Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Patrick S. Daugherty"'
Autor:
Winston A. Haynes, Kathy Kamath, Joel Bozekowski, Elisabeth Baum-Jones, Melissa Campbell, Arnau Casanovas-Massana, Patrick S. Daugherty, Charles S. Dela Cruz, Abhilash Dhal, Shelli F. Farhadian, Lynn Fitzgibbons, John Fournier, Michael Jhatro, Gregory Jordan, Jon Klein, Carolina Lucas, Debra Kessler, Larry L. Luchsinger, Brian Martinez, M. Catherine Muenker, Lauren Pischel, Jack Reifert, Jaymie R. Sawyer, Rebecca Waitz, Elsio A. Wunder, Minlu Zhang, Yale IMPACT Team, Akiko Iwasaki, Albert Ko, John C. Shon
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on
Externí odkaz:
https://doaj.org/article/35fd28046b3d4061a1a0e849a204b9bb
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.
Externí odkaz:
https://doaj.org/article/05d4a1f9278e456eb4e1635dc620ccf7
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer. Discovering antigens at a proteome scale could enable broader identification of antigens that
Externí odkaz:
https://doaj.org/article/4081611d5772442ebdf128e99c011aa0
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0217668 (2019)
Antibodies are essential to functional immunity, yet the epitopes targeted by antibody repertoires remain largely uncharacterized. To aid in characterization, we developed a generalizable strategy to predict antibody-binding epitopes within individua
Externí odkaz:
https://doaj.org/article/f8b283ddbd544faabcdf9b12823727e1
Autor:
Felix Y. Feng, John C. Shon, David Y. Oh, Antoni Ribas, Patrick S. Daugherty, Eric J. Small, Rahul Aggarwal, Alan Ashworth, Joshi J. Alumkal, Robert E. Reiter, Kim N. Chi, Primo Lara, Christopher P. Evans, Martin Gleave, Matthew Rettig, Tomasz M. Beer, Jonathan Chou, David A. Quigley, Martin Sjöström, Shuang G. Zhao, Meng Zhang, Ivan Perez Garcilazo, Ignacio Baselga Carretero, Adam Foye, Minlu Zhang, Raunak Shrestha, Agustin Vega-Crespo, Kathy Kamath, Rebecca Waitz, Winston A. Haynes, William S. Chen
Purpose:Autoantibody responses in cancer are of great interest, as they may be concordant with T-cell responses to cancer antigens or predictive of response to cancer immunotherapies. Thus, we sought to characterize the antibody landscape of metastat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af44d37d107e4ca4b490fcf564a77c3
https://doi.org/10.1158/1078-0432.c.6529490
https://doi.org/10.1158/1078-0432.c.6529490
Autor:
Felix Y. Feng, John C. Shon, David Y. Oh, Antoni Ribas, Patrick S. Daugherty, Eric J. Small, Rahul Aggarwal, Alan Ashworth, Joshi J. Alumkal, Robert E. Reiter, Kim N. Chi, Primo Lara, Christopher P. Evans, Martin Gleave, Matthew Rettig, Tomasz M. Beer, Jonathan Chou, David A. Quigley, Martin Sjöström, Shuang G. Zhao, Meng Zhang, Ivan Perez Garcilazo, Ignacio Baselga Carretero, Adam Foye, Minlu Zhang, Raunak Shrestha, Agustin Vega-Crespo, Kathy Kamath, Rebecca Waitz, Winston A. Haynes, William S. Chen
Supplementary Figures S1-S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be51ace537111ff881a675918f446c7
https://doi.org/10.1158/1078-0432.22476788
https://doi.org/10.1158/1078-0432.22476788
Supplementary Fig. from Cell surface profiling with peptide libraries yields ligand arrays that classify breast tumor subtypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261f498c8ef983d0f0dee2995e3205c5
https://doi.org/10.1158/1535-7163.22485243.v1
https://doi.org/10.1158/1535-7163.22485243.v1
Cancer heterogeneity renders risk stratification and therapy decisions challenging. Thus, genomic and proteomic methodologies have been used in an effort to identify biomarkers that can differentiate tumor subtypes to improve therapeutic outcome. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38169f272ea8d470610d20249d8279cf
https://doi.org/10.1158/1535-7163.c.6531846.v1
https://doi.org/10.1158/1535-7163.c.6531846.v1
Autor:
Felix Y. Feng, John C. Shon, David Y. Oh, Antoni Ribas, Patrick S. Daugherty, Eric J. Small, Rahul Aggarwal, Alan Ashworth, Joshi J. Alumkal, Robert E. Reiter, Kim N. Chi, Primo Lara, Christopher P. Evans, Martin Gleave, Matthew Rettig, Tomasz M. Beer, Jonathan Chou, David A. Quigley, Martin Sjöström, Shuang G. Zhao, Meng Zhang, Ivan Perez Garcilazo, Ignacio Baselga Carretero, Adam Foye, Minlu Zhang, Raunak Shrestha, Agustin Vega-Crespo, Kathy Kamath, Rebecca Waitz, Winston A. Haynes, William S. Chen
Supplementary Tables S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d5dad6df60e8b9205316c9a2e272c2
https://doi.org/10.1158/1078-0432.22476785.v1
https://doi.org/10.1158/1078-0432.22476785.v1
Autor:
Renna Luo, Chen Liu, Serra E. Elliott, Wei Wang, Nicholas Parchim, Takayuki Iriyama, Patrick S. Daugherty, Lijian Tao, Holger K. Eltzschig, Sean C. Blackwell, Baha M. Sibai, Rodney E. Kellems, Yang Xia
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 7 (2016)
BackgroundThe pathogenesis of essential hypertension is multifactorial with different underlying mechanisms contributing to disease. We have recently shown that TNF superfamily member 14 LIGHT (an acronym for homologous to lymphotoxins, exhibits indu
Externí odkaz:
https://doaj.org/article/436b89b47b0749558aa503f708260934