Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Patrick A, Limbach"'
Autor:
Alice Baek, Asif Rayhan, Ga-Eun Lee, Sarah Golconda, Hannah Yu, Shihyoung Kim, Patrick A. Limbach, Balasubrahmanyam Addepalli, Sanggu Kim
Publikováno v:
Methods and Protocols, Vol 7, Iss 1, p 7 (2024)
The biological significance of chemical modifications to the ribonucleic acid (RNA) of human immunodeficiency virus type-1 (HIV-1) has been recognized. However, our understanding of the site-specific and context-dependent roles of these chemical modi
Externí odkaz:
https://doaj.org/article/fd6c948307bd4866a25be31f2d0f6180
Autor:
Luigi D’Ascenzo, Anna M. Popova, Scott Abernathy, Kai Sheng, Patrick A. Limbach, James R. Williamson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
RNA modifications represent a critical aspect of RNA biology that is not well suited to sequencing methods. Here, the authors provide a software tool for automated analysis of RNA tandem mass spectra with full support of modifications, isotope labell
Externí odkaz:
https://doaj.org/article/fb0d549380c444b89e9c3b49b50c66d3
Autor:
Cassandra Herbert, Corinna L. Ohrnberger, Ella Quinlisk, Balasubrahmanyam Addepalli, Patrick A. Limbach
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3270 (2023)
The activated forms of the environmental pollutant benzo[a]pyrene (B[a]P), such as benzo[a]pyrene diol epoxide (BPDE), are known to cause damage to genomic DNA and proteins. However, the impact of BPDE on ribonucleic acid (RNA) remains unclear. To un
Externí odkaz:
https://doaj.org/article/3d6a8abaae6b463da8c631c86e96ba96
Autor:
Melissa Kelley, Mellie June Paulines, George Yoshida, Ryan Myers, Manasses Jora, Joel P Levoy, Balasubrahmanyam Addepalli, Joshua B Benoit, Patrick A Limbach
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0266239 (2022)
Cryptococcus neoformans is a fungus that is able to survive abnormally high levels of ionizing radiation (IR). The radiolysis of water by IR generates reactive oxygen species (ROS) such as H2O2 and OH-. C. neoformans withstands the damage caused by I
Externí odkaz:
https://doaj.org/article/9ea9d25b973149ceb2753c0866bb043e
Autor:
Mariana Estevez, Satenik Valesyan, Manasses Jora, Patrick A. Limbach, Balasubrahmanyam Addepalli
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Oxidative stress triggered by the Fenton reaction (chemical) or UVR exposure (photo) can damage cellular biomolecules including RNA through oxidation of nucleotides. Besides such xenobiotic chemical modifications, RNA also contains several post-trans
Externí odkaz:
https://doaj.org/article/a625f2c913fa416e83cb272ebf1001fa
Autor:
Holly M Funk, Ruoxia Zhao, Maggie Thomas, Sarah M Spigelmyer, Nichlas J Sebree, Regan O Bales, Jamison B Burchett, Justen B Mamaril, Patrick A Limbach, Michael P Guy
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242737 (2020)
Posttranscriptional modification of tRNA is critical for efficient protein translation and proper cell growth, and defects in tRNA modifications are often associated with human disease. Although most of the enzymes required for eukaryotic tRNA modifi
Externí odkaz:
https://doaj.org/article/e7f239aef046469c8bc28f0291c60ace
Autor:
Evelyne Collignon, Brandon Cho, Julie Fothergill-Robinson, Giacomo Furlan, Robert L. Ross, Patrick A. Limbach, Miguel Ramalho-Santos
Embryos across metazoan lineages can enter reversible states of developmental pausing, or diapause, in response to adverse environmental conditions. The molecular mechanisms that underlie this remarkable dormant state remain largely unknown. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6584db34d496e35cd1b4d3f85092faa
https://doi.org/10.1101/2023.01.30.526234
https://doi.org/10.1101/2023.01.30.526234
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1527 (2020)
Ultraviolet radiation (UVR) adversely affects the integrity of DNA, RNA, and their nucleoside modifications. By employing liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based RNA modification mapping approaches, we identified the trans
Externí odkaz:
https://doaj.org/article/c9771a07181f418d9a18a9ed1ce7bd51
Autor:
Valérie de Crécy-Lagard, Robert L. Ross, Marshall Jaroch, Virginie Marchand, Christina Eisenhart, Damien Brégeon, Yuri Motorin, Patrick A. Limbach
Publikováno v:
Biomolecules, Vol 10, Iss 7, p 977 (2020)
Extensive knowledge of both the nature and position of tRNA modifications in all cellular tRNAs has been limited to two bacteria, Escherichia coli and Mycoplasma capricolum. Bacillus subtilis sp subtilis strain 168 is the model Gram-positive bacteria
Externí odkaz:
https://doaj.org/article/d190285a1b79450aa53e7a7369d0591f
Autor:
Sameer Dixit, Alan C Kessler, Jeremy Henderson, Xiaobei Pan, Ruoxia Zhao, Gabriel Silveira D’Almeida, Sneha Kulkarni, Mary Anne T Rubio, Eva Hegedűsová, Robert L Ross, Patrick A Limbach, Brian D Green, Zdeněk Paris, Juan D Alfonzo
Publikováno v:
Nucleic Acids Research
Dixit, S, Kessler, A C, Henderson, J, Pan, X, Zhao, R, D'Almeida, G S, Kulkarni, S, Rubio, M A T, Hegedűsová, E, Ross, R L, Limbach, P A, Green, B D, Paris, Z & Alfonzo, J D 2021, ' Dynamic queuosine changes in tRNA couple nutrient levels to codon choice in Trypanosoma brucei ', Nucleic Acids Research, vol. 49, no. 22, pp. 12986-12999 . https://doi.org/10.1093/nar/gkab1204
Dixit, S, Kessler, A C, Henderson, J, Pan, X, Zhao, R, D'Almeida, G S, Kulkarni, S, Rubio, M A T, Hegedűsová, E, Ross, R L, Limbach, P A, Green, B D, Paris, Z & Alfonzo, J D 2021, ' Dynamic queuosine changes in tRNA couple nutrient levels to codon choice in Trypanosoma brucei ', Nucleic Acids Research, vol. 49, no. 22, pp. 12986-12999 . https://doi.org/10.1093/nar/gkab1204
Every type of nucleic acid in cells undergoes programmed chemical post-transcriptional modification. Generally, modification enzymes use substrates derived from intracellular metabolism, one exception is queuine (q)/queuosine (Q), which eukaryotes ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2ee557655385c375eb4defff11dae6
https://doi.org/10.1093/nar/gkab1204
https://doi.org/10.1093/nar/gkab1204