to link these two dispa
Externí odkaz:
https://doaj.org/article/5970e6070f8149c0bf6f1f7170996c3d
Autor:
Selina Wray, Patrick A Lewis
Publikováno v:
Frontiers in Psychiatry, Vol 1 (2010)
Parkinson's disease (PD) represents a major challenge for health care systems around the world: it is the most common degenerative movement disorder of old age, affecting over 100,000 people in the UK alone. A great deal of progress has been made in
Externí odkaz:
https://doaj.org/article/f66eea8d2f6d48dd91cb11196ce6544e
Autor:
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Thomas Warner, John Hardy, Patrick A. Lewis, Jennifer Pocock, Mark R. Cookson, Rina Bandopadhyay
Publikováno v:
Cells, Vol 13, Iss 1, p 53 (2023)
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause autosomal dominant Parkinson’s disease (PD), with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain. LRRK2 protein is highly expressed in the human
Externí odkaz:
https://doaj.org/article/fd1712ee720f403b97f1792cb7f73082